PMID- 28641524
OWN - NLM
STAT- MEDLINE
DCOM- 20200331
LR  - 20200331
IS  - 1873-5592 (Electronic)
IS  - 1389-4501 (Linking)
VI  - 20
IP  - 2
DP  - 2019
TI  - The Bio-Psycho-Social Dimension in Women's Sexual Desire: 'Argumentum ad 
      novitatem'.
PG  - 146-157
LID - 10.2174/1389450118666170622090337 [doi]
AB  - Sexual desire includes complex motivation and drive. In the context of biological 
      and cognitive- emotive state art of science, it is often a neglected field in 
      medicine. In regard to the treatment, study on women's sexual function received 
      less attention compared to the men's sexuality. In the past, this endeavor was 
      relatively not well disseminated in the scientific community. Recently, there was 
      a revolutionized surge of drug targets available to treat women with low sexual 
      desire. It is timely to review the relevant biological approach, especially in 
      the context of pharmacotherapy to understand this interesting clinical entity 
      which was modulated by numerous interactive psychosocial inter-play and factors. 
      The complex inter-play between numerous dimensional factors lends insights to 
      understand the neural mechanism, i.e. the rewards centre pathway and its 
      interaction with external psychosocialstimulus, e.g. relationship or other 
      meaningful life events. The function of hormones, e.g. oxytocin or testosterone 
      regulation was described. The role of neurotransmitters as reflected by the 
      introduction of a molecule of flibenserin, a full agonist of the 5-HT1A and 
      partial agonist of the D4 to treat premenopausal women with low sexual desire was 
      deliberated. Based on this fundamental scientific core knowledge, we suggest an 
      outline on know-how of introduction for sex therapy (i.e. "inner-self" and 
      "outer-self") where the role of partner is narrated. Then, we also highlighted on 
      the use of pharmacological agent as an adjunct scope of therapy, i.e. 
      phosphodiasterase-5 (PDE-5) inhibitors and hormonal treatment in helping the 
      patient with low sexual desire.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Roslan, Nur Syazwani
AU  - Roslan NS
AD  - Department of Psychiatry, Universiti Kebangsaan Malaysia Medical Centre, 56000 
      Cheras, Kuala Lumpur, Malaysia.
FAU - Jaafar, Nik Ruzyanei Nik
AU  - Jaafar NRN
AD  - Department of Psychiatry, Universiti Kebangsaan Malaysia Medical Centre, 56000 
      Cheras, Kuala Lumpur, Malaysia.
FAU - Sidi, Hatta
AU  - Sidi H
AD  - Department of Psychiatry, Universiti Kebangsaan Malaysia Medical Centre, 56000 
      Cheras, Kuala Lumpur, Malaysia.
FAU - Baharudin, Najwa
AU  - Baharudin N
AD  - Department of Psychiatry, Universiti Kebangsaan Malaysia Medical Centre, 56000 
      Cheras, Kuala Lumpur, Malaysia.
FAU - Kumar, Jaya
AU  - Kumar J
AD  - Department of Physiology, Universiti Kebangsaan Malaysia Medical Centre, 56000 
      Cheras, Kuala Lumpur, Malaysia.
FAU - Das, Srijit
AU  - Das S
AD  - Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, 56000 
      Cheras, Kuala Lumpur, Malaysia.
FAU - Hussain, Nik Hazlina Nik
AU  - Hussain NHN
AD  - Women's Health Development Unit, School of Medical Sciences, Universiti Sains 
      Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Targets
JT  - Current drug targets
JID - 100960531
RN  - 0 (Hormones)
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - Female
MH  - Hormones/*metabolism
MH  - Humans
MH  - Libido
MH  - Neurotransmitter Agents/pharmacology/therapeutic use
MH  - Psychotherapy
MH  - Sexual Behavior/drug effects/*psychology
MH  - Sexual Dysfunctions, Psychological/metabolism/*therapy
MH  - Women's Health
OTO - NOTNLM
OT  - Female sexual desire
OT  - PDE-5 inhibitor
OT  - flibanserin
OT  - low sexual desire
OT  - neural basis
OT  - psychosocial dimension.
EDAT- 2017/06/24 06:00
MHDA- 2020/04/01 06:00
CRDT- 2017/06/24 06:00
PHST- 2017/02/23 00:00 [received]
PHST- 2017/06/08 00:00 [revised]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2020/04/01 06:00 [medline]
PHST- 2017/06/24 06:00 [entrez]
AID - CDT-EPUB-84323 [pii]
AID - 10.2174/1389450118666170622090337 [doi]
PST - ppublish
SO  - Curr Drug Targets. 2019;20(2):146-157. doi: 10.2174/1389450118666170622090337.