PMID- 28631844
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20181206
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 96
IP  - 1
DP  - 2018 Jan
TI  - Sonic hedgehog, Wnt, and brain-derived neurotrophic factor cell signaling pathway 
      crosstalk: potential therapy for depression.
PG  - 53-62
LID - 10.1002/jnr.24104 [doi]
AB  - There are various theories to explain the pathophysiology of depression and 
      support its diagnosis and treatment. The roles of monoamines, brain-derived 
      neurotrophic factor (BDNF), and Wnt signaling are well researched, but sonic 
      hedgehog (Shh) signaling and its downstream transcription factor Gli1 are not 
      well studied in depression. Shh signaling plays a fundamental role in embryonic 
      development and adult hippocampal neurogenesis and also involved in the growth of 
      cancer. In this article, we summarize the evidence for the Shh signaling pathway 
      in depression and the potential crosstalk of Shh with Wnt and BDNF. 
      Antidepressants are known to upregulate the adult hippocampal neurogenesis to 
      treat depression. Shh plays an important role in adult hippocampal neurogenesis, 
      and its downstream signaling components regulate the synthesis of Wnt proteins. 
      Moreover, the expression of Gli1 and Smo is downregulated in depression. BDNF and 
      Wnt signaling are also regulated by various available antidepressants, so there 
      is the possibility that Shh may be involved in the pathophysiology of depression. 
      Therefore, the crosstalk between the Shh, Wnt, and BDNF signaling pathways is 
      being discussed to identify the potential targets. Specifically, the potential 
      role of the Shh signaling pathway in depression is explored as a new target for 
      better therapies for depression.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Tayyab, Mohd
AU  - Tayyab M
AD  - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim 
      University, Aligarh, India.
FAU - Shahi, Mehdi H
AU  - Shahi MH
AUID- ORCID: 0000-0001-9589-4382
AD  - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim 
      University, Aligarh, India.
FAU - Farheen, Shirin
AU  - Farheen S
AD  - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim 
      University, Aligarh, India.
FAU - Mariyath, Mubeena P M
AU  - Mariyath MPM
AD  - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim 
      University, Aligarh, India.
FAU - Khanam, Nabeela
AU  - Khanam N
AD  - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim 
      University, Aligarh, India.
FAU - Castresana, Javier S
AU  - Castresana JS
AD  - Department of Biochemistry and Genetics, University of Navarra, Faculty of 
      Sciences, Pamplona, Spain.
FAU - Hossain, M Mobarak
AU  - Hossain MM
AD  - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim 
      University, Aligarh, India.
AD  - Department of Physiology, JNMC, Faculty of Medicine, Aligarh Muslim University, 
      Aligarh, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170620
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Antidepressive Agents)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (SHH protein, human)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage/*metabolism
MH  - Depression/*drug therapy/*metabolism
MH  - Drug Delivery Systems/trends
MH  - Hedgehog Proteins/*metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Humans
MH  - Neurogenesis/drug effects/physiology
MH  - Receptor Cross-Talk/drug effects/physiology
MH  - Signal Transduction/drug effects/physiology
MH  - Wnt Signaling Pathway/drug effects/*physiology
OTO - NOTNLM
OT  - BDNF
OT  - Wnt
OT  - depression
OT  - neurogenesis
OT  - sonic hedgehog
EDAT- 2017/06/21 06:00
MHDA- 2018/06/23 06:00
CRDT- 2017/06/21 06:00
PHST- 2017/04/06 00:00 [received]
PHST- 2017/05/16 00:00 [revised]
PHST- 2017/05/22 00:00 [accepted]
PHST- 2017/06/21 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
PHST- 2017/06/21 06:00 [entrez]
AID - 10.1002/jnr.24104 [doi]
PST - ppublish
SO  - J Neurosci Res. 2018 Jan;96(1):53-62. doi: 10.1002/jnr.24104. Epub 2017 Jun 20.