PMID- 28626871
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1386-6346 (Print)
IS  - 1386-6346 (Linking)
VI  - 48
IP  - 3
DP  - 2018 Feb
TI  - Successful living donor liver retransplantation for graft failure within 7 days 
      due to acute de novo donor-specific anti-human leukocyte antigen 
      antibody-mediated rejection.
PG  - E360-E366
LID - 10.1111/hepr.12924 [doi]
AB  - Growing evidence suggests a relationship between antibody-mediated rejection 
      (AMR) and early graft failure due to a previously unknown etiology in liver 
      transplantation (LTx). We herein report a 3-year-old boy who developed rapid 
      graft failure due to de novo donor-specific antibody (DSA)-driven AMR a week 
      after living donor LTx, requiring a second transplant on the 10th day after the 
      first LTx. The pathology of the first graft showed massive necrosis in zone 3 
      along with positive C4d and inflammatory cell infiltrates in portal areas. The 
      mean fluorescence intensity against human leukocyte antigen (HLA)-DR15, which was 
      possessed by both the first and the second donor, peaked at 12 945 on the day 
      before the second LTx. Antithymocyte globulin, plasma exchange along with i.v. 
      immunoglobulin, rituximab, and the local infusion of prostaglandin E1, steroids, 
      and Mesilate gabexate through a portal catheter were provided to save the second 
      graft. To our knowledge, this is the first report to show a clear association 
      between de novo DSA and acute AMR within 7 days of a LTx. Furthermore, we 
      successfully rescued the recipient with a second graft despite possessing the 
      same targeted HLA. The rapid decision to carry out retransplantation and specific 
      strategies overcoming AMR were crucial to achieving success in this case of 
      immunologically high-risk LTx.
CI  - (c) 2017 The Japan Society of Hepatology.
FAU - Yamada, Yohei
AU  - Yamada Y
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Hoshino, Ken
AU  - Hoshino K
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Mori, Teisaburo
AU  - Mori T
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Kawaida, Miho
AU  - Kawaida M
AD  - Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
FAU - Abe, Kiyotomo
AU  - Abe K
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Ishihama, Hideo
AU  - Ishihama H
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Shimizu, Takahiro
AU  - Shimizu T
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Takahashi, Nobuhiro
AU  - Takahashi N
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Matsubara, Kentaro
AU  - Matsubara K
AD  - Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
FAU - Hibi, Taizo
AU  - Hibi T
AD  - Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
FAU - Abe, Yuta
AU  - Abe Y
AD  - Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
FAU - Yagi, Hiroshi
AU  - Yagi H
AD  - Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
FAU - Shimojima, Naoki
AU  - Shimojima N
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Shinoda, Masahiro
AU  - Shinoda M
AD  - Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
FAU - Kitago, Minoru
AU  - Kitago M
AD  - Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
FAU - Obara, Hideaki
AU  - Obara H
AD  - Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
FAU - Fuchimoto, Yasushi
AU  - Fuchimoto Y
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
FAU - Kameyama, Kaori
AU  - Kameyama K
AD  - Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
FAU - Kitagawa, Yuko
AU  - Kitagawa Y
AD  - Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
FAU - Kuroda, Tatsuo
AU  - Kuroda T
AD  - Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, 
      Japan.
LA  - eng
PT  - Case Reports
DEP - 20170816
PL  - Netherlands
TA  - Hepatol Res
JT  - Hepatology research : the official journal of the Japan Society of Hepatology
JID - 9711801
OTO - NOTNLM
OT  - desensitization
OT  - donor-specific antibody
OT  - liver transplantation
OT  - retransplantation
OT  - seventh day syndrome
EDAT- 2017/06/20 06:00
MHDA- 2017/06/20 06:01
CRDT- 2017/06/20 06:00
PHST- 2017/04/24 00:00 [received]
PHST- 2017/05/23 00:00 [revised]
PHST- 2017/06/15 00:00 [accepted]
PHST- 2017/06/20 06:00 [pubmed]
PHST- 2017/06/20 06:01 [medline]
PHST- 2017/06/20 06:00 [entrez]
AID - 10.1111/hepr.12924 [doi]
PST - ppublish
SO  - Hepatol Res. 2018 Feb;48(3):E360-E366. doi: 10.1111/hepr.12924. Epub 2017 Aug 16.