PMID- 28641905
OWN - NLM
STAT- MEDLINE
DCOM- 20180820
LR  - 20221207
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 45
IP  - 1
DP  - 2018 Feb
TI  - High Gpx1 expression predicts poor survival in laryngeal squamous cell carcinoma.
PG  - 13-19
LID - S0385-8146(17)30299-7 [pii]
LID - 10.1016/j.anl.2017.05.012 [doi]
AB  - OBJECTIVE: Several studies have demonstrated that abnormal glutathione 
      peroxidases 1 (Gpx1) expression can influence the biological behavior of 
      malignant cells. However, the roles of Gpx1 in laryngeal squamous cell carcinoma 
      (LSCC) remain unknown. The purpose of this study is to analyze the Gpx1 
      expression and prognostic significance in LSCC patients. METHODS: Gpx1 mRNA 
      levels in laryngeal tissues were determined by qRT-PCR. Meanwhile, We examined 
      the expression levels of Gpx1 protein in 140 primary tumor tissues and 28 cases 
      of normal tissues by immunohistochemistry (IHC) analysis on tissue microarrays 
      (TMA). RESULTS: Our results revealed that the frequency of high Gpx1 was 
      significantly higher in cancer tissue compared to normal surgical margins; Gpx1 
      expression correlated with clinical features and overall survival (OS). Gpx1 
      overexpression was significantly associated with lymph node metastasis (P=0.023) 
      and TNM stage (P=0.008); Kaplan-Meier survival curves revealed that patients with 
      high Gpx1 expression had worse prognoses than patients with low Gpx1 expression; 
      By multivariate analysis, we revealed that high Gpx1 expression level (HR 2.101, 
      95%CI 1.011-4.367; P=0.047) was an independent prognostic factor of survival in 
      LSCC patients. CONCLUSION: We speculate that Gpx1 can be applied to predict the 
      prognosis in LSCC patients.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Zhang, Qicheng
AU  - Zhang Q
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Second Clinical 
      Medical College of Nanjing Medical University, Nanjing, Jiangsu Province, China; 
      Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of 
      Nantong University, Nantong, Jiangsu Province, China.
FAU - Xu, Hongli
AU  - Xu H
AD  - Department of Neurology, The Third People's Hospital of Nantong, Nantong, Jiangsu 
      Province, China.
FAU - You, Yiwen
AU  - You Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of 
      Nantong University, Nantong, Jiangsu Province, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of 
      Nantong University, Nantong, Jiangsu Province, China.
FAU - Chen, Renjie
AU  - Chen R
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The Second Clinical 
      Medical College of Nanjing Medical University, Nanjing, Jiangsu Province, China; 
      Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated 
      Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. 
      Electronic address: rjchen_ent@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170620
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (RNA, Messenger)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase GPX1)
RN  - EC 1.11.1.9 (GPX1 protein, human)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/mortality
MH  - Glutathione Peroxidase/genetics/*metabolism
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*metabolism/mortality
MH  - Larynx/*metabolism
MH  - Multivariate Analysis
MH  - Prognosis
MH  - RNA, Messenger/metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Glutathione Peroxidase GPX1
OTO - NOTNLM
OT  - Gpx1
OT  - Laryngeal squamous cell carcinoma
OT  - Prognosis
OT  - Tissue microarrays (TMA)
EDAT- 2017/06/24 06:00
MHDA- 2018/08/21 06:00
CRDT- 2017/06/24 06:00
PHST- 2017/03/26 00:00 [received]
PHST- 2017/04/24 00:00 [revised]
PHST- 2017/05/29 00:00 [accepted]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2018/08/21 06:00 [medline]
PHST- 2017/06/24 06:00 [entrez]
AID - S0385-8146(17)30299-7 [pii]
AID - 10.1016/j.anl.2017.05.012 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2018 Feb;45(1):13-19. doi: 10.1016/j.anl.2017.05.012. Epub 
      2017 Jun 20.