PMID- 28632031
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20180430
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 42
IP  - 7
DP  - 2017 Jul
TI  - MR Imaging of the Anterior Visual Pathway in Primary Open-Angle Glaucoma: 
      Correlation with Octopus 101 Perimetry and Spectralis Optical Coherence 
      Tomography Findings.
PG  - 995-1001
LID - 10.1080/02713683.2017.1279633 [doi]
AB  - PURPOSE: To investigate structural changes in the visual pathway measured by 
      magnetic resonance imaging (MRI) and its relationship with the clinical severity 
      of glaucoma in primary open-angle glaucoma (POAG) patients. MATERIALS AND 
      METHODS: The study included 28 patients with POAG and 26 age- and sex-matched 
      healthy volunteers. All the subjects underwent spectral domain optical coherence 
      tomography (OCT) of the peripapillary retina nerve fiber layer (RNFL). The optic 
      nerve diameter (OND), chiasma height (Ch), and lateral geniculate nucleus height 
      (LGNh) were measured bilaterally using a 1.5-Tesla MRI system. RESULTS: The mean 
      values of the OND and LGNh were significantly lower in the POAG group (OND: right 
      p = 0.043 and left p = 0.048; LGNh: right p = 0.008 and left p = 0.025). The OND 
      was not correlated with the clinical stage of glaucoma, but it was correlated 
      with the ipsilateral RNFL thickness. The Ch was correlated with the ipsilateral 
      clinical stage (right r = -0.536, p = 0.004; left r = -0.537, p = 0.004) and 
      average RNFL thickness (RNFLav) (right r = 0.655, p < 0.001; left r = 0.626, p < 
      0.001). The sum of bilateral clinical stages and left clinical stages showed 
      significant correlations with the right and left LGNh and the sum of both the 
      right and left LGNh. The left RNFLav and the sum of the right-left RNFLav were 
      significantly correlated with all LGNh measurements. CONCLUSIONS: 1.5-Tesla MRI 
      can detect structural changes in the visual pathway early in the course of 
      glaucoma. Thin optic nerve can be a risk factor for glaucoma. The Ch and LGNh 
      seem to be correlated with the clinical stage of glaucoma and RNFL thickness. In 
      particular, LGN can be a target of glaucomatous damage.
FAU - Ersoz, Mehmet Giray
AU  - Ersoz MG
AD  - a Department of Ophthalmology , Kiziltepe Government Hospital , Mardin , Turkey.
FAU - Pekcevik, Yeliz
AU  - Pekcevik Y
AD  - b Department of Radiology , Tepecik Education and Research Hospital , Izmir , 
      Turkey.
FAU - Ayintap, Emre
AU  - Ayintap E
AD  - c Department of Ophthalmology , Tepecik Education and Research Hospital , Izmir , 
      Turkey.
FAU - Gunes, Irfan Botan
AU  - Gunes IB
AD  - d Department of Ophthalmology , Borcka Government Hospital , Artvin , Turkey.
FAU - Mart, Duygu Kunak
AU  - Mart DK
AD  - c Department of Ophthalmology , Tepecik Education and Research Hospital , Izmir , 
      Turkey.
FAU - Yucel, Ersin
AU  - Yucel E
AD  - c Department of Ophthalmology , Tepecik Education and Research Hospital , Izmir , 
      Turkey.
FAU - Ture, Gamze
AU  - Ture G
AD  - c Department of Ophthalmology , Tepecik Education and Research Hospital , Izmir , 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170228
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
SB  - IM
MH  - Adult
MH  - Aged
MH  - Equipment Design
MH  - Female
MH  - Follow-Up Studies
MH  - Geniculate Bodies/pathology
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Healthy Volunteers
MH  - Humans
MH  - Intraocular Pressure/*physiology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Chiasm/pathology
MH  - Optic Nerve/pathology
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*pathology
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Field Tests/*instrumentation
MH  - Visual Pathways/*pathology
OTO - NOTNLM
OT  - Glaucomatous optic nerve damage
OT  - lateral geniculate nucleus
OT  - magnetic resonance imaging
OT  - octopus perimetry
OT  - optic chiasm
OT  - retinal nerve fiber layer thickness
EDAT- 2017/06/21 06:00
MHDA- 2018/01/18 06:00
CRDT- 2017/06/21 06:00
PHST- 2017/06/21 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2017/06/21 06:00 [entrez]
AID - 10.1080/02713683.2017.1279633 [doi]
PST - ppublish
SO  - Curr Eye Res. 2017 Jul;42(7):995-1001. doi: 10.1080/02713683.2017.1279633. Epub 
      2017 Feb 28.