PMID- 2864107
OWN - NLM
STAT- MEDLINE
DCOM- 19851112
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 344
IP  - 1
DP  - 1985 Sep 30
TI  - Monoamine-induced responses in lateral septal neurons: influence of 
      iontophoretically applied vasopressin.
PG  - 120-6
AB  - We examined the effect of iontophoretically applied noradrenaline (NA), dopamine 
      (DA) and serotonin (5-HT) on the spontaneous activity of lateral septal neurons 
      in rats and subsequently investigated if the observed responses to these 
      monoamines were altered in the presence of arginine8-vasopressin (AVP). NA, DA 
      and 5-HT induced a depression of the spontaneous activity in 70% of the 
      spontaneously active neurons on which they were tested. Of the remaining neurons 
      the majority was not affected by the monoamines. The responding cells differed 
      from the non-responding cells in their localization in those parts of the lateral 
      septum where dense monoamine-containing terminal networks have been visualized 
      and in their significantly lower spontaneous activity. The effect of AVP on 
      monoamine-induced responses was tested in neurons in which the spontaneous 
      activity was not affected by the peptide itself. It appeared that in about 30% of 
      these neurons, monoamine-induced inhibitions were reduced in presence of the 
      peptide whereas in the majority of the neurons responses to the monoamines were 
      not markedly altered by AVP. In contrast to this rather low occurrence of a clear 
      AVP-effect on the monoamine responses, the peptide enhanced excitatory responses 
      to glutamate in more than 75% of neurons tested during the same experiments. It 
      was concluded that under these experimental conditions the effect of AVP on 
      excitatory amino acid neurotransmission is more pronounced than on responses to 
      putative monoaminergic neurotransmitters in the lateral septum.
FAU - Joels, M
AU  - Joels M
FAU - Urban, I J
AU  - Urban IJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Biogenic Amines)
RN  - 0 (Glutamates)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 333DO1RDJY (Serotonin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*pharmacology
MH  - Biogenic Amines/*pharmacology
MH  - Dopamine/pharmacology
MH  - Drug Interactions
MH  - Glutamates/pharmacology
MH  - Glutamic Acid
MH  - Iontophoresis
MH  - Male
MH  - Norepinephrine/pharmacology
MH  - Rats
MH  - Septum Pellucidum/*drug effects
MH  - Serotonin/pharmacology
MH  - Synaptic Transmission/drug effects
EDAT- 1985/09/30 00:00
MHDA- 1985/09/30 00:01
CRDT- 1985/09/30 00:00
PHST- 1985/09/30 00:00 [pubmed]
PHST- 1985/09/30 00:01 [medline]
PHST- 1985/09/30 00:00 [entrez]
AID - 0006-8993(85)91195-3 [pii]
AID - 10.1016/0006-8993(85)91195-3 [doi]
PST - ppublish
SO  - Brain Res. 1985 Sep 30;344(1):120-6. doi: 10.1016/0006-8993(85)91195-3.