PMID- 28625674
OWN - NLM
STAT- MEDLINE
DCOM- 20180821
LR  - 20180821
IS  - 1872-7484 (Electronic)
IS  - 1566-0702 (Linking)
VI  - 207
DP  - 2017 Nov
TI  - Regional cerebral cortical thickness correlates with autonomic outflow.
PG  - 28-36
LID - S1566-0702(17)30137-6 [pii]
LID - 10.1016/j.autneu.2017.05.012 [doi]
AB  - Dysregulation of autonomic control often develops with advancing age, favoring a 
      chronic state of heightened sympathetic outflow with parasympathetic withdrawal. 
      However, the mechanisms of this age-related autonomic impairment are not known. 
      This study tested the hypothesis that inter-individual differences in autonomic 
      outflow across the adult age-span are related to cerebral cortex thickness. A 
      total of 55 healthy, active individuals participated in this study (21-73years; 
      18 female). Physical fitness was treated as a possible covariate (VO(2peak): 
      26-81mL/kg/min). Cardiovagal baroreflex sensitivity, heart rate variability, and 
      muscle sympathetic nerve activity (MSNA) were assessed during a laboratory 
      session. T1-weighted images acquired at 3T facilitated measures of cortical 
      thickness (Brain Voyager 2.8.4). A priori cortical regions of interest included 
      the medial prefrontal cortex (MPFC) and insula cortex. Cortical thickness at the 
      MPFC correlated strongly with markers of autonomic outflow including heart rate 
      variability (ln-high frequency power (slope: -16, r(2)=0.65), SDNN (slope: 22, 
      r(2)=0.22), total power (slope: 2872, r(2)=0.24)), and MSNA variables (burst 
      frequency (slope: 1, r(2)=0.16), burst incidence (slope: -26, r(2)=0.62) and 
      total MSNA (slope: -847, r(2)=0.56)). Further associations with burst incidence 
      were observed within the left insula (p<0.05). Importantly, the strength of the 
      relationship between autonomic variables and cortical thickness was determined by 
      age, and was not altered following adjustments for cardiorespiratory fitness. The 
      current results implicate cortical atrophy in the frontal lobe as a contributor 
      to both the sympathetic and parasympathetic changes that occur with age.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Wood, Katelyn N
AU  - Wood KN
AD  - Neurovascular Research Laboratory, School of Kinesiology, Western University, 
      London, Ontario N6A 3K7, Canada.
FAU - Badrov, Mark B
AU  - Badrov MB
AD  - Neurovascular Research Laboratory, School of Kinesiology, Western University, 
      London, Ontario N6A 3K7, Canada.
FAU - Speechley, Mark R
AU  - Speechley MR
AD  - Department of Epidemiology and Biostatistics, Western University, London, Ontario 
      N6A 3K7, Canada.
FAU - Shoemaker, J Kevin
AU  - Shoemaker JK
AD  - Neurovascular Research Laboratory, School of Kinesiology, Western University, 
      London, Ontario N6A 3K7, Canada; Department of Physiology and Pharmacology, 
      Western University, London, Ontario N6A 3K7, Canada. Electronic address: 
      kshoemak@uwo.ca.
LA  - eng
PT  - Journal Article
DEP - 20170607
PL  - Netherlands
TA  - Auton Neurosci
JT  - Autonomic neuroscience : basic & clinical
JID - 100909359
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Autonomic Nervous System/*physiology
MH  - Baroreflex/*physiology
MH  - Blood Pressure/physiology
MH  - Cerebral Cortex/*physiology
MH  - Female
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/physiology
MH  - Sympathetic Nervous System/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Autonomic control
OT  - Cortical thickness
OT  - Insula
OT  - Medial prefrontal cortex
EDAT- 2017/06/20 06:00
MHDA- 2018/08/22 06:00
CRDT- 2017/06/20 06:00
PHST- 2017/01/08 00:00 [received]
PHST- 2017/04/06 00:00 [revised]
PHST- 2017/05/31 00:00 [accepted]
PHST- 2017/06/20 06:00 [pubmed]
PHST- 2018/08/22 06:00 [medline]
PHST- 2017/06/20 06:00 [entrez]
AID - S1566-0702(17)30137-6 [pii]
AID - 10.1016/j.autneu.2017.05.012 [doi]
PST - ppublish
SO  - Auton Neurosci. 2017 Nov;207:28-36. doi: 10.1016/j.autneu.2017.05.012. Epub 2017 
      Jun 7.