PMID- 28645841
OWN - NLM
STAT- MEDLINE
DCOM- 20180528
LR  - 20180904
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 157
DP  - 2017 Aug 15
TI  - How do self-interest and other-need interact in the brain to determine altruistic 
      behavior?
PG  - 598-611
LID - S1053-8119(17)30509-8 [pii]
LID - 10.1016/j.neuroimage.2017.06.040 [doi]
AB  - Altruistic behavior, i.e., promoting the welfare of others at a cost to oneself, 
      is subserved by the integration of various social, affective, and economic 
      factors represented in extensive brain regions. However, it is unclear how 
      different regions interact to process/integrate information regarding the 
      helper's interest and recipient's need when deciding whether to behave 
      altruistically. Here we combined an interactive game with functional Magnetic 
      Resonance Imaging (fMRI) and transcranial direct current stimulation (tDCS) to 
      characterize the neural network underlying the processing/integration of 
      self-interest and other-need. At the behavioral level, high self-risk decreased 
      helping behavior and high other-need increased helping behavior. At the neural 
      level, activity in medial prefrontal cortex (MPFC) and right dorsolateral 
      prefrontal cortex (rDLPFC) were positively associated with self-risk levels, and 
      activity in right inferior parietal lobe (rIPL) and rDLPFC were negatively 
      associated with other-need levels. Dynamic causal modeling further suggested that 
      both MPFC and rIPL were extrinsically connected to rDLPFC; high self-risk 
      enhanced the effective connectivity from MPFC to rDLPFC, and the modulatory 
      effect of other-need on the connectivity from rIPL to rDLPFC positively 
      correlated with the modulatory effect of other-need on individuals' helping rate. 
      Two tDCS experiments provided causal evidence that rDLPFC affects both 
      self-interest and other-need concerns, and rIPL selectively affects the 
      other-need concerns. These findings suggest a crucial role of the MPFC-IPL-DLPFC 
      network during altruistic decision-making, with rDLPFC as a central node for 
      integrating and modulating motives regarding self-interest and other-need.
CI  - Copyright (c) 2017. Published by Elsevier Inc.
FAU - Hu, Jie
AU  - Hu J
AD  - Center for Brain and Cognitive Sciences, Peking University, Beijing 100871, 
      China; School of Psychological and Cognitive Sciences, Peking University, Beijing 
      100871, China.
FAU - Li, Yue
AU  - Li Y
AD  - Center for Brain and Cognitive Sciences, Peking University, Beijing 100871, 
      China; School of Psychological and Cognitive Sciences, Peking University, Beijing 
      100871, China.
FAU - Yin, Yunlu
AU  - Yin Y
AD  - Center for Brain and Cognitive Sciences, Peking University, Beijing 100871, 
      China; School of Psychological and Cognitive Sciences, Peking University, Beijing 
      100871, China.
FAU - Blue, Philip R
AU  - Blue PR
AD  - Center for Brain and Cognitive Sciences, Peking University, Beijing 100871, 
      China; School of Psychological and Cognitive Sciences, Peking University, Beijing 
      100871, China.
FAU - Yu, Hongbo
AU  - Yu H
AD  - Center for Brain and Cognitive Sciences, Peking University, Beijing 100871, 
      China; School of Psychological and Cognitive Sciences, Peking University, Beijing 
      100871, China.
FAU - Zhou, Xiaolin
AU  - Zhou X
AD  - Center for Brain and Cognitive Sciences, Peking University, Beijing 100871, 
      China; School of Psychological and Cognitive Sciences, Peking University, Beijing 
      100871, China; Key Laboratory of Machine Perception (Ministry of Education), 
      Peking University, Beijing 100871, China; Beijing Key Laboratory of Behavior and 
      Mental Health, Peking University, Beijing, China; PKU-IDG/McGovern Institute for 
      Brain Research, Peking University, Beijing 100871, China. Electronic address: 
      xz104@pku.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170620
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Altruism
MH  - Brain Mapping/*methods
MH  - Female
MH  - *Helping Behavior
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Parietal Lobe/diagnostic imaging/*physiology
MH  - Prefrontal Cortex/diagnostic imaging/*physiology
MH  - *Risk-Taking
MH  - Transcranial Direct Current Stimulation/*methods
MH  - Young Adult
EDAT- 2017/06/25 06:00
MHDA- 2018/05/29 06:00
CRDT- 2017/06/25 06:00
PHST- 2016/12/21 00:00 [received]
PHST- 2017/06/09 00:00 [revised]
PHST- 2017/06/16 00:00 [accepted]
PHST- 2017/06/25 06:00 [pubmed]
PHST- 2018/05/29 06:00 [medline]
PHST- 2017/06/25 06:00 [entrez]
AID - S1053-8119(17)30509-8 [pii]
AID - 10.1016/j.neuroimage.2017.06.040 [doi]
PST - ppublish
SO  - Neuroimage. 2017 Aug 15;157:598-611. doi: 10.1016/j.neuroimage.2017.06.040. Epub 
      2017 Jun 20.