PMID- 28653113
OWN - NLM
STAT- MEDLINE
DCOM- 20190729
LR  - 20190729
IS  - 1615-6692 (Electronic)
IS  - 0340-9937 (Linking)
VI  - 43
IP  - 5
DP  - 2018 Aug
TI  - Association of soluble ST2 with functional capacity in outpatients with heart 
      failure.
PG  - 455-460
LID - 10.1007/s00059-017-4590-1 [doi]
AB  - BACKGROUND: Biomarkers play an important role in the risk stratification of 
      patients with heart failure (HF). Recent studies have shown that soluble 
      suppression of tumorigenicity 2 (sST2), a member of the interleukin 1 receptor 
      family, is associated with disease prognosis in acute and chronic HF. In this 
      study we aimed to investigate the relation between sST2 level and functional 
      capacity in outpatients with systolic HF. PATIENTS AND METHODS: This study 
      included 120 HF patients with reduced ejection fraction (HFrEF; EF </= 40%). The 
      mean age of patients was 66 +/- 11 years. Advanced HF (New York Heart Association 
      [NYHA] functional class III-IV) was observed in 35 patients (29%). RESULTS: 
      sST2 levels were on average higher in patients with NYHA functional classes III 
      and IV than in patients with NYHA functional classes I and II (51 [9-198] vs. 
      25 ng/ml [9-118], p < 0.001). In a multiple logistic regression model, sST2 level 
      (OR: 1.044, p = 0.004, 95% CI: 1.014-1.075), hemoglobin level (OR: 0.590, p = 
      0.001, 95% CI: 0.433-0.805), total cholesterol level (OR: 0.977, p = 0.004, 95% 
      CI: 0.962-0.993), and age (OR: 1.066, p = 0.047, 95% CI: 1.001-1.136) were 
      associated with poor functional capacity. In receiver operating characteristic 
      (ROC) curve analysis, the optimal cut-off value of sST2 for predicting poor 
      functional capacity was >42 ng/ml, with 63% sensitivity and 88% specificity (AUC: 
      0.810, 95% CI: 0.728- 0.875). CONCLUSION: Higher sST2 levels were strongly 
      associated with poor NYHA functional class, independent of cardiac risk factors, 
      in outpatients with HFrEF.
FAU - Yucel, O
AU  - Yucel O
AD  - Departments of Cardiology, Samsun Education and Research Hospital, Samsun, 
      Turkey.
FAU - Gul, I
AU  - Gul I
AD  - Departments of Cardiology, Cumhuriyet University Medical School, Sivas, Turkey.
FAU - Zararsiz, A
AU  - Zararsiz A
AD  - Departments of Cardiology, Cumhuriyet University Medical School, Sivas, Turkey.
FAU - Demirpence, O
AU  - Demirpence O
AD  - Departments of Biochemistry, Cumhuriyet University Medical School, Sivas, Turkey.
FAU - Yucel, H
AU  - Yucel H
AD  - Departments of Cardiology, Cumhuriyet University Medical School, Sivas, Turkey.
FAU - Cinar, Z
AU  - Cinar Z
AD  - Departments of Biostatistics, Cumhuriyet University Medical School, Sivas, 
      Turkey.
FAU - Zorlu, A
AU  - Zorlu A
AD  - Departments of Cardiology, Cumhuriyet University Medical School, Sivas, Turkey. 
      dralizorlu@gmail.com.
FAU - Yilmaz, M B
AU  - Yilmaz MB
AD  - Departments of Cardiology, Cumhuriyet University Medical School, Sivas, Turkey.
LA  - eng
PT  - Journal Article
TT  - Zusammenhang zwischen loslichem ST2 und funktioneller Kapazitat bei ambulant 
      versorgten Herzinsuffizienzpatienten.
DEP - 20170626
PL  - Germany
TA  - Herz
JT  - Herz
JID - 7801231
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-1 Receptor-Like 1 Protein)
MH  - Aged
MH  - *Biomarkers/blood
MH  - Female
MH  - *Heart Failure/blood/diagnosis
MH  - Humans
MH  - Interleukin-1 Receptor-Like 1 Protein
MH  - Male
MH  - Middle Aged
MH  - Outpatients
MH  - Prognosis
MH  - Stroke Volume
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Biomarkers
OT  - Exercise tolerance
OT  - Hospitalization
OT  - Outpatients
OT  - Systolic heart failure
EDAT- 2017/06/28 06:00
MHDA- 2019/07/30 06:00
CRDT- 2017/06/28 06:00
PHST- 2017/02/13 00:00 [received]
PHST- 2017/06/05 00:00 [accepted]
PHST- 2017/05/23 00:00 [revised]
PHST- 2017/06/28 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2017/06/28 06:00 [entrez]
AID - 10.1007/s00059-017-4590-1 [pii]
AID - 10.1007/s00059-017-4590-1 [doi]
PST - ppublish
SO  - Herz. 2018 Aug;43(5):455-460. doi: 10.1007/s00059-017-4590-1. Epub 2017 Jun 26.