PMID- 28645691
OWN - NLM
STAT- MEDLINE
DCOM- 20170731
LR  - 20180104
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 329
DP  - 2017 Aug 15
TI  - Maternal exposure to a mixture of persistent organic pollutants (POPs) affects 
      testis histology, epididymal sperm count and induces sperm DNA fragmentation in 
      mice.
PG  - 301-308
LID - S0041-008X(17)30275-2 [pii]
LID - 10.1016/j.taap.2017.06.019 [doi]
AB  - Persistent organic pollutants (POPs) are widespread throughout the environment 
      and some are suspected to induce reproductive toxicity. As animals and humans are 
      exposed to complex mixtures of POPs, it is reasonable to assess how such mixtures 
      could interact with the reproductive system. Our aim is to investigate how 
      maternal exposure to a mixture of 29 different persistent organic pollutants, 
      formulated to mimic the relative POP levels in the food basket of the 
      Scandinavian population, could alter reproductive endpoints. Female mice were 
      exposed via feed from weaning, during pregnancy and lactation in 3 exposure 
      groups (control (C), low (L) and high (H)). Testicular morphometric endpoints, 
      epididymal sperm concentration and sperm DNA integrity were assessed in adult 
      male offspring. We found that the number of tubules, proportion of tubule 
      compartments and epididymal sperm concentration significantly decreased in both 
      POP exposed groups. Epididymal sperm from both POP exposed groups showed 
      increased DNA fragmentation. It is concluded that maternal exposure to a defined 
      POP mixture relevant to human exposure can affect testicular development, sperm 
      production and sperm chromatin integrity.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Khezri, Abdolrahman
AU  - Khezri A
AD  - Department of Basic Science and Aquatic Medicine, Faculty of Veterinary Medicine, 
      Norwegian University of Life Science, Pb. 8146 Dep, 0033 Oslo, Norway. Electronic 
      address: Abdolrahman.Khezri@nmbu.no.
FAU - Lindeman, Birgitte
AU  - Lindeman B
AD  - Department of Toxicology and Risk, Norwegian Institute of Public Health, Pb 4404, 
      0403 Oslo, Norway. Electronic address: Birgitte.Lindeman@fhi.no.
FAU - Krogenaes, Anette K
AU  - Krogenaes AK
AD  - Department of Production Animal Clinical Science, Faculty of Veterinary Medicine, 
      Norwegian University of Life Science, Pb. 8146 Dep, 0033 Oslo, Norway. Electronic 
      address: Anette.Krogenaes@nmbu.no.
FAU - Berntsen, Hanne F
AU  - Berntsen HF
AD  - Norwegian National Institute of Occupational Health, Pb. 8149 Dep, 0033 Oslo, 
      Norway. Electronic address: Hanne.Berntsen@stami.no.
FAU - Zimmer, Karin E
AU  - Zimmer KE
AD  - Department of Basic Science and Aquatic Medicine, Faculty of Veterinary Medicine, 
      Norwegian University of Life Science, Pb. 8146 Dep, 0033 Oslo, Norway. Electronic 
      address: Karin.Zimmer@nmbu.no.
FAU - Ropstad, Erik
AU  - Ropstad E
AD  - Department of Production Animal Clinical Science, Faculty of Veterinary Medicine, 
      Norwegian University of Life Science, Pb. 8146 Dep, 0033 Oslo, Norway. Electronic 
      address: Erik.Ropstad@nmbu.no.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170620
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Animals
MH  - Chromatin Assembly and Disassembly/drug effects
MH  - *DNA Fragmentation
MH  - Environmental Pollutants/*toxicity
MH  - Epididymis/*drug effects/metabolism/pathology
MH  - Female
MH  - Lactation
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Mice
MH  - Mice, 129 Strain
MH  - Mice, Inbred C57BL
MH  - Organic Chemicals/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Reproduction/*drug effects
MH  - Risk Assessment
MH  - Sex Factors
MH  - *Sperm Count
MH  - Spermatozoa/*drug effects/metabolism/pathology
MH  - Testis/*drug effects/metabolism/pathology
MH  - Weaning
OTO - NOTNLM
OT  - Persistent organic pollutants (POPs) mixture
OT  - Reproductive toxicity
OT  - Sperm chromatin structure assay (SCSA)
OT  - Sperm count
OT  - Testis histology
EDAT- 2017/06/25 06:00
MHDA- 2017/08/02 06:00
CRDT- 2017/06/25 06:00
PHST- 2016/12/13 00:00 [received]
PHST- 2017/06/14 00:00 [revised]
PHST- 2017/06/20 00:00 [accepted]
PHST- 2017/06/25 06:00 [pubmed]
PHST- 2017/08/02 06:00 [medline]
PHST- 2017/06/25 06:00 [entrez]
AID - S0041-008X(17)30275-2 [pii]
AID - 10.1016/j.taap.2017.06.019 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2017 Aug 15;329:301-308. doi: 10.1016/j.taap.2017.06.019. 
      Epub 2017 Jun 20.