PMID- 28648204
OWN - NLM
STAT- MEDLINE
DCOM- 20180524
LR  - 20180524
IS  - 1989-2284 (Electronic)
IS  - 0211-6995 (Linking)
VI  - 37
IP  - 3
DP  - 2017 May-Jun
TI  - Long-term prognosis of chronic kidney disease in non-ST elevation acute coronary 
      syndrome treated with invasive strategy.
PG  - 276-284
LID - S0211-6995(16)30206-5 [pii]
LID - 10.1016/j.nefro.2016.11.011 [doi]
AB  - BACKGROUND AND AIM: Patients with chronic kidney disease (CKD) have an increased 
      risk of adverse cardiovascular outcomes after non-ST elevation acute coronary 
      syndrome (NSTEACS). However, the information available on this specific 
      population, is scarce. We evaluate the impact of CKD on long-term prognosis in 
      patients with NSTEACS managed with invasive strategy. METHODS: We conduct a 
      prospective registry of patients with NSTEACS and coronary angiography. CKD was 
      defined as a glomerular filtration rate < 60ml/min/1,73m(2). The composite 
      primary end-point was cardiac death and non fatal cardiovascular readmission. We 
      estimated the cumulative probability and hazard rate (HR) of combined primary 
      end-point at 3-years according to the presence or absence of CKD. RESULTS: We 
      included 248 p with mean age of 66.9 years, 25% women. CKD was present at 
      baseline in 67 patients (27%). Patients with CKD were older (74.9 vs. 63.9 years; 
      P<.0001) with more prevalence of hypertension (89.6 vs. 66.3%; P<.0001), diabetes 
      (53.7 vs. 35.9%; P=.011), history of heart failure (13.4 vs. 3.9%; P=.006) and 
      anemia (47.8 vs. 16%; P<.0001). No differences in the extent of coronary artery 
      disease. CKD was associated with higher cumulative probability (49.3 vs. 28.2%; 
      log-rank P=.001) and HR of the primary combined end-point (HR: 1.94; CI95%: 
      1.12-3.27; P=.012). CKD was an independent predictor of adverse cardiovascular 
      outcomes at 3-years (HR: 1.66; CI95%: 1.05-2.61; P=.03). CONCLUSIONS: In NSTEACS 
      patients treated with invasive strategie CKD is associated independently with an 
      increased risk of adverse cardiovascular outcomes at 3years.
CI  - Copyright (c) 2016 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, 
      S.L.U. All rights reserved.
FAU - Roldan Torres, Ildefonso
AU  - Roldan Torres I
AD  - Servicio de Cardiologia, Hospital Universitario Dr. Peset, Valencia, Espana. 
      Electronic address: il.roldant@comv.es.
FAU - Salvador Mercader, Inmaculada
AU  - Salvador Mercader I
AD  - Servicio de Cardiologia, Hospital Universitario Dr. Peset, Valencia, Espana.
FAU - Cabades Rumbeu, Claudia
AU  - Cabades Rumbeu C
AD  - Servicio de Cardiologia, Hospital Universitario Dr. Peset, Valencia, Espana.
FAU - Diez Gil, Jose Luis
AU  - Diez Gil JL
AD  - Servicio de Cardiologia, Hospital Universitario Dr. Peset, Valencia, Espana.
FAU - Ferrando Cervello, Jose
AU  - Ferrando Cervello J
AD  - Servicio de Cardiologia, Hospital Universitario Dr. Peset, Valencia, Espana.
FAU - Monteagudo Viana, Marta
AU  - Monteagudo Viana M
AD  - Servicio de Cardiologia, Hospital Universitario Dr. Peset, Valencia, Espana.
FAU - Fernandez Galera, Ruben
AU  - Fernandez Galera R
AD  - Servicio de Cardiologia, Hospital Universitario Dr. Peset, Valencia, Espana.
FAU - Mora Llabata, Vicente
AU  - Mora Llabata V
AD  - Servicio de Cardiologia, Hospital Universitario Dr. Peset, Valencia, Espana.
LA  - eng
LA  - spa
PT  - Journal Article
TT  - Pronostico a largo plazo de la enfermedad renal cronica en el sindrome coronario 
      agudo sin elevacion del segmento ST tratado con estrategia invasiva.
PL  - Spain
TA  - Nefrologia
JT  - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
JID - 8301215
SB  - IM
MH  - Acute Coronary Syndrome/epidemiology/*etiology/*surgery
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Non-ST Elevated Myocardial Infarction/epidemiology/*etiology/*surgery
MH  - Prognosis
MH  - Prospective Studies
MH  - Renal Insufficiency, Chronic/*complications
MH  - Time Factors
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Chronic kidney disease
OT  - Enfermedad renal cronica
OT  - Estrategia invasiva
OT  - Invasive management
OT  - Prognosis
OT  - Pronostico
OT  - Sindrome coronario agudo
EDAT- 2017/06/27 06:00
MHDA- 2018/05/25 06:00
CRDT- 2017/06/27 06:00
PHST- 2016/09/15 00:00 [received]
PHST- 2016/10/25 00:00 [revised]
PHST- 2016/11/17 00:00 [accepted]
PHST- 2017/06/27 06:00 [entrez]
PHST- 2017/06/27 06:00 [pubmed]
PHST- 2018/05/25 06:00 [medline]
AID - S0211-6995(16)30206-5 [pii]
AID - 10.1016/j.nefro.2016.11.011 [doi]
PST - ppublish
SO  - Nefrologia. 2017 May-Jun;37(3):276-284. doi: 10.1016/j.nefro.2016.11.011.