PMID- 28626770
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20221207
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2017
DP  - 2017
TI  - Upregulation of Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 mRNA Is 
      Negatively Correlated with Serum Concentrations of Tumor Necrosis Factor-alpha and 
      Interleukin 6 in Type 2 Diabetes Mellitus.
PG  - 4802319
LID - 10.1155/2017/4802319 [doi]
LID - 4802319
AB  - BACKGROUND: Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) 
      is a negative regulator of natural and adaptive immunity. The role of TIPE2 in 
      type 2 diabetes mellitus (T2DM) remains unknown, although TIPE2 plays key roles 
      in preserving inflammatory homeostasis. METHODS: TIPE2 expression was measured by 
      Western blotting and real-time polymerase chain reaction (RT-PCR) in peripheral 
      blood mononuclear cells (PBMCs) isolated from T2DM patients and healthy controls, 
      and tumor necrosis factor-alpha (TNF-alpha), high-sensitivity C-reactive protein (hsCRP), 
      interleukin 6 (IL-6), and other related biometabolic parameters were detected 
      using a nephelometer or by ELISA. Differentiated THP-1 cells were exposed to 
      siTIPE2 and TIPE2 adenovirus. RESULTS: TIPE2 was significantly increased in PBMCs 
      from T2DM patients compared with those from healthy controls and was negatively 
      correlated with serum TNF-alpha, IL-6, and hsCRP concentrations but positively 
      correlated with HbA1c and LDL-C in T2DM patients. High glucose treatment 
      (50 mmol/L) can upregulate the expression of TIPE2 and cytokine secretion in 
      differentiated THP-1 cells. siTIPE2 infection exacerbated the increased TNF-alpha and 
      IL-6 concentrations in differentiated THP-1 cells under high glucose conditions 
      (50 mmol/L), while infection with TIPE2 adenovirus reversed the increased TNF-alpha 
      concentration. CONCLUSIONS: The present study indicates that TIPE2 may 
      participate in T2DM by regulating TNF-alpha production.
FAU - Liu, Yongliang
AU  - Liu Y
AD  - Central of Translation Medicine, Zibo Central Hospital Affiliated to Shandong 
      University, Zibo 255036, China.
FAU - Wang, Xinmei
AU  - Wang X
AD  - Department of Pathology, Zibo Central Hospital Affiliated to Shandong University, 
      Zibo 255036, China.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - Department of Central Laboratory, Zibo Central Hospital Affiliated to Shandong 
      University, Zibo 255036, China.
FAU - Zhao, Peiqing
AU  - Zhao P
AD  - Central of Translation Medicine, Zibo Central Hospital Affiliated to Shandong 
      University, Zibo 255036, China.
FAU - Wang, Lianqing
AU  - Wang L
AD  - Central of Translation Medicine, Zibo Central Hospital Affiliated to Shandong 
      University, Zibo 255036, China.
FAU - Zhai, Qiaoli
AU  - Zhai Q
AD  - Central of Translation Medicine, Zibo Central Hospital Affiliated to Shandong 
      University, Zibo 255036, China.
FAU - Zhang, Xiaowei
AU  - Zhang X
AD  - Central of Translation Medicine, Zibo Central Hospital Affiliated to Shandong 
      University, Zibo 255036, China.
FAU - Tian, Wenxiu
AU  - Tian W
AD  - Central of Translation Medicine, Zibo Central Hospital Affiliated to Shandong 
      University, Zibo 255036, China.
FAU - Xiang, Xinxin
AU  - Xiang X
AUID- ORCID: 0000-0002-4476-3160
AD  - Central of Translation Medicine, Zibo Central Hospital Affiliated to Shandong 
      University, Zibo 255036, China.
FAU - Li, Tao
AU  - Li T
AUID- ORCID: 0000-0002-6427-0830
AD  - Central of Translation Medicine, Zibo Central Hospital Affiliated to Shandong 
      University, Zibo 255036, China.
LA  - eng
PT  - Journal Article
DEP - 20170524
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (TNFAIP8L2 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adaptive Immunity
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Cholesterol, LDL/metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - Glucose/analysis
MH  - Glycated Hemoglobin/analysis
MH  - Homeostasis
MH  - Humans
MH  - Inflammation
MH  - Interleukin-6/*blood
MH  - Intracellular Signaling Peptides and Proteins/*metabolism
MH  - Leukocytes, Mononuclear/cytology
MH  - Male
MH  - Middle Aged
MH  - RNA, Messenger/metabolism
MH  - RNA, Small Interfering/metabolism
MH  - Tumor Necrosis Factor-alpha/*blood
PMC - PMC5463106
EDAT- 2017/06/20 06:00
MHDA- 2018/04/24 06:00
PMCR- 2017/05/24
CRDT- 2017/06/20 06:00
PHST- 2016/12/02 00:00 [received]
PHST- 2017/03/04 00:00 [revised]
PHST- 2017/04/04 00:00 [accepted]
PHST- 2017/06/20 06:00 [entrez]
PHST- 2017/06/20 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/05/24 00:00 [pmc-release]
AID - 10.1155/2017/4802319 [doi]
PST - ppublish
SO  - J Diabetes Res. 2017;2017:4802319. doi: 10.1155/2017/4802319. Epub 2017 May 24.