PMID- 28645061
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20181202
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 178
DP  - 2017 Sep 1
TI  - The neurochemical consequences of methamphetamine self-administration in male and 
      female rats.
PG  - 70-74
LID - S0376-8716(17)30250-8 [pii]
LID - 10.1016/j.drugalcdep.2017.04.011 [doi]
AB  - BACKGROUND: Methamphetamine (METH) is an addictive substance that is used in both 
      males and females. Few preclinical studies have focused on understanding 
      sex-differences in the neurochemical consequences of contingent METH. The purpose 
      of the current study was to investigate potential sex-differences in the 
      neurochemical consequences of METH self-administration. METHODS: Male and female 
      adult rats were given extended access to METH or saline self-administration for 
      7d. Following self-administration, hippocampal brain-derived neurotrophic factor 
      (BDNF) and striatal dopamine transporter (DAT) were assessed via western 
      blotting. RESULTS: Male and female rats had similar METH intake. METH 
      self-administration reduced striatal DAT in both sexes, but only males that 
      self-administered METH had elevated hippocampal BDNF levels. CONCLUSIONS: 
      Sex-differences exist in the neurochemical consequences of METH 
      self-administration. These differences may lead to sex-specific vulnerability to 
      the toxic effects of METH.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Johansen, Andrew
AU  - Johansen A
AD  - Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 
      84103, United States.
FAU - McFadden, Lisa M
AU  - McFadden LM
AD  - Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 
      84103, United States; Division of Basic Biomedical Sciences, University of South 
      Dakota, Vermillion, SD 57069, United States. Electronic address: 
      lisa.mcfadden@usd.edu.
LA  - eng
GR  - K99 DA036012/DA/NIDA NIH HHS/United States
GR  - R00 DA036012/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20170606
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 44RAL3456C (Methamphetamine)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/chemistry/*metabolism
MH  - Corpus Striatum/*metabolism
MH  - Dopamine Plasma Membrane Transport Proteins/chemistry/*metabolism
MH  - Female
MH  - Hippocampus/*drug effects
MH  - Male
MH  - Methamphetamine/chemistry/*pharmacology
MH  - Rats
MH  - Self Administration
MH  - Substance-Related Disorders/*physiopathology/psychology
PMC - PMC5597241
MID - NIHMS882568
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Dopamine transporter
OT  - Female
OT  - Methamphetamine
OT  - Self-administration
COIS- Conflict of Interest No conflict declared.
EDAT- 2017/06/24 06:00
MHDA- 2018/03/27 06:00
PMCR- 2018/09/01
CRDT- 2017/06/24 06:00
PHST- 2016/11/15 00:00 [received]
PHST- 2017/04/05 00:00 [revised]
PHST- 2017/04/10 00:00 [accepted]
PHST- 2017/06/24 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/06/24 06:00 [entrez]
PHST- 2018/09/01 00:00 [pmc-release]
AID - S0376-8716(17)30250-8 [pii]
AID - 10.1016/j.drugalcdep.2017.04.011 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2017 Sep 1;178:70-74. doi: 10.1016/j.drugalcdep.2017.04.011. 
      Epub 2017 Jun 6.