PMID- 28637362
OWN - NLM
STAT- MEDLINE
DCOM- 20180627
LR  - 20201209
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 25
IP  - 8
DP  - 2017 Dec
TI  - Spindle Cell Mucoepidermoid Carcinoma of the Palatine Tonsil With CRTC1-MAML2 
      Fusion Transcript: Report of a Rare Case in a 17-Year-Old Boy and a Review of the 
      Literature.
PG  - 705-710
LID - 10.1177/1066896917714890 [doi]
AB  - Mucoepidermoid carcinoma (MEC) with a predominant spindle cell composition 
      occurring in the palatine tonsil is exceedingly rare. We present a case of a 
      17-year-old boy with an uncommon spindle cell variant of MEC arising in the 
      palatine tonsil. Histologically, the tumor showed a solid, noncystic architecture 
      and was composed of a predominant population of bland spindle to fusiform cells 
      arranged in organoid nests with interspersed goblet cells and focal areas of 
      ductular structures. Reverse transcriptase polymerase chain reaction and 
      fluorescence in situ hybridization (FISH) revealed the presence of a t(11;19) 
      CRTC1-MAML2 gene fusion in this rare variant of MEC. This is the first case 
      report of a spindle cell MEC of the palatine tonsil, with molecular genetic 
      confirmation. It illustrates the importance of awareness and recognition of this 
      uncommon histological variant of MEC, which will help establish appropriate 
      treatment and prognostication.
FAU - Goh, Giap Hean
AU  - Goh GH
AD  - 1 National University Health System, Singapore.
FAU - Lim, Chwee Ming
AU  - Lim CM
AD  - 1 National University Health System, Singapore.
FAU - Vanacek, Tomas
AU  - Vanacek T
AD  - 2 Bioptical Laboratory, Pilsen, Czech Republic.
FAU - Michal, Michal
AU  - Michal M
AD  - 2 Bioptical Laboratory, Pilsen, Czech Republic.
FAU - Petersson, Fredrik
AU  - Petersson F
AD  - 1 National University Health System, Singapore.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20170621
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (CRTC1 protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MAML2 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adolescent
MH  - Carcinoma, Mucoepidermoid/*genetics/*pathology
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - Male
MH  - Nuclear Proteins/*genetics
MH  - Oncogene Proteins, Fusion/genetics
MH  - Palatine Tonsil/pathology
MH  - Tonsillar Neoplasms/*genetics/*pathology
MH  - Trans-Activators
MH  - Transcription Factors/*genetics
OTO - NOTNLM
OT  - CRTC1-MAML2
OT  - mucoepidermoid carcinoma
OT  - palatine tonsil
OT  - salivary gland carcinoma
OT  - spindle cell
EDAT- 2017/06/24 06:00
MHDA- 2018/06/28 06:00
CRDT- 2017/06/23 06:00
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2018/06/28 06:00 [medline]
PHST- 2017/06/23 06:00 [entrez]
AID - 10.1177/1066896917714890 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2017 Dec;25(8):705-710. doi: 10.1177/1066896917714890. Epub 
      2017 Jun 21.