PMID- 28652579
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1476-5551 (Electronic)
IS  - 0887-6924 (Linking)
VI  - 32
IP  - 1
DP  - 2018 Jan
TI  - HLA-DPB1 mismatch induces a graft-versus-leukemia effect without severe acute 
      GVHD after single-unit umbilical cord blood transplantation.
PG  - 168-175
LID - 10.1038/leu.2017.202 [doi]
AB  - Although it is known that human leukocyte antigen (HLA)-DPB1 disparity has a 
      strong impact on outcomes in unrelated hematopoietic transplantation with 
      induction of acute graft-versus-host disease (GVHD) and a graft-versus-leukemia 
      (GVL) effect, its role in unrelated umbilical cord blood transplantation (UR-CBT) 
      has yet to be fully clarified. Our current study is being conducted to elucidate 
      the impact of HLA-DPB1 mismatch, along with the effect of other HLA loci 
      mismatches at the allele level. HLA six loci alleles were retrospectively typed 
      in 1157 Japanese donors and patients with leukemia or myelodysplastic syndrome 
      who underwent transplantation with a single unit of cord blood. HLA-DPB1 mismatch 
      was associated with a significant reduction in leukemia relapse (hazard ratio 
      0.61, P<0.001), whereas the other HLA loci allele-level mismatches did not. No 
      significant effect of HLA-DPB1 mismatch was observed in the risk of acute GVHD, 
      engraftment or mortality. This HLA-DPB1 GVL effect without induction of severe 
      acute GVHD or deterioration of survival rate has not been reported in unrelated 
      bone marrow or peripheral blood stem cell transplantations, suggesting apparent 
      advantages of UR-CBT. Accordingly, selection of an HLA-DPB1 mismatch cord blood 
      might be the preferable choice for single-unit UR-CBT.
FAU - Yabe, T
AU  - Yabe T
AD  - Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.
FAU - Azuma, F
AU  - Azuma F
AD  - Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.
FAU - Kashiwase, K
AU  - Kashiwase K
AD  - Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.
FAU - Matsumoto, K
AU  - Matsumoto K
AD  - Japanese Red Cross Kinki Cord Blood Bank, Osaka, Japan.
FAU - Orihara, T
AU  - Orihara T
AD  - Japanese Red Cross Hokkaido Cord Blood Bank, Sapporo, Japan.
FAU - Yabe, H
AU  - Yabe H
AD  - Tokai University Cord Blood Bank, Isehara, Japan.
FAU - Kato, S
AU  - Kato S
AD  - Tokai University Cord Blood Bank, Isehara, Japan.
FAU - Kato, K
AU  - Kato K
AD  - Central Japan Cord Blood Bank, Seto, Japan.
FAU - Kai, S
AU  - Kai S
AD  - Hyogo Cord Blood Bank Nishinomiya, Japan.
FAU - Mori, T
AU  - Mori T
AD  - Japanese Red Cross Kyushu Cord Blood Bank, Chikushino, Japan.
FAU - Morishima, S
AU  - Morishima S
AD  - Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology 
      (Second Department of Internal Medicine), Graduate School of Medicine, University 
      of the Ryukyus, Nishihara, Japan.
FAU - Satake, M
AU  - Satake M
AD  - Japanese Red Cross Blood Service Headquarters, Tokyo, Japan.
FAU - Takanashi, M
AU  - Takanashi M
AD  - Japanese Red Cross Blood Service Headquarters, Tokyo, Japan.
FAU - Nakajima, K
AU  - Nakajima K
AD  - Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.
AD  - Japanese Red Cross Kanto-Koshinetsu Cord Blood Bank, Tokyo, Japan.
FAU - Morishima, Y
AU  - Morishima Y
AD  - Central Japan Cord Blood Bank, Seto, Japan.
AD  - Aichi Cancer Center Research Institute, Nagoya, Japan.
CN  - Japanese Cord Blood Transplantation Histocompatibility Research Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170627
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Bone Marrow Transplantation/methods
MH  - Child
MH  - Child, Preschool
MH  - Cord Blood Stem Cell Transplantation/methods
MH  - Female
MH  - Graft vs Host Disease/*immunology
MH  - Graft vs Leukemia Effect/*immunology
MH  - HLA-DP beta-Chains/*immunology
MH  - Hematopoietic Stem Cell Transplantation/methods
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Leukemia/*immunology
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/immunology
MH  - Peripheral Blood Stem Cell Transplantation/methods
MH  - Transplantation, Homologous/methods
MH  - Unrelated Donors
MH  - Young Adult
EDAT- 2017/06/28 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/06/28 06:00
PHST- 2017/02/15 00:00 [received]
PHST- 2017/05/26 00:00 [revised]
PHST- 2017/06/01 00:00 [accepted]
PHST- 2017/06/28 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/06/28 06:00 [entrez]
AID - leu2017202 [pii]
AID - 10.1038/leu.2017.202 [doi]
PST - ppublish
SO  - Leukemia. 2018 Jan;32(1):168-175. doi: 10.1038/leu.2017.202. Epub 2017 Jun 27.