PMID- 28648555
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20191210
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 31
IP  - 9
DP  - 2017 Sep
TI  - Comparison of plasma pigment epithelium-derived factor (PEDF), retinol binding 
      protein 4 (RBP-4), chitinase-3-like protein 1 (YKL-40) and brain-derived 
      neurotrophic factor (BDNF) for the identification of insulin resistance.
PG  - 1423-1429
LID - S1056-8727(17)30611-6 [pii]
LID - 10.1016/j.jdiacomp.2017.06.002 [doi]
AB  - AIMS: To evaluate and compare the association of four potential insulin 
      resistance (IR) biomarkers (pigment-epithelium-derived factor [PEDF], 
      retinol-binding-protein-4 [RBP-4], chitinase-3-like protein 1 [YKL-40] and 
      brain-derived neurotrophic factor [BDNF]) with objective measures of IR. METHODS: 
      We studied 81 subjects with different metabolic profiles. All participants 
      underwent a 5-point OGTT with calculation of multiple IR indexes. A subgroup of 
      21 participants additionally underwent a hyperinsulinemic-euglycemic clamp. IR 
      was defined as belonging to the highest quartile of incremental area under the 
      insulin curve (iAUCins), or to the lowest quartile of the insulin sensitivity 
      index (ISI). RESULTS: PEDF was associated with adiposity variables. PEDF and RBP4 
      increased linearly across quartiles of iAUCins (for PEDF p-trend=0.029; for RBP-4 
      p-trend=0.053). YKL-40 and BDNF were not associated with any adiposity or IR 
      variable. PEDF and RBP-4 levels identified individuals with IR by the iAUCins 
      definition: A PEDF cutoff of 11.9ng/mL had 60% sensitivity and 68% specificity, 
      while a RBP-4 cutoff of 71.6ng/mL had 70% sensitivity and 57% specificity. In 
      multiple regression analyses simultaneously including clinical variables and the 
      studied biomarkers, only BMI, PEDF and RBP-4 remained significant predictors of 
      IR. CONCLUSIONS: Plasma PEDF and RBP4 identified IR in subjects with no prior 
      diagnosis of diabetes.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Toloza, F J K
AU  - Toloza FJK
AD  - Universidad de los Andes, School of Medicine, Bogota, Colombia.
FAU - Perez-Matos, M C
AU  - Perez-Matos MC
AD  - Universidad de los Andes, School of Medicine, Bogota, Colombia.
FAU - Ricardo-Silgado, M L
AU  - Ricardo-Silgado ML
AD  - Universidad de los Andes, School of Medicine, Bogota, Colombia.
FAU - Morales-Alvarez, M C
AU  - Morales-Alvarez MC
AD  - Universidad de los Andes, School of Medicine, Bogota, Colombia.
FAU - Mantilla-Rivas, J O
AU  - Mantilla-Rivas JO
AD  - Universidad de los Andes, School of Medicine, Bogota, Colombia.
FAU - Pinzon-Cortes, J A
AU  - Pinzon-Cortes JA
AD  - Universidad de los Andes, School of Medicine, Bogota, Colombia.
FAU - Perez-Mayorga, M
AU  - Perez-Mayorga M
AD  - Universidad Militar Nueva Granada, School of Medicine, Bogota, Colombia.
FAU - Arevalo-Garcia, M L
AU  - Arevalo-Garcia ML
AD  - Fundacion Santa Fe de Bogota, Section of Endocrinology, Bogota, Colombia.
FAU - Tolosa-Gonzalez, G
AU  - Tolosa-Gonzalez G
AD  - Fundacion Santa Fe de Bogota, Section of Endocrinology, Bogota, Colombia.
FAU - Mendivil, C O
AU  - Mendivil CO
AD  - Universidad de los Andes, School of Medicine, Bogota, Colombia; Fundacion Santa 
      Fe de Bogota, Section of Endocrinology, Bogota, Colombia. Electronic address: 
      cmendivi@uniandes.edu.co.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170609
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (CHI3L1 protein, human)
RN  - 0 (Chitinase-3-Like Protein 1)
RN  - 0 (Eye Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RBP4 protein, human)
RN  - 0 (Retinol-Binding Proteins, Plasma)
RN  - 0 (Serpins)
RN  - 0 (pigment epithelium-derived factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chitinase-3-Like Protein 1/*blood
MH  - *Diagnostic Techniques, Endocrine
MH  - Eye Proteins/*blood
MH  - Female
MH  - Glucose Clamp Technique
MH  - Glucose Intolerance/blood/complications/diagnosis
MH  - Glucose Tolerance Test
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factors/*blood
MH  - Obesity/blood/complications/metabolism
MH  - Prediabetic State/blood/complications/diagnosis
MH  - Retinol-Binding Proteins, Plasma/*analysis/metabolism
MH  - Serpins/*blood
OTO - NOTNLM
OT  - Adipokine
OT  - Adiposity
OT  - Biomarker
OT  - Insulin resistance
OT  - Obesity
EDAT- 2017/06/27 06:00
MHDA- 2018/05/22 06:00
CRDT- 2017/06/27 06:00
PHST- 2017/04/24 00:00 [received]
PHST- 2017/05/11 00:00 [revised]
PHST- 2017/06/04 00:00 [accepted]
PHST- 2017/06/27 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2017/06/27 06:00 [entrez]
AID - S1056-8727(17)30611-6 [pii]
AID - 10.1016/j.jdiacomp.2017.06.002 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2017 Sep;31(9):1423-1429. doi: 
      10.1016/j.jdiacomp.2017.06.002. Epub 2017 Jun 9.