PMID- 28638450
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 8
IP  - 8
DP  - 2017
TI  - Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral 
      Squamous Cell Carcinoma.
PG  - 1362-1370
LID - 10.7150/jca.18031 [doi]
AB  - Mechanistic target of rapamycin (mTOR) plays a critical role in the development 
      of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain 
      poorly understood. Here we have demonstrated that the expression of osteopontin 
      (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, 
      reduction of OPN suppressed cell proliferation, colony formation, and in vivo 
      tumorigenic ability of OSCC cell lines Tca8113. In addition, there was a strong 
      positive correlation between mTORC1 activity and OPN expression in OSCC tissues 
      and cell lines. Furthermore, mTOR complex 1 (mTORC1) enhanced OPN expression 
      through up-regulation of ERRalpha. Therefore, OPN is a downstream target of mTORC1 
      and is crucial for OSCC development. mTORC1, ERRalpha, and OPN may be potential 
      targets for treatment of OSCC with aberrant mTORC1 signaling.
FAU - Gan, Ning
AU  - Gan N
AD  - Stomatological Hospital of Chongqing Medical University, Chongqing 401147, China.
AD  - Chongqing key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 
      401147, China.
AD  - Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher 
      Education, Chongqing 401147, China.
AD  - Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine 
      (Ministry of Education), Chongqing Medical University, Chongqing 400016, China.
FAU - Zou, Sihai
AU  - Zou S
AD  - Stomatological Hospital of Chongqing Medical University, Chongqing 401147, China.
AD  - Chongqing key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 
      401147, China.
AD  - Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher 
      Education, Chongqing 401147, China.
FAU - Hang, Wenming
AU  - Hang W
AD  - Stomatological Hospital of Chongqing Medical University, Chongqing 401147, China.
AD  - Chongqing key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 
      401147, China.
AD  - Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher 
      Education, Chongqing 401147, China.
FAU - Yang, Deqin
AU  - Yang D
AD  - Stomatological Hospital of Chongqing Medical University, Chongqing 401147, China.
AD  - Chongqing key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 
      401147, China.
AD  - Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher 
      Education, Chongqing 401147, China.
FAU - Zhang, Xuemei
AU  - Zhang X
AD  - Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine 
      (Ministry of Education), Chongqing Medical University, Chongqing 400016, China.
FAU - Yin, Yibing
AU  - Yin Y
AD  - Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine 
      (Ministry of Education), Chongqing Medical University, Chongqing 400016, China.
LA  - eng
PT  - Journal Article
DEP - 20170512
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC5479241
OTO - NOTNLM
OT  - ERRalpha
OT  - OPN
OT  - OSCC.
OT  - mTOR
OT  - tumorigenesis
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2017/06/24 06:00
MHDA- 2017/06/24 06:01
PMCR- 2017/01/01
CRDT- 2017/06/23 06:00
PHST- 2016/10/22 00:00 [received]
PHST- 2017/02/14 00:00 [accepted]
PHST- 2017/06/23 06:00 [entrez]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2017/06/24 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - jcav08p1362 [pii]
AID - 10.7150/jca.18031 [doi]
PST - epublish
SO  - J Cancer. 2017 May 12;8(8):1362-1370. doi: 10.7150/jca.18031. eCollection 2017.