PMID- 28638109
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jun 21
TI  - Voxel-based morphometric brain comparison between healthy subjects and major 
      depressive disorder patients in Japanese with the s/s genotype of 5-HTTLPR.
PG  - 3931
LID - 10.1038/s41598-017-04347-8 [doi]
LID - 3931
AB  - Individuals with s/s genotype of serotonin transporter gene-linked promotor 
      region (5-HTTLPR), which appear with a high frequency in Japanese, exhibit more 
      diagnosable depression in relation to stressful life events than those with the 
      s/l or l/l genotype. We prospectively investigated the brain volume changes in 
      first-episode and medication naive major depression disorder patients (MDD) with 
      the s/s genotype in Japanese. We assessed the differences between 27 MDD with the 
      s/s genotype and 44 healthy subjects (HS) with the same genotype using a 
      whole-brain voxel-by-voxel statistical analysis of MRI. Gray matter volume in a 
      brain region with significant clusters obtained via voxel-based morphometry 
      analysis were measured and, as an exploratory analysis, evaluated for 
      relationships to the subcategory scores (core, sleep, activity, psychic, somatic 
      anxiety, delusion) of the Hamilton Depression Rating Scale (HAM-D) and the Social 
      Readjustment Rating Scale (SRRS). The brain volume in the left insula lobe was 
      significantly smaller in the MDD than in the HS. The left insula lobe volume 
      correlated negatively with the "psychic" score of HAM-D and the SRRS. In a 
      Japanese population with the s/s genotype, we found an atrophy of the insula in 
      the MDD, which might be associated with "psychic" symptom and stress events.
FAU - Igata, Natsuki
AU  - Igata N
AD  - Department of Radiology, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Kakeda, Shingo
AU  - Kakeda S
AD  - Department of Radiology, University of Occupational and Environmental Health, 
      Kitakyushu, Japan. kakeda@med.uoeh-u.ac.jp.
FAU - Watanabe, Keita
AU  - Watanabe K
AD  - Department of Radiology, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Ide, Satoru
AU  - Ide S
AD  - Department of Radiology, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Kishi, Taro
AU  - Kishi T
AD  - Department of Psychiatry, Fujita Health University, School of Medicine, Toyoake, 
      Japan.
FAU - Abe, Osamu
AU  - Abe O
AD  - Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, 
      Japan.
FAU - Igata, Ryouhei
AU  - Igata R
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Katsuki, Asuka
AU  - Katsuki A
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Iwata, Nakao
AU  - Iwata N
AD  - Department of Psychiatry, Fujita Health University, School of Medicine, Toyoake, 
      Japan.
FAU - Yoshimura, Reiji
AU  - Yoshimura R
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Korogi, Yukunori
AU  - Korogi Y
AD  - Department of Radiology, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170621
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Adult
MH  - Asian People/genetics
MH  - Brain/diagnostic imaging/*pathology
MH  - Depressive Disorder, Major/diagnostic imaging/*genetics/*pathology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
PMC - PMC5479858
COIS- The authors declare that they have no competing interests.
EDAT- 2017/06/24 06:00
MHDA- 2019/01/10 06:00
PMCR- 2017/06/21
CRDT- 2017/06/23 06:00
PHST- 2017/01/26 00:00 [received]
PHST- 2017/05/12 00:00 [accepted]
PHST- 2017/06/23 06:00 [entrez]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2017/06/21 00:00 [pmc-release]
AID - 10.1038/s41598-017-04347-8 [pii]
AID - 4347 [pii]
AID - 10.1038/s41598-017-04347-8 [doi]
PST - epublish
SO  - Sci Rep. 2017 Jun 21;7(1):3931. doi: 10.1038/s41598-017-04347-8.