PMID- 28641491
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20231213
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 37
IP  - 5
DP  - 2018 May
TI  - Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and 
      neurobehavioral disorders in adult rat cerebral cortex().
PG  - 540-556
LID - 10.1177/0960327117698543 [doi]
AB  - BACKGROUND: Nicotine and cigarette smoking (CS) are associated with addiction 
      behavior, drug-seeking, and abuse. However, the mechanisms that mediate this 
      association especially, the role of brain-derived neurotrophic factor (BDNF), 
      dopamine (DA), and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling 
      in the cerebral cortex, are not fully known. Therefore, we hypothesized that 
      overexpression of BDNF and DA, and suppression of Nrf2 contribute to several 
      pathological and behavioral alterations in adult cerebral cortex. 
      Methodology/Principal Observations: We treated Wistar rats with different doses 
      of oral nicotine and passive CS for 4-week (short-term) and 12-week (long-term) 
      duration, where doses closely mimic the human smoking scenario. Our result showed 
      dose-dependent association of anxiogenic and depressive behavior, and cognitive 
      interference with neurodegeneration and DNA damage in the cerebral cortex upon 
      exposure to nicotine/CS as compared to the control. Further, the results are 
      linked to upregulation of oxidative stress, overexpression of BDNF, DA, and DA 
      marker, tyrosine hydroxylase (TH), with concomitant downregulation of ascorbate 
      and Nrf2 expression in the exposed cerebral cortex when compared with the 
      control. CONCLUSION/SIGNIFICANCE: Overall, our data strongly suggest that the 
      intervention of DA and BDNF, and depletion of antioxidants are important factors 
      during nicotine/CS-induced cerebral cortex pathological changes leading to 
      neurobehavioral impairments, which could underpin the novel therapeutic 
      approaches targeted at tobacco smoking/nicotine's neuropsychological disorders 
      including cognition and drug addiction.
FAU - Naha, Nibedita
AU  - Naha N
FAU - Gandhi, D N
AU  - Gandhi DN
AD  - DN Gandhi: Former scientist & Head, NBT Div., ICMR-NIOH.
FAU - Gautam, A K
AU  - Gautam AK
FAU - Prakash, J Ravi
AU  - Prakash JR
LA  - eng
PT  - Journal Article
DEP - 20170623
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Smoke)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 6M3C89ZY6R (Nicotine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Dopamine/*metabolism
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Nicotine/*toxicity
MH  - Rats, Wistar
MH  - Signal Transduction
MH  - Smoke/*adverse effects
MH  - *Nicotiana
MH  - Tobacco Smoke Pollution/*adverse effects
OTO - NOTNLM
OT  - BDNF
OT  - Nicotine
OT  - Nrf2
OT  - cerebral cortex behavior
OT  - cigarette smoking
OT  - dopamine
OT  - molecular mechanism
OT  - oxidative stress
EDAT- 2017/06/24 06:00
MHDA- 2018/09/25 06:00
CRDT- 2017/06/24 06:00
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2017/06/24 06:00 [entrez]
AID - 10.1177/0960327117698543 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2018 May;37(5):540-556. doi: 10.1177/0960327117698543. Epub 2017 
      Jun 23.