PMID- 28653180
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20181113
IS  - 1619-7089 (Electronic)
IS  - 1619-7070 (Linking)
VI  - 44
IP  - 11
DP  - 2017 Oct
TI  - Regional interaction between myocardial sympathetic denervation, contractile 
      dysfunction, and fibrosis in heart failure with preserved ejection fraction: 
      (11)C-hydroxyephedrine PET study.
PG  - 1897-1905
LID - 10.1007/s00259-017-3760-y [doi]
AB  - PURPOSE: This investigation aimed to identify significant predictors of regional 
      sympathetic denervation quantified by (11)C-hydroxyephedrine (HED) positron 
      emission tomography (PET) in patients with heart failure with preserved left 
      ventricular ejection fraction (HFpEF). METHODS: Included in the study were 34 
      patients (age 63 +/- 15 years, 23 men) with HFpEF (left ventricular ejection 
      fraction >/=40%) and 11 age-matched volunteers without heart failure. Cardiac 
      magnetic resonance imaging was performed to measure left ventricular size and 
      function, and the extent of myocardial late gadolinium enhancement (LGE). 
      (11)C-HED PET was performed to quantify myocardial sympathetic innervation that 
      was expressed as a (11)C-HED retention index (RI, %/min). To identify predictors 
      of regional (11)C-HED RI in HFpEF patients, we propose a multivariate 
      mixed-effects model for repeated measures over segments with an unstructured 
      covariance matrix. RESULTS: Global (11)C-HED RI was significantly lower and more 
      heterogeneous in HFpEF patients than in volunteers (P < 0.01 for all). Regional 
      (11)C-HED RI was correlated positively with systolic wall thickening (r = 0.42, 
      P < 0.001) and negatively with the extent of LGE (r = -0.43, P < 0.001). Segments 
      in HFpEF patients with a large extent of LGE had the lowest regional (11)C-HED RI 
      among all segments (P < 0.001 in post hoc tests). Multivariate analysis 
      demonstrated that systolic wall thickening and the extent of LGE were significant 
      predictors of regional (11)C-HED RI in HFpEF patients (both P </= 0.001). 
      CONCLUSION: Regional sympathetic denervation was associated with contractile 
      dysfunction and fibrotic burden in HFpEF patients, suggesting that regional 
      sympathetic denervation may provide an integrated measure of myocardial damage in 
      HFpEF.
FAU - Aikawa, Tadao
AU  - Aikawa T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, 
      Japan.
FAU - Naya, Masanao
AU  - Naya M
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, 
      Japan. naya@med.hokudai.ac.jp.
FAU - Obara, Masahiko
AU  - Obara M
AD  - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, 
      Japan.
FAU - Oyama-Manabe, Noriko
AU  - Oyama-Manabe N
AD  - Department of Diagnostic and Interventional Radiology, Hokkaido University 
      Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, 060-8648, Japan.
FAU - Manabe, Osamu
AU  - Manabe O
AD  - Department of Nuclear Medicine, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, 
      Japan.
FAU - Magota, Keiichi
AU  - Magota K
AD  - Division of Medical Imaging and Technology, Hokkaido University Hospital, 
      Kita-14, Nishi-5, Kita-ku, Sapporo, 060-8648, Japan.
FAU - Ito, Yoichi M
AU  - Ito YM
AD  - Department of Biostatistics, Faculty of Medicine and Graduate School of Medicine, 
      Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.
FAU - Katoh, Chietsugu
AU  - Katoh C
AD  - Department of Biomedical Science and Engineering, Faculty of Health Sciences, 
      Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.
FAU - Tamaki, Nagara
AU  - Tamaki N
AD  - Department of Radiology, Kyoto Prefectural University of Medicine, Kajii-cho, 
      Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
LA  - eng
GR  - JP24591742/Ministry of Education, Culture, Sports, Science, and Technology/
PT  - Journal Article
DEP - 20170626
PL  - Germany
TA  - Eur J Nucl Med Mol Imaging
JT  - European journal of nuclear medicine and molecular imaging
JID - 101140988
RN  - 0 (Radiopharmaceuticals)
RN  - 3002-40-2 (3-hydroxyephedrine)
RN  - GN83C131XS (Ephedrine)
SB  - IM
MH  - Aged
MH  - Ephedrine/*analogs & derivatives
MH  - Female
MH  - Fibrosis
MH  - Heart Failure/*diagnostic imaging/pathology/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Contraction
MH  - *Positron-Emission Tomography
MH  - *Radiopharmaceuticals
MH  - Stroke Volume
MH  - Sympathetic Nervous System/diagnostic imaging/*physiopathology
OTO - NOTNLM
OT  - 11C-Hydroxyephedrine
OT  - Contractile dysfunction
OT  - Heart failure with preserved ejection fraction
OT  - Myocardial fibrosis
OT  - Regional sympathetic denervation
EDAT- 2017/06/28 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/06/28 06:00
PHST- 2017/04/18 00:00 [received]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2017/06/28 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
PHST- 2017/06/28 06:00 [entrez]
AID - 10.1007/s00259-017-3760-y [pii]
AID - 10.1007/s00259-017-3760-y [doi]
PST - ppublish
SO  - Eur J Nucl Med Mol Imaging. 2017 Oct;44(11):1897-1905. doi: 
      10.1007/s00259-017-3760-y. Epub 2017 Jun 26.