PMID- 28629533
OWN - NLM
STAT- MEDLINE
DCOM- 20180426
LR  - 20220321
IS  - 1875-5364 (Electronic)
IS  - 1875-5364 (Linking)
VI  - 15
IP  - 6
DP  - 2017 Jun
TI  - Design of new traditional Chinese medicine herbal formulae for treatment of type 
      2 diabetes mellitus based on network pharmacology.
PG  - 436-441
LID - S1875-5364(17)30065-1 [pii]
LID - 10.1016/S1875-5364(17)30065-1 [doi]
AB  - In the present study, 28 Chinese medicinal herbs belonging to traditional Chinese 
      medicine (TCM) for the treatment of type 2 diabetes were selected to explore the 
      application of network pharmacology in developing new Chinese herbal medicine 
      formulae for the treatment of type 2 diabetes mellitus (T2DM). These herbs have 
      the highest appearance rate in the literature, and their compounds are listed. 
      The human protein-protein interaction network and the T2DM disease protein 
      interaction network were constructed. Then, the related algorithm for network 
      topology was used to perform interventions on the interaction network of disease 
      proteins and normal human proteins to test different Chinese herbal medicine 
      compound combinations, according to the information on the interaction of 
      compounds-targets in two databases, namely TarNet and the Medicinal Plants 
      Database. Results of the intervention scores indicate that the method proposed in 
      this study can provide new effective combinations of Chinese herbal medicines for 
      T2DM. Network pharmacology can effectively promote the modernization and 
      development of TCM.
CI  - Copyright (c) 2017 China Pharmaceutical University. Published by Elsevier B.V. All 
      rights reserved.
FAU - Hu, Rui-Feng
AU  - Hu RF
AD  - Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese 
      Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal 
      Plant Development, Peking Union Medical College and Chinese Academy of Medical 
      Sciences, Beijing 100193, China; Key Laboratory of Bioactive Substances and 
      Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 
      100193, China; Zhongguancun Open Laboratory of the Research and Development of 
      Natural Medicine and Health Products, Beijing 100193, China.
FAU - Sun, Xiao-Bo
AU  - Sun XB
AD  - Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese 
      Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal 
      Plant Development, Peking Union Medical College and Chinese Academy of Medical 
      Sciences, Beijing 100193, China; Key Laboratory of Bioactive Substances and 
      Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 
      100193, China; Zhongguancun Open Laboratory of the Research and Development of 
      Natural Medicine and Health Products, Beijing 100193, China. Electronic address: 
      sun_xiaobo163@163.com.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin J Nat Med
JT  - Chinese journal of natural medicines
JID - 101504416
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Drug Design
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Humans
MH  - *Medicine, Chinese Traditional
MH  - Protein Interaction Maps
OTO - NOTNLM
OT  - Network pharmacology
OT  - Nework intervention
OT  - Protein-protein interaction network
OT  - TCM formulae
OT  - Type 2 diabetes mellitus
EDAT- 2017/06/21 06:00
MHDA- 2018/04/27 06:00
CRDT- 2017/06/21 06:00
PHST- 2016/11/21 00:00 [received]
PHST- 2017/06/21 06:00 [entrez]
PHST- 2017/06/21 06:00 [pubmed]
PHST- 2018/04/27 06:00 [medline]
AID - S1875-5364(17)30065-1 [pii]
AID - 10.1016/S1875-5364(17)30065-1 [doi]
PST - ppublish
SO  - Chin J Nat Med. 2017 Jun;15(6):436-441. doi: 10.1016/S1875-5364(17)30065-1.