PMID- 28624699
OWN - NLM
STAT- MEDLINE
DCOM- 20180620
LR  - 20180620
IS  - 1879-1506 (Electronic)
IS  - 0003-9969 (Linking)
VI  - 82
DP  - 2017 Oct
TI  - Toll-like receptor 2 rs4696480 polymorphism and risk of oral cancer and oral 
      potentially malignant disorder.
PG  - 109-114
LID - S0003-9969(17)30180-2 [pii]
LID - 10.1016/j.archoralbio.2017.06.003 [doi]
AB  - OBJECTIVES: The aim of this study was to identify the possible association 
      between TLR polymorphisms and an increased risk of developing head and neck 
      cancer, including oral (OSCC) and laryngeal squamous cell carcinoma (LSCC), and 
      oral potentially malignant disorders, such as oral lichenoid disease (OLD), 
      including oral lichen planus (OLP) and oral lichenoid lesions (OLL). DESIGN: This 
      case-control study included 40 OSCC, 35 LSCC, 175 OLD (129 OLP and 46 OLL) 
      patients and 89 healthy controls, all of them from the Basque Country, Spain. 
      Genetic polymorphisms in TLR1, TLR2, TLR4, TLR6, TLR9, and TLR10 were genotyped 
      by TaqMan((R)) assays or pyrosequencing. RESULTS: The chi-square analysis showed 
      that the variant A of the SNP TLR2-rs4696480 polymorphism significantly increased 
      the risk of OSCC (p=0.03) and OLL (p=0.02). CONCLUSIONS: The TLR2-rs4696480 
      polymorphism may be relevant to OSCC and OLL susceptibility in this population 
      encouraging further studies on the TLR2 pathway and its possible association with 
      this group of oral potentially malignant disorders and oral cancer. This may also 
      prove the use of TLR polymorphisms as risk markers for oral and laryngeal cancer.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - de Barros Gallo, Camila
AU  - de Barros Gallo C
AD  - Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Marichalar-Mendia, Xabier
AU  - Marichalar-Mendia X
AD  - Oral Medicine & Pathology, Department of Stomatology II, UFI 11/25, University of 
      the Basque Country (UPV/EHU), Leioa, Spain. Electronic address: 
      xabier.marichalar@gmail.com.
FAU - Setien-Olarra, Amaia
AU  - Setien-Olarra A
AD  - Oral Medicine & Pathology, Department of Stomatology II, UFI 11/25, University of 
      the Basque Country (UPV/EHU), Leioa, Spain.
FAU - Acha-Sagredo, Amelia
AU  - Acha-Sagredo A
AD  - Oral Medicine & Pathology, Department of Stomatology II, UFI 11/25, University of 
      the Basque Country (UPV/EHU), Leioa, Spain.
FAU - Bediaga, Naiara Garcia
AU  - Bediaga NG
AD  - Oral Medicine & Pathology, Department of Stomatology II, UFI 11/25, University of 
      the Basque Country (UPV/EHU), Leioa, Spain.
FAU - Gainza-Cirauqui, Maria Luisa
AU  - Gainza-Cirauqui ML
AD  - Department of Dental Surgery, Faculty of Dental Surgery, University of Malta, 
      Malta.
FAU - Sugaya, Norberto Nobuo
AU  - Sugaya NN
AD  - Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Aguirre-Urizar, Jose Manuel
AU  - Aguirre-Urizar JM
AD  - Oral Medicine & Pathology, Department of Stomatology II, UFI 11/25, University of 
      the Basque Country (UPV/EHU), Leioa, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170606
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
RN  - 0 (Toll-Like Receptor 2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - Lichen Planus, Oral/*genetics
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Precancerous Conditions/*genetics
MH  - Risk
MH  - Spain
MH  - Toll-Like Receptor 2/*genetics
OTO - NOTNLM
OT  - Oral cancer
OT  - Oral lichen planus
OT  - Precancerous conditions
OT  - Single nucleotide polymorphisms
OT  - Toll-like receptors
EDAT- 2017/06/19 06:00
MHDA- 2018/06/21 06:00
CRDT- 2017/06/19 06:00
PHST- 2016/12/15 00:00 [received]
PHST- 2017/06/02 00:00 [revised]
PHST- 2017/06/03 00:00 [accepted]
PHST- 2017/06/19 06:00 [pubmed]
PHST- 2018/06/21 06:00 [medline]
PHST- 2017/06/19 06:00 [entrez]
AID - S0003-9969(17)30180-2 [pii]
AID - 10.1016/j.archoralbio.2017.06.003 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2017 Oct;82:109-114. doi: 10.1016/j.archoralbio.2017.06.003. Epub 
      2017 Jun 6.