PMID- 28651188
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20221207
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 263
DP  - 2017 Aug
TI  - Hyperhomocysteinaemia is an independent risk factor for peripheral arterial 
      disease in a Chinese Han population.
PG  - 205-210
LID - S0021-9150(17)30195-8 [pii]
LID - 10.1016/j.atherosclerosis.2017.05.006 [doi]
AB  - BACKGROUND AND AIMS: Hyperhomocysteineamia (HHcy) has long been suggested as a 
      risk factor for atherosclerosis. However, the association between HHcy and 
      peripheral arterial disease (PAD) is still controversial. There is a lack of 
      research on this topic in the Chinese population. This study aims to provide 
      further results. METHODS: 240 PAD patients and 240 control subjects were 
      evaluated for both serum total homocysteine levels and ankle brachial indexes 
      (ABIs). Multivariable logistic regression models were used to estimate the 
      association between HHcy and the risk of developing PAD. Interaction and 
      stratified analyses were conducted according to age, sex, smoking status, 
      drinking status, and histories of chronic disease. RESULTS: The multivariate 
      logistic regression analyses revealed that the risk of PAD was significantly 
      associated with serum homocysteine levels. The interaction analysis showed no 
      interactive role in the association between HHcy and PAD, indicating that 
      homocysteine was associated with PAD independently of classical vascular risk 
      factors. CONCLUSIONS: In conclusion, HHcy is an independent risk factor for PAD 
      in the Chinese Han population. A prospective and randomized clinical trial of 
      homocysteine lowering therapy in the Chinese population is needed to assess the 
      causal nature of the relationship.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Rong, Dan
AU  - Rong D
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Liu, Jie
AU  - Liu J
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China; Vascular Surgery Research Laboratories, Division of Vascular and 
      Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, MA, USA.
FAU - Jia, Xin
AU  - Jia X
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Al-Nafisee, Daniah
AU  - Al-Nafisee D
AD  - School of Medicine, The Royal College of Surgeons, Dublin, Ireland.
FAU - Jia, Senhao
AU  - Jia S
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Sun, Guoyi
AU  - Sun G
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Li, Yue
AU  - Li Y
AD  - Department of Cardiovascular Surgery, Chinese PLA Air Force General Hospital, 
      Beijing, China.
FAU - Lu, Weihang
AU  - Lu W
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Li, Haifeng
AU  - Li H
AD  - Department of Vascular and Endovascular Surgery, Shanxian Dongda Hospital, Heze, 
      Shandong, China.
FAU - Zhang, Hongpeng
AU  - Zhang H
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Ma, Xiaohui
AU  - Ma X
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Xiong, Jiang
AU  - Xiong J
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Liu, Xiaoping
AU  - Liu X
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China.
FAU - Khalil, Raouf A
AU  - Khalil RA
AD  - Vascular Surgery Research Laboratories, Division of Vascular and Endovascular 
      Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
FAU - Guo, Wei
AU  - Guo W
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing, China. Electronic address: guoweiplagh@sina.com.
LA  - eng
GR  - R01 HL065998/HL/NHLBI NIH HHS/United States
GR  - R21 HL111775/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20170505
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aged
MH  - Ankle Brachial Index
MH  - *Asian People
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - China/epidemiology
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/diagnosis/*ethnology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Peripheral Arterial Disease/diagnosis/*ethnology
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
PMC - PMC5557685
MID - NIHMS874765
OTO - NOTNLM
OT  - Case-control study
OT  - Homocysteine
OT  - Hyperhomocysteineamia
OT  - Peripheral arterial disease
COIS- Conflicts of interest There are no conflicts of interest associated with this 
      study.
EDAT- 2017/06/27 06:00
MHDA- 2018/05/08 06:00
PMCR- 2018/08/01
CRDT- 2017/06/27 06:00
PHST- 2017/01/16 00:00 [received]
PHST- 2017/04/18 00:00 [revised]
PHST- 2017/05/04 00:00 [accepted]
PHST- 2017/06/27 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/06/27 06:00 [entrez]
PHST- 2018/08/01 00:00 [pmc-release]
AID - S0021-9150(17)30195-8 [pii]
AID - 10.1016/j.atherosclerosis.2017.05.006 [doi]
PST - ppublish
SO  - Atherosclerosis. 2017 Aug;263:205-210. doi: 
      10.1016/j.atherosclerosis.2017.05.006. Epub 2017 May 5.