PMID- 28640108
OWN - NLM
STAT- MEDLINE
DCOM- 20170717
LR  - 20220318
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 25
DP  - 2017 Jun
TI  - Correlation of HLA-DP/DQ polymorphisms with transplant etiologies and prognosis 
      in liver transplant recipients.
PG  - e7205
LID - 10.1097/MD.0000000000007205 [doi]
LID - e7205
AB  - Previous study has identified that the genetic variants in the human leukocyte 
      antigen (HLA)-DP/DQ region were strongly associated with hepatitis B virus (HBV) 
      infection. But their roles in liver function recovery after hepatic 
      transplantation were still obscure. This study aimed to investigate whether 
      HLA-DP/DQ polymorphisms were associated with post-transplant etiologies and 
      prognosis in Chinese liver transplant recipients.A total of 144 liver transplant 
      recipients were enrolled, which were divided into 2 groups according to the 
      transplant etiology: HBV-related disease and non-HBV-related disease. HBV-related 
      disease includes 3 subgroups: liver cirrhosis, hepatocellular carcinoma, and 
      progressive HBV hepatitis. Three single-nucleotide polymorphisms HLA-DP (rs3077 
      and rs9277535) and HLA-DQ (rs7453920) were studied in all recipients by 
      high-resolution melting curve analysis. Liver function indices (albumin, alanine 
      aminotransferase, aspartate aminotransferase, alkaline phosphatase, 
      gamma-glutamyltranspeptidase, direct bilirubin, total bilirubin) and coagulation 
      indices (prothrombin time, platelet, international normalized ratio, fibrinogen) 
      were routinely tested. After transplant, 10 recipients who were positive for 
      HBsAg or with elevation in HBV virus load were regarded as HBV recurrence.No 
      significant association of HLA-DP/DQ polymorphisms with HBV recurrence or 
      transplant etiology was observed (P < .05). Recipients with HLA-DQ (rs7453920) AG 
      and AA genotype had lower direct bilirubin levels than GG genotype individuals, 
      especially on the 14th day after surgery (17.80 vs. 5.35, P  =  .038). Patients 
      with A alleles displayed earlier liver function recovery than patients with G 
      alleles (7 vs. 6 months). No significant correlation was shown in HLA-DP rs3077 
      and rs9277535 with HBV infection or liver function recovery (P < .05).Our study 
      concluded that HLA-DP (rs3077 and rs9277535) and HLA-DQ (rs7453920) were not 
      significantly associated with HBV recurrence or HBV susceptibility, but HLA-DQ 
      rs7453920 was related to prognosis of liver transplant recipients. HLA-DQ 
      rs7453920 A might be used as an indicator of earlier recovery and better 
      prognosis after transplantation.
FAU - Li, Yi
AU  - Li Y
AD  - Department of Laboratory Medicine, Division of Clinical Immunology, West China 
      Hospital of Sichuan University West China School of Medicine, Sichuan University 
      Department of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Huang, Qian
AU  - Huang Q
FAU - Tang, Jiang-Tao
AU  - Tang JT
FAU - Wei, Tian-Tian
AU  - Wei TT
FAU - Yan, Lin
AU  - Yan L
FAU - Yang, Zhi-Qiang
AU  - Yang ZQ
FAU - Bai, Yang-Juan
AU  - Bai YJ
FAU - Wang, Lan-Lan
AU  - Wang LL
FAU - Shi, Yun-Ying
AU  - Shi YY
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - Hepatitis B/genetics/surgery
MH  - Hepatitis B virus
MH  - Humans
MH  - Liver Diseases/etiology/*genetics/*surgery/virology
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - Recurrence
MH  - Viral Load
PMC - PMC5484216
COIS- The authors report no conflicts of interest.
EDAT- 2017/06/24 06:00
MHDA- 2017/07/18 06:00
PMCR- 2017/06/23
CRDT- 2017/06/23 06:00
PHST- 2017/06/23 06:00 [entrez]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2017/07/18 06:00 [medline]
PHST- 2017/06/23 00:00 [pmc-release]
AID - 00005792-201706230-00037 [pii]
AID - MD-D-16-05169 [pii]
AID - 10.1097/MD.0000000000007205 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jun;96(25):e7205. doi: 10.1097/MD.0000000000007205.