PMID- 28645657
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20170817
IS  - 1879-0291 (Electronic)
IS  - 0141-1136 (Linking)
VI  - 129
DP  - 2017 Aug
TI  - Gross pathology, physiological and toxicological responses in relation to metals 
      and persistent organic pollutants (POPs) burden in tilapia species from Ogun 
      River, Nigeria.
PG  - 245-257
LID - S0141-1136(17)30220-9 [pii]
LID - 10.1016/j.marenvres.2017.06.003 [doi]
AB  - We have investigated gross pathology, physiological (steroid precursors) and 
      toxicological responses (oxidative stress and phase II biotransformation) in 
      relation to tissue contaminant burden in Tilapia species along the entire length 
      (320 km) of Ogun River, Nigeria. The Ogun River is the longest and largest river 
      in Southwestern Nigeria located along heavily industrialized cities and receives 
      complex mixtures of effluents. A total of 1074 tilapias were collected from three 
      sampling points (Abeokuta, Isheri and Ikorodu) and from an upstream control point 
      (Igboho) and evaluated for gross pathological changes, hepatic transcript levels 
      for oxidative stress and phase II biotransformation responses. Trace metal 
      concentrations and POPs in muscle samples were analyzed using ICP-MS and GC-MS 
      respectively. Evaluation of gross pathological changes showed a 50-, 33-, 17 and 
      0% prevalence of hepatic tumors at the Ikorodu, Abeokuta, Isheri and Igboho 
      sites, respectively. Plasma concentrations of cholesterol and pregnenolone showed 
      apparent significant decreases at downstream sites of the control point in both 
      male and female fish (except for pregnenolone levels of male fish at Ikorodu). 
      Inversely, gst, ugt-1, ZuCu-sod and sod significantly increased in fish collected 
      from downstream sites, compared with the control site and these increases 
      paralleled the significant increase in trace metal and POPs concentrations at 
      these sites. PCA revealed a site related association between measured 
      toxicological responses and contaminant burden, indicating a potential 
      cause-and-effect relationship. Thus, the possible adaptation of Ogun River 
      Tilapia species to contaminants may have significant consequences on cellular, 
      physiological and biochemical processes regulating metabolism, growth, 
      development and reproduction, and also have serious human health consequences, 
      since the Ogun River is used for fisheries and domestic water supply for 
      surrounding neighborhoods.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Ibor, Oju R
AU  - Ibor OR
AD  - Department of Zoology, University of Ibadan, Ibadan, Nigeria; Department of 
      Zoology and Environmental Biology, University of Calabar, Calabar, Nigeria.
FAU - Adeogun, Aina O
AU  - Adeogun AO
AD  - Department of Zoology, University of Ibadan, Ibadan, Nigeria.
FAU - Chukwuka, Azubuike V
AU  - Chukwuka AV
AD  - Department of Zoology, University of Ibadan, Ibadan, Nigeria.
FAU - Arukwe, Augustine
AU  - Arukwe A
AD  - Department of Biology, Norwegian University of Science and Technology (NTNU), 
      Hogskoleringen 5, N-7491 Trondheim, Norway. Electronic address: 
      arukwe@bio.ntnu.no.
LA  - eng
PT  - Journal Article
DEP - 20170608
PL  - England
TA  - Mar Environ Res
JT  - Marine environmental research
JID - 9882895
RN  - 0 (Complex Mixtures)
RN  - 0 (Metals)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Complex Mixtures/analysis/toxicity
MH  - *Environmental Monitoring
MH  - Female
MH  - Liver/metabolism
MH  - Male
MH  - Metals/analysis/*toxicity
MH  - Nigeria
MH  - Oxidative Stress
MH  - Rivers
MH  - Tilapia/*physiology
MH  - Water Pollutants, Chemical/analysis/*toxicity
OTO - NOTNLM
OT  - Heavy metal
OT  - Ogun river
OT  - Organic pollutants
OT  - Tilapias
OT  - Toxicological and physiological responses
OT  - Tropical ecosystems
EDAT- 2017/06/25 06:00
MHDA- 2017/08/18 06:00
CRDT- 2017/06/25 06:00
PHST- 2017/04/04 00:00 [received]
PHST- 2017/05/31 00:00 [revised]
PHST- 2017/06/07 00:00 [accepted]
PHST- 2017/06/25 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
PHST- 2017/06/25 06:00 [entrez]
AID - S0141-1136(17)30220-9 [pii]
AID - 10.1016/j.marenvres.2017.06.003 [doi]
PST - ppublish
SO  - Mar Environ Res. 2017 Aug;129:245-257. doi: 10.1016/j.marenvres.2017.06.003. Epub 
      2017 Jun 8.