PMID- 28645861
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20180507
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 134
DP  - 2017 Sep
TI  - Protective effect of Lycium Barbarum polysaccharides on dextromethorphan-induced 
      mood impairment and neurogenesis suppression.
PG  - 10-17
LID - S0361-9230(17)30144-2 [pii]
LID - 10.1016/j.brainresbull.2017.06.014 [doi]
AB  - Dextromethorphan (DXM) is one of the common drugs abused by adolescents. It is 
      the active ingredient found in cough medicine which is used for suppressing 
      cough. High dosage of DXM can induce euphoria, dissociative effects and even 
      hallucinations. Chronic use of DXM may also lead to depressive-related symptoms. 
      Lycium barbarum, commonly known as wolfberry, has been used as a traditional 
      Chinese medicine for the treatment of ageing-related neurodegenerative diseases. 
      A recent study has shown the potential beneficial effect of Lycium barbarum to 
      reduce depression-like behavior. In the present study, we investigated the role 
      of Lycium barbarum polysaccharide (LBP) to alleviate DXM-induced emotional 
      distress. Sprague Dawley rats were divided into 4 groups (n=6 per group), 
      including the normal control (vehicles only), DXM-treated group (40 mg/kg DXM), 
      LBP-treated group (1 mg/kg LBP) and DXM+ LBP-treated group (40 mg/kg DXM and 1 
      mg/kg LBP). After two-week treatment, the DXM-treated group showed increased 
      depression-like and social anxiety-like behaviors in the forced swim test and 
      social interaction test respectively. On the other hand, the adverse behavioral 
      effects induced by DXM were reduced by LBP treatment. Histological results showed 
      that LBP treatment alone did not promote hippocampal neurogenesis when compared 
      to the normal control, but LBP could lessen the suppression of hippocampal 
      neurogenesis induced by DXM. The findings provide insights for the potential use 
      of wolfberry as an adjunct treatment option for alleviating mood disturbances 
      during rehabilitation of cough syrup abusers.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Po, Kevin Kai-Ting
AU  - Po KK
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong 
      Kong.
FAU - Leung, Joseph Wai-Hin
AU  - Leung JW
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong 
      Kong.
FAU - Chan, Jackie Ngai-Man
AU  - Chan JN
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong 
      Kong.
FAU - Fung, Timothy Kai-Hang
AU  - Fung TK
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong 
      Kong.
FAU - Sanchez-Vidana, Dalinda Isabel
AU  - Sanchez-Vidana DI
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong 
      Kong.
FAU - Sin, Emily Lok-Lam
AU  - Sin EL
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong 
      Kong.
FAU - So, Kwok-Fai
AU  - So KF
AD  - Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong 
      Kong, Hong Kong; State Key Laboratory of Brain and Cognitive Science, The 
      University of Hong Kong, Hong Kong; GHM Institute of CNS Regeneration, Jinan 
      University, Guangzhou, China; Co-innovation Center of Neuroregeneration, Nantong 
      University, Jiangsu, PR China; Ministry of Education CNS Regeneration 
      International Collaborative Joint Laboratory, Jinan University, Guangzhou, China.
FAU - Lau, Benson Wui-Man
AU  - Lau BW
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong 
      Kong. Electronic address: benson.lau@polyu.edu.hk.
FAU - Siu, Andrew Man-Hong
AU  - Siu AM
AD  - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong 
      Kong.
LA  - eng
PT  - Journal Article
DEP - 20170621
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Antitussive Agents)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Psychotropic Drugs)
RN  - 0 (lycium barbarum polysaccharide)
RN  - 7355X3ROTS (Dextromethorphan)
SB  - IM
MH  - Animals
MH  - Antitussive Agents/toxicity
MH  - Anxiety Disorders/chemically induced/*drug therapy/pathology/physiopathology
MH  - Depressive Disorder/chemically induced/*drug therapy/pathology/physiopathology
MH  - Dextromethorphan/*toxicity
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Hippocampus/drug effects/pathology/physiopathology
MH  - Male
MH  - Neurogenesis/drug effects
MH  - Neurons/drug effects/pathology/physiology
MH  - Neuroprotective Agents/*pharmacology
MH  - Psychotropic Drugs/pharmacology
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Social Behavior
MH  - Substance-Related Disorders/*drug therapy/pathology/physiopathology
OTO - NOTNLM
OT  - Cough syrup abuse
OT  - Dextromethorphan
OT  - Lycium barbarum
OT  - Neurogenesis
EDAT- 2017/06/25 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/06/25 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/06/12 00:00 [revised]
PHST- 2017/06/20 00:00 [accepted]
PHST- 2017/06/25 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/06/25 06:00 [entrez]
AID - S0361-9230(17)30144-2 [pii]
AID - 10.1016/j.brainresbull.2017.06.014 [doi]
PST - ppublish
SO  - Brain Res Bull. 2017 Sep;134:10-17. doi: 10.1016/j.brainresbull.2017.06.014. Epub 
      2017 Jun 21.