PMID- 28638270
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20181113
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 14
IP  - 6
DP  - 2017
TI  - Existence of a Strong Correlation of Biomarkers and miRNA in Females with 
      Metabolic Syndrome and Obesity in a Population of West Virginia.
PG  - 543-553
LID - 10.7150/ijms.18988 [doi]
AB  - Objectives: Metabolic syndrome causes complications like cardiovascular disease 
      and type 2 diabetes mellitus (T2DM). As metabolic syndrome develops, altered 
      levels of cytokines and microRNAs (miRNA) are measurable in the circulation. We 
      aimed to construct a panel detecting abnormal levels of cytokines and miRNAs in 
      patients at risk for metabolic syndrome. Methods: Participants included 54 
      patients from a Family Medicine Clinic at Marshall University School of Medicine, 
      in groups of: Control, Obese, and Metabolic Syndrome (MetS). Results: Serum 
      levels of leptin, adiponectin, leptin: adiponectin ratio, IL-6, six miRNAs (320a, 
      197-3p, 23-3p, 221-3p, 27a-3p, and 130a-3p), were measured. Among the three 
      groups, leptin, and leptin: adiponectin ratio, and IL-6 levels were highest in 
      MetS, and levels in Obese were greater than Control (p>0.05). Adiponectin levels 
      were lower in Obese compared to Control, but lowest in MetS (p<0.05). MiRNAs 
      levels were lowest in MetS, and levels in Obese were lower than Control (p>0.05). 
      Conclusion: Our results support the clinical application of biomarkers in 
      diagnosing early stage MetS, which will enable attenuation of disease progression 
      before onset of irreversible complications. Since West Virginians are high-risk 
      for developing MetS, our biomarker panel could reduce the disease burden on our 
      population.
FAU - Goguet-Rubio, Perrine
AU  - Goguet-Rubio P
AD  - Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall 
      University, Huntington, WV, USA.
FAU - Klug, Rebecca L
AU  - Klug RL
AD  - Department of Surgery, Joan C. Edwards School of Medicine, Marshall University, 
      Huntington, WV, USA.
FAU - Sharma, Dana L
AU  - Sharma DL
AD  - Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall 
      University, Huntington, WV, USA.
FAU - Srikanthan, Krithika
AU  - Srikanthan K
AD  - Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall 
      University, Huntington, WV, USA.
FAU - Puri, Nitin
AU  - Puri N
AD  - Department of Physiology & Pharmacology, University of Toledo College of 
      Medicine, Toledo OH, USA.
FAU - Lakhani, Vishal H
AU  - Lakhani VH
AD  - Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall 
      University, Huntington, WV, USA.
FAU - Nichols, Alexandra
AU  - Nichols A
AD  - Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall 
      University, Huntington, WV, USA.
FAU - O'Hanlon, Kathleen M
AU  - O'Hanlon KM
AD  - Department of Family Medicine, Joan C. Edwards School of Medicine, Marshall 
      University, Huntington, WV, USA.
FAU - Abraham, Nader G
AU  - Abraham NG
AD  - Department of Pharmacology and Medicine, New York Medical College, The Touro 
      College and University System, Valhalla, NY, USA.
FAU - Shapiro, Joseph I
AU  - Shapiro JI
AD  - Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall 
      University, Huntington, WV, USA.
FAU - Sodhi, Komal
AU  - Sodhi K
AD  - Department of Surgery, Joan C. Edwards School of Medicine, Marshall University, 
      Huntington, WV, USA.
LA  - eng
GR  - R01 HL105649/HL/NHLBI NIH HHS/United States
GR  - R01 HL109015/HL/NHLBI NIH HHS/United States
GR  - U01 HL071556/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20170419
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adiponectin/blood
MH  - Adult
MH  - Biomarkers/*blood
MH  - Cardiovascular Diseases/blood/epidemiology/pathology
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/pathology
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Leptin/blood
MH  - Metabolic Syndrome/*blood/epidemiology/pathology
MH  - MicroRNAs/*blood
MH  - Obesity/*blood/epidemiology/pathology
MH  - Risk Factors
PMC - PMC5479123
OTO - NOTNLM
OT  - West Virginia.
OT  - metabolic syndrome
OT  - microRNA
OT  - serum biomarkers
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2017/06/24 06:00
MHDA- 2018/03/27 06:00
PMCR- 2017/01/01
CRDT- 2017/06/23 06:00
PHST- 2016/12/30 00:00 [received]
PHST- 2017/03/29 00:00 [accepted]
PHST- 2017/06/23 06:00 [entrez]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - ijmsv14p0543 [pii]
AID - 10.7150/ijms.18988 [doi]
PST - epublish
SO  - Int J Med Sci. 2017 Apr 19;14(6):543-553. doi: 10.7150/ijms.18988. eCollection 
      2017.