PMID- 28643476
OWN - NLM
STAT- MEDLINE
DCOM- 20191001
LR  - 20191008
IS  - 1365-2869 (Electronic)
IS  - 0962-1105 (Print)
IS  - 0962-1105 (Linking)
VI  - 27
IP  - 2
DP  - 2018 Apr
TI  - Low leptin concentration may identify heart failure patients with central sleep 
      apnea.
PG  - 240-243
LID - 10.1111/jsr.12574 [doi]
AB  - Low leptin concentration has been shown to be associated with central sleep apnea 
      in heart failure patients. We hypothesized that low leptin concentration predicts 
      central sleep apnea. Consecutive ambulatory New York Heart Association (NYHA) 
      classes I-IV heart failure patients were studied prospectively, including 
      measurement of serum leptin, echocardiography and polysomnography. Sleep apnea 
      was defined by type (central/mixed/obstructive) and by apnea-hypopnea index >/=5 by 
      polysomnography. Subjects were divided into four groups by polysomnography: (1) 
      central sleep apnea, (2) mixed apnea, (3) no apnea and (4) obstructive sleep 
      apnea. Fifty-six subjects were included. Eighteen subjects were diagnosed with 
      central sleep apnea, 15 with mixed apnea, 12 with obstructive apnea and 11 with 
      no sleep apnea. Leptin concentration was significantly lower in central sleep 
      apnea compared to obstructive apnea (8 +/- 10.7 ng mL(-1) versus 
      19.7 +/- 14.7 ng mL(-1) , P < 0.01) or no sleep apnea (8 +/- 10.7 ng mL(-1) versus 
      17.1 +/- 8.4 ng mL(-1) , P < 0.01). Logistic regression showed leptin to be 
      associated independently with central sleep apnea [odds ratio (OR): 0.19; 95% 
      confidence interval (CI): 0.06-0.62; area under the curve (AUC): 0.80, P < 0.01]. 
      For the detection of central sleep apnea, a cut-off value for leptin 
      concentration 5 ng mL(-1) yielded a sensitivity of 50% and specificity of 89%. In 
      conclusion, a low leptin concentration may have utility for the screening of 
      heart failure patients for central sleep apnea.
CI  - (c) 2017 European Sleep Research Society.
FAU - Cundrle, Ivan Jr
AU  - Cundrle I Jr
AUID- ORCID: 0000-0002-7709-8021
AD  - International Clinical Research Center and Department of Anesthesiology and 
      Intensive Care, St. Anne's University Hospital, Brno, Czech Republic.
FAU - Somers, Virend K
AU  - Somers VK
AD  - Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
FAU - Singh, Prachi
AU  - Singh P
AD  - Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
FAU - Johnson, Bruce D
AU  - Johnson BD
AD  - Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
FAU - Scott, Christopher G
AU  - Scott CG
AD  - Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 
      USA.
FAU - Olson, Lyle J
AU  - Olson LJ
AUID- ORCID: 0000-0002-3185-1305
AD  - Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
LA  - eng
GR  - R01 HL065176/HL/NHLBI NIH HHS/United States
GR  - R01 HL071478/HL/NHLBI NIH HHS/United States
GR  - UL1 RR024150/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170623
PL  - England
TA  - J Sleep Res
JT  - Journal of sleep research
JID - 9214441
RN  - 0 (Biomarkers)
RN  - 0 (Leptin)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Female
MH  - Heart Failure/*blood/*diagnostic imaging/epidemiology
MH  - Humans
MH  - Leptin/*blood
MH  - Male
MH  - Middle Aged
MH  - Polysomnography/methods
MH  - Prospective Studies
MH  - Sleep Apnea, Central/*blood/*diagnostic imaging/epidemiology
PMC - PMC5742087
MID - NIHMS877689
OTO - NOTNLM
OT  - central sleep apnea
OT  - heart failure
OT  - leptin
OT  - screening
COIS- Conflicts of interest: IC, PS, BDJ, CGS and LJO none. VS has served as a 
      Consultant for ResMed, Philips Respironics, Glaxo Smith Kline, Sorin, 
      Respicardia, Ronda Grey, and SAPCOA, and has been an investigator on studies 
      funded by a gift to the Mayo Foundation from the Philips Respironics Foundation.
EDAT- 2017/06/24 06:00
MHDA- 2019/10/02 06:00
PMCR- 2019/04/01
CRDT- 2017/06/24 06:00
PHST- 2017/02/10 00:00 [received]
PHST- 2017/05/14 00:00 [accepted]
PHST- 2017/04/13 00:00 [revised]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2019/10/02 06:00 [medline]
PHST- 2017/06/24 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 10.1111/jsr.12574 [doi]
PST - ppublish
SO  - J Sleep Res. 2018 Apr;27(2):240-243. doi: 10.1111/jsr.12574. Epub 2017 Jun 23.