PMID- 28632203
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20231213
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 7
IP  - 6
DP  - 2017 Jun 20
TI  - Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker 
      for Alzheimer's disease.
PG  - e1154
LID - 10.1038/tp.2017.123 [doi]
AB  - Early identification of Alzheimer's disease (AD) risk factors would aid 
      development of interventions to delay the onset of dementia, but current 
      biomarkers are invasive and/or costly to assess. Validated plasma biomarkers 
      would circumvent these challenges. We previously identified the kinase DYRK1A in 
      plasma. To validate DYRK1A as a biomarker for AD diagnosis, we assessed the 
      levels of DYRK1A and the related markers brain-derived neurotrophic factor (BDNF) 
      and homocysteine in two unrelated AD patient cohorts with age-matched controls. 
      Receiver-operating characteristic curves and logistic regression analyses showed 
      that combined assessment of DYRK1A, BDNF and homocysteine has a sensitivity of 
      0.952, a specificity of 0.889 and an accuracy of 0.933 in testing for AD. The 
      blood levels of these markers provide a diagnosis assessment profile. Combined 
      assessment of these three markers outperforms most of the previous markers and 
      could become a useful substitute to the current panel of AD biomarkers. These 
      results associate a decreased level of DYRK1A with AD and challenge the use of 
      DYRK1A inhibitors in peripheral tissues as treatment. These measures will be 
      useful for diagnosis purposes.
FAU - Janel, N
AU  - Janel N
AD  - Universite Paris Diderot, Sorbonne Paris Cite, Unite de Biologie Fonctionnelle et 
      Adaptative, Paris, France.
FAU - Alexopoulos, P
AU  - Alexopoulos P
AD  - Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische 
      Universitat Munchen, Munich, Germany.
AD  - Department of Psychiatry, University Hospital of Rion, University of Patras, 
      Patras, Greece.
FAU - Badel, A
AU  - Badel A
AD  - Universite Paris Diderot, Sorbonne Paris Cite, Paris, France.
FAU - Lamari, F
AU  - Lamari F
AD  - Department of Metabolic Biochemistry, Groupe Hospitalier Pitie 
      Salpetriere-Charles Foix, Paris, France.
FAU - Camproux, A C
AU  - Camproux AC
AD  - Universite Paris Diderot, Sorbonne Paris Cite, Paris, France.
FAU - Lagarde, J
AU  - Lagarde J
AD  - Unit of Neurology of Memory and Langage, Universite Paris Descartes, Sorbonne 
      Paris Cite, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France.
FAU - Simon, S
AU  - Simon S
AD  - CEA, DSV, iBiTec-S, Laboratoire d'etudes et de recherches en immunoanalyse, 
      Gif-sur-Yvette, France.
FAU - Feraudet-Tarisse, C
AU  - Feraudet-Tarisse C
AD  - CEA, DSV, iBiTec-S, Laboratoire d'etudes et de recherches en immunoanalyse, 
      Gif-sur-Yvette, France.
FAU - Lamourette, P
AU  - Lamourette P
AD  - CEA, DSV, iBiTec-S, Laboratoire d'etudes et de recherches en immunoanalyse, 
      Gif-sur-Yvette, France.
FAU - Arbones, M
AU  - Arbones M
AD  - Instituto de Biologia Molecular de Barcelona (CSIC), Barcelona, Spain.
FAU - Paul, J L
AU  - Paul JL
AD  - AP-HP, Hopital Europeen Georges Pompidou, Service de Biochimie, Paris, France.
FAU - Dubois, B
AU  - Dubois B
AD  - Alzheimer Institute (MB, LCdS, BD, MS), Department of Neurology, Hopital 
      Pitie-Salpetriere (Assistance Publique-Hopitaux de Paris), Paris, France.
FAU - Potier, M C
AU  - Potier MC
AD  - INSERM U1127, CNRS UMR 7225, Sorbonne Universites, UPMC Univ Paris 06 UMRS 1127, 
      Institut du Cerveau et de la Moelle epiniere, ICM, Paris, France.
FAU - Sarazin, M
AU  - Sarazin M
AD  - Unit of Neurology of Memory and Langage, Universite Paris Descartes, Sorbonne 
      Paris Cite, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France.
FAU - Delabar, J M
AU  - Delabar JM
AD  - INSERM U1127, CNRS UMR 7225, Sorbonne Universites, UPMC Univ Paris 06 UMRS 1127, 
      Institut du Cerveau et de la Moelle epiniere, ICM, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20170620
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*blood/diagnosis/immunology
MH  - Animals
MH  - Antibodies, Monoclonal/metabolism/pharmacology
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Middle Aged
MH  - Protein Serine-Threonine Kinases/*blood/immunology
MH  - Protein-Tyrosine Kinases/*blood/immunology
MH  - ROC Curve
MH  - Dyrk Kinases
PMC - PMC5537644
COIS- The authors declare no conflict of interest.
EDAT- 2017/06/21 06:00
MHDA- 2018/03/27 06:00
PMCR- 2017/06/01
CRDT- 2017/06/21 06:00
PHST- 2016/12/23 00:00 [received]
PHST- 2017/04/27 00:00 [revised]
PHST- 2017/04/28 00:00 [accepted]
PHST- 2017/06/21 06:00 [entrez]
PHST- 2017/06/21 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - tp2017123 [pii]
AID - 10.1038/tp.2017.123 [doi]
PST - epublish
SO  - Transl Psychiatry. 2017 Jun 20;7(6):e1154. doi: 10.1038/tp.2017.123.