PMID- 28637989
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20180502
IS  - 1880-4926 (Electronic)
IS  - 1343-4934 (Linking)
VI  - 59
IP  - 2
DP  - 2017
TI  - HLA-A*26-A*30 and HLA-DRB1*10 could be predictors of nasopharyngeal carcinoma 
      risk in high-risk Tunisian families.
PG  - 289-296
LID - 10.2334/josnusd.16-0646 [doi]
AB  - We investigated human leukocyte antigen (HLA) profiles for Tunisians with 
      nasopharyngeal carcinoma (NPC), their families, and a sample of unrelated healthy 
      Tunisians in order to identify HLA specificities associated with familial NPC. 
      HLA-A, -B, and -DRB1 typing was successful for 36 NPC patients, 72 unaffected 
      family members, and 130 community controls, and the chi square or Fisher exact 
      test was used to compare allele frequencies between cases and controls. We 
      observed a consistent protective effect of HLA-DRB1*10 on NPC development. 
      However, none of the NPC patients or their family members had a positive result 
      for this HLA marker (0% vs 9.2% in controls, P = 0.047). In addition, HLA-A*26 
      was probably an induction marker, as its allelic frequency was significantly 
      higher among NPC patients than among controls (P = 0.003) and among NPC patients 
      than among at-risk family members (P = 0.067). Logistic regression analysis of 
      the joint effect of selected HLA specificities showed that HLA-A*26 and HLA-A*30 
      were co-associated and have an important effect on NPC risk. Despite the small 
      size of our cohort, we showed that HLA-A*26-A*30 and HLA-DRB1*10 might be 
      predictive markers for NPC screening of Tunisian families with a high risk of 
      NPC.
FAU - Mokni-Baizig, Nehla
AU  - Mokni-Baizig N
AD  - Laboratory of Immunohistocytology, Salah Azaiz Cancer Institute.
FAU - Gorgi, Yosr
AU  - Gorgi Y
AD  - Laboratory of Immunology, Charles Nicolle Hospital.
FAU - Elghourabi, Mohamed
AU  - Elghourabi M
AD  - Department of Economic and Quantitative Methods, High School of Economic and 
      Commercial Sciences of Tunis.
FAU - Makhlouf, Mouna
AU  - Makhlouf M
AD  - Laboratory of Immunology, Charles Nicolle Hospital.
FAU - Boussen, Hamouda
AU  - Boussen H
AD  - Laboratory of Immunohistocytology, Salah Azaiz Cancer Institute.
FAU - Gritli, Said
AU  - Gritli S
AD  - Department of Otorhinolaryngology, Salah Azaiz Cancer Institute.
FAU - Elmay, Michele
AU  - Elmay M
AD  - Research Unit 01/UR/08-07, Faculty of Medicine, University of Tunis El Manar.
FAU - Gamoudi, Amor
AU  - Gamoudi A
AD  - Laboratory of Immunohistocytology, Salah Azaiz Cancer Institute.
FAU - Elmay, Ahmed
AU  - Elmay A
AD  - Laboratory of Immunohistocytology, Salah Azaiz Cancer Institute.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Oral Sci
JT  - Journal of oral science
JID - 9808942
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Disease Susceptibility/*immunology
MH  - Gene Frequency
MH  - HLA-A Antigens/genetics/*immunology
MH  - HLA-DRB1 Chains/genetics/*immunology
MH  - Humans
MH  - Nasopharyngeal Neoplasms/*immunology
MH  - Tunisia
OTO - NOTNLM
OT  - HLA typing
OT  - Tunisia
OT  - high-risk families
OT  - nasopharyngeal carcinoma
EDAT- 2017/06/24 06:00
MHDA- 2018/05/03 06:00
CRDT- 2017/06/23 06:00
PHST- 2017/06/23 06:00 [entrez]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
AID - 10.2334/josnusd.16-0646 [doi]
PST - ppublish
SO  - J Oral Sci. 2017;59(2):289-296. doi: 10.2334/josnusd.16-0646.