PMID- 28637229
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1460-2709 (Electronic)
IS  - 1369-3786 (Linking)
VI  - 56
IP  - 3
DP  - 2018 Apr 1
TI  - Can passage in Galleria mellonella activate virulence factors of Paracoccidioides 
      brasiliensis as in the murine model?
PG  - 374-377
LID - 10.1093/mmy/myx045 [doi]
AB  - Paracoccidioidomycosis (PCM) is a fungal disease restricted to Latin countries, 
      and its etiologic agents derive from the Paracoccidioides genus. Attenuation or 
      loss of virulence in Paracoccidioides spp. following successive subculturing has 
      been described. However, virulence can be recovered by passage in mammalian host. 
      In this study, the recovery of adhesion of P. brasiliensis through passage in 
      mice was compared to that in the insect Galleria mellonella. Analysis of in vitro 
      fungal-host cell interaction, gene expression of adhesins, and analysis of the 
      survival curves revealed that Galleria mellonella is useful for the reactivation 
      of P. brasiliensis adhesion.
FAU - Scorzoni, Liliana
AU  - Scorzoni L
AD  - Laboratorio de Micologia Clinica, Departamento de Analises Clinicas, Universidade 
      Estadual Paulista (UNESP), Faculdade de Ciencias Farmaceuticas, Araraquara, 
      Brasil.
FAU - de Paula E Silva, Ana Carolina Alves
AU  - de Paula E Silva ACA
AD  - Laboratorio de Micologia Clinica, Departamento de Analises Clinicas, Universidade 
      Estadual Paulista (UNESP), Faculdade de Ciencias Farmaceuticas, Araraquara, 
      Brasil.
FAU - de Oliveira, Haroldo Cesar
AU  - de Oliveira HC
AD  - Laboratorio de Micologia Clinica, Departamento de Analises Clinicas, Universidade 
      Estadual Paulista (UNESP), Faculdade de Ciencias Farmaceuticas, Araraquara, 
      Brasil.
FAU - Marcos, Caroline Maria
AU  - Marcos CM
AD  - Laboratorio de Micologia Clinica, Departamento de Analises Clinicas, Universidade 
      Estadual Paulista (UNESP), Faculdade de Ciencias Farmaceuticas, Araraquara, 
      Brasil.
FAU - Singulani, Junya de Lacorte
AU  - Singulani JL
AD  - Laboratorio de Micologia Clinica, Departamento de Analises Clinicas, Universidade 
      Estadual Paulista (UNESP), Faculdade de Ciencias Farmaceuticas, Araraquara, 
      Brasil.
FAU - Fusco-Almeida, Ana Marisa
AU  - Fusco-Almeida AM
AD  - Laboratorio de Micologia Clinica, Departamento de Analises Clinicas, Universidade 
      Estadual Paulista (UNESP), Faculdade de Ciencias Farmaceuticas, Araraquara, 
      Brasil.
FAU - Mendes-Giannini, Maria Jose Soares
AU  - Mendes-Giannini MJS
AD  - Laboratorio de Micologia Clinica, Departamento de Analises Clinicas, Universidade 
      Estadual Paulista (UNESP), Faculdade de Ciencias Farmaceuticas, Araraquara, 
      Brasil.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (Adhesins, Bacterial)
RN  - 0 (Virulence Factors)
SB  - IM
MH  - Adhesins, Bacterial/genetics/*metabolism
MH  - Animals
MH  - Disease Models, Animal
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Moths/*microbiology
MH  - Paracoccidioides/genetics/*pathogenicity
MH  - Paracoccidioidomycosis/*microbiology/*mortality/pathology
MH  - Survival Rate
MH  - Virulence/genetics
MH  - Virulence Factors/genetics/*metabolism
EDAT- 2017/06/24 06:00
MHDA- 2019/05/21 06:00
CRDT- 2017/06/23 06:00
PHST- 2017/01/12 00:00 [received]
PHST- 2017/05/29 00:00 [accepted]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2017/06/23 06:00 [entrez]
AID - 3868370 [pii]
AID - 10.1093/mmy/myx045 [doi]
PST - ppublish
SO  - Med Mycol. 2018 Apr 1;56(3):374-377. doi: 10.1093/mmy/myx045.