PMID- 28625175
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20170724
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 117
IP  - 10
DP  - 2017 May
TI  - May the Mediterranean diet attenuate the risk of type 2 diabetes associated with 
      obesity: the Seguimiento Universidad de Navarra (SUN) cohort.
PG  - 1478-1485
LID - 10.1017/S0007114517001404 [doi]
AB  - It is likely that the Mediterranean diet (MedDiet) may mitigate the adverse 
      effects of obesity on the incidence of type 2 diabetes mellitus (T2DM). We 
      assessed this hypothesis in a cohort of 18 225 participants initially free of 
      diabetes (mean age: 38 years, 61 % women). A validated semi-quantitative 136-item 
      FFQ was used to assess dietary intake and to build a 0-9 score of adherence to 
      MedDiet. After a median of 9.5-year follow-up, 136 incident cases of T2DM were 
      confirmed during 173 591 person-years follow-up. When MedDiet adherence was low 
      (</=4 points), the multivariable-adjusted hazard ratios (HR) were 4.07 (95 % CI 
      1.58, 10.50) for participants with BMI 25-29.99 kg/m2 and 17.70 (95 % CI 6.29, 
      49.78) kg/m2 for participants with BMI>/=30 kg/m2, (v.4 points), these 
      multivariable-adjusted HR were 3.13 (95 % CI 1.63, 6.01) and 10.70 (95 % CI 4.98, 
      22.99) for BMI 25-30 and >/=30 kg/m2, respectively. The P value for the interaction 
      was statistically significant (P=0.002). When we assessed both variables (BMI and 
      MedDiet) as continuous, the P value for their interaction product-term was 
      marginally significant (P=0.051) in fully adjusted models. This effect 
      modification was not explained by weight changes during follow-up. Our results 
      suggest that the MedDiet may attenuate the adverse effects of obesity on the risk 
      of T2DM.
FAU - Eguaras, Sonia
AU  - Eguaras S
AD  - 1Department of Preventive Medicine and Public Health,Institute of Investigation 
      of Navarra (IdiSNA),University of Navarra,Irunlarrea 1,31008 Pamplona,Spain.
FAU - Bes-Rastrollo, Maira
AU  - Bes-Rastrollo M
AD  - 1Department of Preventive Medicine and Public Health,Institute of Investigation 
      of Navarra (IdiSNA),University of Navarra,Irunlarrea 1,31008 Pamplona,Spain.
FAU - Ruiz-Canela, Miguel
AU  - Ruiz-Canela M
AD  - 1Department of Preventive Medicine and Public Health,Institute of Investigation 
      of Navarra (IdiSNA),University of Navarra,Irunlarrea 1,31008 Pamplona,Spain.
FAU - Carlos, Silvia
AU  - Carlos S
AD  - 1Department of Preventive Medicine and Public Health,Institute of Investigation 
      of Navarra (IdiSNA),University of Navarra,Irunlarrea 1,31008 Pamplona,Spain.
FAU - de la Rosa, Pedro
AU  - de la Rosa P
AD  - 1Department of Preventive Medicine and Public Health,Institute of Investigation 
      of Navarra (IdiSNA),University of Navarra,Irunlarrea 1,31008 Pamplona,Spain.
FAU - Martinez-Gonzalez, Miguel A
AU  - Martinez-Gonzalez MA
AD  - 1Department of Preventive Medicine and Public Health,Institute of Investigation 
      of Navarra (IdiSNA),University of Navarra,Irunlarrea 1,31008 Pamplona,Spain.
LA  - eng
PT  - Journal Article
DEP - 20170619
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
SB  - IM
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*etiology
MH  - *Diet, Mediterranean
MH  - Female
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - Obesity/*complications/*diet therapy
MH  - Risk Factors
OTO - NOTNLM
OT  - HR hazard ratio
OT  - MedDiet Mediterranean diet
OT  - PREDIMED Prevencion con dieta Mediterranea
OT  - T2DM type 2 diabetes mellitus
OT  - BMI
OT  - Cohorts
OT  - Diabetes
OT  - Mediterranean diet
OT  - Obesity
EDAT- 2017/06/20 06:00
MHDA- 2017/07/25 06:00
CRDT- 2017/06/20 06:00
PHST- 2017/06/20 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2017/06/20 06:00 [entrez]
AID - S0007114517001404 [pii]
AID - 10.1017/S0007114517001404 [doi]
PST - ppublish
SO  - Br J Nutr. 2017 May;117(10):1478-1485. doi: 10.1017/S0007114517001404. Epub 2017 
      Jun 19.