PMID- 28637174
OWN - NLM
STAT- MEDLINE
DCOM- 20190725
LR  - 20190725
IS  - 1469-994X (Electronic)
IS  - 1462-2203 (Print)
IS  - 1462-2203 (Linking)
VI  - 20
IP  - 4
DP  - 2018 Mar 6
TI  - Effect of Prenatal Exposure to Waterpipe Tobacco Smoke on Learning and Memory of 
      Adult Offspring Rats.
PG  - 508-514
LID - 10.1093/ntr/ntx142 [doi]
AB  - INTRODUCTION: Waterpipe tobacco smoking has increased in prevalence worldwide, 
      including among pregnant women. In this study, we investigated the effect of 
      prenatal maternal waterpipe tobacco smoke (WTS) exposure during different stages 
      of pregnancy on learning and memory of adult offspring rats. METHODS: Pregnant 
      rats received either fresh air or mainstream WTS (2 hours daily) during early, 
      mid, late, or whole gestational period. Male offspring rats were followed through 
      20 weeks. Outcomes included (1) spatial learning and memory using the radial arm 
      water maze (RAWM), (2) levels of brain derived neurotrophic factor (BDNF) in the 
      hippocampus, and (3) oxidative stress biomarkers (superoxide dismutase, catalase, 
      glutathione peroxidase and thiobarbituric acid reactive substances). RESULTS: 
      Relative to offspring whose mothers were exposed to fresh air, prenatal exposure 
      to WTS at any stage of pregnancy resulted in short- and long-term memory 
      impairment in adult offspring rats (p < .05). This impairment was associated with 
      reduced levels of BDNF in hippocampus (p < .05). However, prenatal WTS did not 
      affect the level of oxidative stress biomarkers in hippocampus. Prenatal WTS 
      during late gestation increased the activity of catalase as compared to control. 
      CONCLUSION: Prenatal maternal WTS exposure can impair the memory of adult male 
      offspring. These results support development of interventions that target 
      pregnant women who smoke waterpipe during pregnancy. IMPLICATIONS: We examined 
      for the first time the effect of prenatal waterpipe tobacco smoke exposure on 
      learning and memory of offspring. The results showed that in utero exposure to 
      waterpipe tobacco smoke was associated with impaired memory and decreased brain 
      derived neurotrophic factor in hippocampus of adult male offspring rats.
FAU - Al-Sawalha, Nour
AU  - Al-Sawalha N
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Alzoubi, Karem
AU  - Alzoubi K
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Khabour, Omar
AU  - Khabour O
AD  - Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, 
      Jordan University of Science and Technology, Irbid, Jordan.
AD  - Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia.
FAU - Alyacoub, Weam
AU  - Alyacoub W
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Almahmmod, Yehya
AU  - Almahmmod Y
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Eissenberg, Thomas
AU  - Eissenberg T
AD  - Department of Psychology (Health Program) and Center for the Study of Tobacco 
      Products, Virginia Commonwealth University, Richmond, VA.
LA  - eng
GR  - P50 DA036105/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nicotine Tob Res
JT  - Nicotine & tobacco research : official journal of the Society for Research on 
      Nicotine and Tobacco
JID - 9815751
RN  - 0 (Biomarkers)
RN  - 0 (Smoke)
MH  - Age Factors
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Memory/*drug effects/physiology
MH  - Oxidative Stress/drug effects/physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/metabolism/*psychology
MH  - Rats
MH  - Rats, Wistar
MH  - Smoke/adverse effects
MH  - Tobacco Smoking/*adverse effects/metabolism
MH  - Tobacco, Waterpipe/*adverse effects
PMC - PMC5896430
EDAT- 2017/06/24 06:00
MHDA- 2019/07/26 06:00
PMCR- 2019/03/06
CRDT- 2017/06/23 06:00
PHST- 2017/02/28 00:00 [received]
PHST- 2017/06/16 00:00 [accepted]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2019/07/26 06:00 [medline]
PHST- 2017/06/23 06:00 [entrez]
PHST- 2019/03/06 00:00 [pmc-release]
AID - 3872331 [pii]
AID - ntx142 [pii]
AID - 10.1093/ntr/ntx142 [doi]
PST - ppublish
SO  - Nicotine Tob Res. 2018 Mar 6;20(4):508-514. doi: 10.1093/ntr/ntx142.