PMID- 28634644
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20191210
IS  - 1573-6709 (Electronic)
IS  - 0033-2720 (Linking)
VI  - 89
IP  - 1
DP  - 2018 Mar
TI  - Minimal Clinically Important Differences (MCID) in Assessing Outcomes of 
      Post-Traumatic Stress Disorder.
PG  - 141-155
LID - 10.1007/s11126-017-9522-y [doi]
AB  - This study sought to determine the minimal clinically important difference (MCID) 
      for two frequently used measures of symptom severity in Post-Traumatic Stress 
      Disorder: the Clinician Administered PTSD Scale (CAPS) and the PTSD Symptom 
      Checklist (PCL). Data from a randomized clinical trial of antipsychotic 
      medication in military-related treatment-resistant PTSD (N= 267) included 
      assessments 4 times over 26 weeks. Methods for estimating the MCID were based on 
      both the anchor-based approach, using the Clinical Global Impressions (CGI) 
      severity and improvement scales, rated by both clinicians and patients; and the 
      distribution-based approach (based on standardized z-scores). Severity and change 
      scores on the CAPS and PCL were converted to z-scores and compared across CGI 
      levels using analysis of variance. The average difference in CAPS z-scores 
      between each of three CGI levels between "moderate" to "severe" and from "no 
      change" to "much improved" was 0.758 for clinician CGI ratings and 0.525 for 
      patient CGI ratings and were similar for the PCL (0.483 and 0.471) with all 
      differences significant at p<.0001). Clinically meaningful CAPS and PCL severity 
      and change z-scores range between 0.5-0.8 standard deviations. The MCID estimates 
      suggested here provide an empirical basis for determining whether statistically 
      significant changes in CAPS and PCL scores are clinically meaningful.
FAU - Stefanovics, Elina A
AU  - Stefanovics EA
AD  - VA New England Mental Illness Research and Education Center, VA Connecticut 
      Healthcare System (116A-4), 950 Campbell Avenue, Building 36, West Haven, CT, 
      06516, USA. elina.stefanovics@yale.edu.
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. 
      elina.stefanovics@yale.edu.
FAU - Rosenheck, Robert A
AU  - Rosenheck RA
AD  - VA New England Mental Illness Research and Education Center, VA Connecticut 
      Healthcare System (116A-4), 950 Campbell Avenue, Building 36, West Haven, CT, 
      06516, USA.
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
FAU - Jones, Karen M
AU  - Jones KM
AD  - VA Cooperative Studies Coordinating Center, Point, Perry, MD, USA.
FAU - Huang, Grant
AU  - Huang G
AD  - VA Cooperative Studies Program Central Office, Washington, D.C, USA.
FAU - Krystal, John H
AU  - Krystal JH
AD  - VA New England Mental Illness Research and Education Center, VA Connecticut 
      Healthcare System (116A-4), 950 Campbell Avenue, Building 36, West Haven, CT, 
      06516, USA.
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
AD  - Clinical Neuroscience Division, Department of Veterans Affairs National Center 
      for PTSD, West Haven, CT, USA.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Psychiatr Q
JT  - The Psychiatric quarterly
JID - 0376465
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*pharmacology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Outcome Assessment, Health Care/methods/*standards
MH  - Psychiatric Status Rating Scales/*standards
MH  - Stress Disorders, Post-Traumatic/*drug therapy/*physiopathology
MH  - United States
MH  - United States Department of Veterans Affairs
MH  - *Veterans
OTO - NOTNLM
OT  - Minimal clinically important difference
OT  - Outcome assessment
OT  - PTSD
EDAT- 2017/06/22 06:00
MHDA- 2018/11/06 06:00
CRDT- 2017/06/22 06:00
PHST- 2017/06/22 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2017/06/22 06:00 [entrez]
AID - 10.1007/s11126-017-9522-y [pii]
AID - 10.1007/s11126-017-9522-y [doi]
PST - ppublish
SO  - Psychiatr Q. 2018 Mar;89(1):141-155. doi: 10.1007/s11126-017-9522-y.