PMID- 28630408
OWN - NLM
STAT- MEDLINE
DCOM- 20181219
LR  - 20181219
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jun 19
TI  - The cellular and circuit basis for evolutionary change in sensory perception in 
      mormyrid fishes.
PG  - 3783
LID - 10.1038/s41598-017-03951-y [doi]
LID - 3783
AB  - Species differences in perception have been linked to divergence in gross 
      neuroanatomical features of sensory pathways. The anatomical and physiological 
      basis of evolutionary change in sensory processing at cellular and circuit 
      levels, however, is poorly understood. Here, we show how specific changes to a 
      sensory microcircuit are associated with the evolution of a novel perceptual 
      ability. In mormyrid fishes, the ability to detect variation in electric 
      communication signals is correlated with an enlargement of the midbrain 
      exterolateral nucleus (EL), and a differentiation into separate anterior (ELa) 
      and posterior (ELp) regions. We show that the same cell types and connectivity 
      are found in both EL and ELa/ELp. The evolution of ELa/ELp, and the concomitant 
      ability to detect signal variation, is associated with a lengthening of incoming 
      hindbrain axons to form delay lines, allowing for fine temporal analysis of 
      signals. The enlargement of this brain region is also likely due to an overall 
      increase in cell numbers, which would allow for processing of a wider range of 
      timing information.
FAU - Velez, Alejandro
AU  - Velez A
AD  - Department of Biology, Washington University in St. Louis, St. Louis, MO, USA.
FAU - Kohashi, Tsunehiko
AU  - Kohashi T
AD  - Department of Biology, Washington University in St. Louis, St. Louis, MO, USA.
AD  - Division of Biological Science, Graduate School of Science, Nagoya University, 
      Nagoya, Japan.
FAU - Lu, Anan
AU  - Lu A
AD  - Department of Biology, Washington University in St. Louis, St. Louis, MO, USA.
FAU - Carlson, Bruce A
AU  - Carlson BA
AD  - Department of Biology, Washington University in St. Louis, St. Louis, MO, USA. 
      carlson.bruce@wustl.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170619
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Animals
MH  - *Biological Evolution
MH  - Fishes/anatomy & histology/*physiology
MH  - Mesencephalon/anatomy & histology/*physiology
MH  - Sensation/*physiology
PMC - PMC5476679
COIS- The authors declare that they have no competing interests.
EDAT- 2017/06/21 06:00
MHDA- 2018/12/20 06:00
PMCR- 2017/06/19
CRDT- 2017/06/21 06:00
PHST- 2017/02/17 00:00 [received]
PHST- 2017/05/10 00:00 [accepted]
PHST- 2017/06/21 06:00 [entrez]
PHST- 2017/06/21 06:00 [pubmed]
PHST- 2018/12/20 06:00 [medline]
PHST- 2017/06/19 00:00 [pmc-release]
AID - 10.1038/s41598-017-03951-y [pii]
AID - 3951 [pii]
AID - 10.1038/s41598-017-03951-y [doi]
PST - epublish
SO  - Sci Rep. 2017 Jun 19;7(1):3783. doi: 10.1038/s41598-017-03951-y.