PMID- 28645654
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 0925-4439 (Print)
IS  - 0925-4439 (Linking)
VI  - 1864
IP  - 4 Pt B
DP  - 2018 Apr
TI  - Epigenome dysregulation in cholangiocarcinoma.
PG  - 1423-1434
LID - S0925-4439(17)30209-0 [pii]
LID - 10.1016/j.bbadis.2017.06.014 [doi]
AB  - Epigenomics is a fast-evolving field of research that has lately attracted 
      considerable interest, mainly due to the reversibility of epigenetic marks. 
      Clinically, among solid tumors, the field is still limited. In cholangiocarcinoma 
      (CCA) it is well known that the epigenetic landscape is deregulated both during 
      carcinogenesis and disease progression as a consequence of aberrant mechanisms 
      leading to genome instability. In this article, we will briefly review the 
      molecular alterations that have been described in the transformation of normal 
      cholangiocytes into malignant derivatives, focusing on the role of non-coding RNA 
      (ncRNA) interactions, DNA methylation, post-translational modifications (PTMs) of 
      histones and chromatin remodeling complexes.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - O'Rourke, Colm J
AU  - O'Rourke CJ
AD  - Biotech Research & Innovation Centre (BRIC), Department of Health and Medical 
      Sciences, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen N, 
      Denmark.
FAU - Munoz-Garrido, Patricia
AU  - Munoz-Garrido P
AD  - Biotech Research & Innovation Centre (BRIC), Department of Health and Medical 
      Sciences, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen N, 
      Denmark.
FAU - Aguayo, Esmeralda L
AU  - Aguayo EL
AD  - Biotech Research & Innovation Centre (BRIC), Department of Health and Medical 
      Sciences, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen N, 
      Denmark.
FAU - Andersen, Jesper B
AU  - Andersen JB
AD  - Biotech Research & Innovation Centre (BRIC), Department of Health and Medical 
      Sciences, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen N, 
      Denmark. Electronic address: jesper.andersen@bric.ku.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170620
PL  - Netherlands
TA  - Biochim Biophys Acta Mol Basis Dis
JT  - Biochimica et biophysica acta. Molecular basis of disease
JID - 101731730
RN  - 0 (Histones)
RN  - 0 (RNA, Untranslated)
SB  - IM
MH  - Bile Duct Neoplasms/*genetics/pathology
MH  - Bile Ducts/cytology/pathology
MH  - Cell Transformation, Neoplastic/genetics
MH  - Cholangiocarcinoma/*genetics/pathology
MH  - Chromatin Assembly and Disassembly/genetics
MH  - DNA Methylation/genetics
MH  - Disease Progression
MH  - *Epigenesis, Genetic
MH  - Epithelial Cells/pathology
MH  - *Gene Expression Regulation, Neoplastic
MH  - Genomic Instability
MH  - Histones/genetics
MH  - Humans
MH  - Protein Processing, Post-Translational/genetics
MH  - RNA, Untranslated/genetics
OTO - NOTNLM
OT  - Biliary tract
OT  - Cholangiocarcinoma
OT  - Dysregulation
OT  - Epigenetics
OT  - Epigenome
EDAT- 2017/06/25 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/06/25 06:00
PHST- 2017/05/10 00:00 [received]
PHST- 2017/06/18 00:00 [accepted]
PHST- 2017/06/25 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/06/25 06:00 [entrez]
AID - S0925-4439(17)30209-0 [pii]
AID - 10.1016/j.bbadis.2017.06.014 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1423-1434. doi: 
      10.1016/j.bbadis.2017.06.014. Epub 2017 Jun 20.