PMID- 2864263
OWN - NLM
STAT- MEDLINE
DCOM- 19851112
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 113
IP  - 1
DP  - 1985 Jul 11
TI  - Role of cholinergic neurons in the cardiovascular responses evoked by central 
      injection of bradykinin or angiotensin II in conscious rats.
PG  - 43-51
AB  - Intracerebroventricular (i.c.v.) injection of bradykinin (0.1-10 micrograms) or 
      angiotensin II (0.01-10 micrograms) in conscious, freely moving rats evoked 
      dose-related increases in arterial pressure. The pressor response to bradykinin 
      (BK) was accompanied by an increase in heart rate while angiotensin II (ANG II) 
      decreased heart rate. Pretreatment with hemicholinium-3 to deplete brain 
      acetylcholine levels produced a choline-reversible blockade of the cardiovascular 
      response to BK. In contrast, the pressor response to ANG II was only weakly 
      inhibited by hemicholinium-3 and the bradycardia was unaffected. Central 
      pretreatment with the nicotinic antagonist, hexamethonium (50 micrograms) was 
      more effective than the muscarinic antagonist atropine (20 micrograms) at 
      blocking the cardiovascular responses to i.c.v. injection of BK. Both blocking 
      agents produced a weaker inhibitory effect on the pressor response to ANG II 
      although no anticholinergic pretreatment significantly inhibited the fall in 
      heart rate. These results are consistent with the possibility of a 
      peptidergic-cholinergic interaction in the central cardiovascular actions of BK 
      and perhaps for a component of the pressor response to ANG II.
FAU - Buccafusco, J J
AU  - Buccafusco JJ
FAU - Serra, M
AU  - Serra M
LA  - eng
GR  - HL 30046/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Hexamethonium Compounds)
RN  - 11128-99-7 (Angiotensin II)
RN  - 312-45-8 (Hemicholinium 3)
RN  - 3C9PSP36Z2 (Hexamethonium)
RN  - 7C0697DR9I (Atropine)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Atropine/pharmacology
MH  - Blood Pressure/*drug effects
MH  - Bradykinin/*pharmacology
MH  - Brain/*drug effects
MH  - Female
MH  - Heart Rate/*drug effects
MH  - Hemicholinium 3/pharmacology
MH  - Hexamethonium
MH  - Hexamethonium Compounds/pharmacology
MH  - Male
MH  - Parasympathetic Nervous System/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1985/07/11 00:00
MHDA- 1985/07/11 00:01
CRDT- 1985/07/11 00:00
PHST- 1985/07/11 00:00 [pubmed]
PHST- 1985/07/11 00:01 [medline]
PHST- 1985/07/11 00:00 [entrez]
AID - 0014-2999(85)90341-3 [pii]
AID - 10.1016/0014-2999(85)90341-3 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1985 Jul 11;113(1):43-51. doi: 10.1016/0014-2999(85)90341-3.