PMID- 28647666
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 221
DP  - 2017 Oct 15
TI  - Brain-derived neurotrophic factor levels and depression during methamphetamine 
      withdrawal.
PG  - 165-171
LID - S0165-0327(16)32172-3 [pii]
LID - 10.1016/j.jad.2017.06.017 [doi]
AB  - BACKGROUND: Depression symptoms is highly comorbid with methamphetamine (METH) 
      dependence. Except for the role in the pathophysiology of depression symptoms, 
      brain-derived neurotrophic factor (BDNF) is also involved in the METH dependence. 
      The present study aims to explore whether BDNF plays a role in the development of 
      depression symptoms during METH withdrawal. METHODS: We recruited 179 patients 
      with METH dependence who were followed up for two weeks. Ultimately, 131 (73.2%) 
      patients finished the follow-up. Besides, 90 healthy controls were also 
      recruited. Serum BDNF levels were measured by DuoSet ELISA Development System 
      upon admission. The short form (13 items) of the Beck Depression Inventory (BDI) 
      and Amphetamine Withdrawal Questionnaire (AWQ) were used to measure the 
      depression and withdrawal symptoms. Patients with BDI score >/= 8 were identified 
      to have depression symptoms. RESULTS: Of the 131 patients, 64 (48.9%) were 
      identified to have depression symptoms at the two-week endpoint. Patients with 
      depression symptoms showed significantly lower BDNF levels than those with no 
      depression symptoms. Serum BDNF levels (</= 1251.0pg/ml) were independently 
      associated with the development of depression symptoms during METH withdrawal (OR 
      = 3.50, 95% CI, 1.14-10.73, p = 0.028). LIMITATIONS: BDNF levels were tested in 
      serum but not in brain and the baseline BDI and AWQ scores between the depression 
      and non-depression groups were not matched. Besides, the follow-up time was 
      relatively short. CONCLUSIONS: Our study demonstrated that patients with serum 
      BDNF levels </= 1251.0pg/ml had higher risk of depression symptoms during METH 
      withdrawal.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Ren, Wenwei
AU  - Ren W
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Luan, Xiaoqian
AU  - Luan X
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200000, 
      China.
FAU - Gutteea, Priyanka
AU  - Gutteea P
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Cai, Yan
AU  - Cai Y
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Zhao, Jiyun
AU  - Zhao J
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Gu, Yingying
AU  - Gu Y
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Wu, Chaowen
AU  - Wu C
AD  - Department of Neurology, Ruian People's Hospital, Wenzhou 325000, China.
FAU - Su, Hang
AU  - Su H
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Tao, Jingyan
AU  - Tao J
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Xie, Ying
AU  - Xie Y
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Lv, Dezhao
AU  - Lv D
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China.
FAU - Feng, Liang
AU  - Feng L
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China. Electronic address: fengliangyw@126.com.
FAU - He, Jincai
AU  - He J
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou 325000, China. Electronic address: hjc@wmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170614
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Adult
MH  - Amphetamine-Related Disorders/blood/epidemiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Depression/*blood/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Methamphetamine
MH  - Risk Assessment
MH  - Substance Withdrawal Syndrome/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Addiction
OT  - Depression
OT  - Drug abuse
OT  - Mood disorders
OT  - Substance use disorders
EDAT- 2017/06/26 06:00
MHDA- 2018/02/23 06:00
CRDT- 2017/06/26 06:00
PHST- 2016/11/20 00:00 [received]
PHST- 2017/04/23 00:00 [revised]
PHST- 2017/06/11 00:00 [accepted]
PHST- 2017/06/26 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
PHST- 2017/06/26 06:00 [entrez]
AID - S0165-0327(16)32172-3 [pii]
AID - 10.1016/j.jad.2017.06.017 [doi]
PST - ppublish
SO  - J Affect Disord. 2017 Oct 15;221:165-171. doi: 10.1016/j.jad.2017.06.017. Epub 
      2017 Jun 14.