PMID- 28653198
OWN - NLM
STAT- MEDLINE
DCOM- 20181011
LR  - 20181113
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 24
IP  - 23
DP  - 2017 Aug
TI  - A combined NMR- and HPLC-MS/MS-based metabolomics to evaluate the metabolic 
      perturbations and subacute toxic effects of endosulfan on mice.
PG  - 18870-18880
LID - 10.1007/s11356-017-9534-z [doi]
AB  - Endosulfan is the newly persistent organic pollutants (POPs) added to the 
      Stockholm Convention as its widespread use, persistence, bioaccumulation, 
      long-range transport, endocrine disruption, and toxicity related to various 
      adverse effects. In the present study, male mice were administrated endosulfan at 
      0, 0.5, and 3.5 mg/kg by gavage for 2 weeks. (1)H-NMR-based urinary metabolomics, 
      HPLC-MS/MS-based targeted serum metabolomics, clinical analysis, and 
      histopathology techniques were employed to evaluate the metabolic perturbations 
      of subacute endosulfan exposure. Endosulfan exposures resulted in weight loss, 
      liver inflammation and necrosis, and alterations in serum amino acids and urine 
      metabolomics. Based on altered metabolites, several significantly perturbed 
      pathways were identified including glycine, serine, and threonine metabolism; TCA 
      cycle; pyruvate metabolism; glycolysis or gluconeogenesis; glycerophospholipid 
      metabolism; and glyoxylate and dicarboxylate metabolism. Such pathways were 
      highly related to amino acid metabolism, energy metabolism, and lipid metabolism. 
      In addition, metabolomic results also demonstrated that gut microbiota was 
      remarkably altered after endosulfan exposure. These observations may provide 
      novel insight into revealing the potential toxic mechanism and evaluating the 
      health risk of endosulfan exposure at metabolomic level.
FAU - Zhang, Ping
AU  - Zhang P
AD  - Key Laboratory of Entomology and Pest Control Engineering, College of Plant 
      Protection, Southwest University, Chongqing, 400715, China.
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, China Agricultural University, Beijing, China.
FAU - Zhu, Wentao
AU  - Zhu W
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, China Agricultural University, Beijing, China.
FAU - Wang, Dezhen
AU  - Wang D
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, China Agricultural University, Beijing, China.
FAU - Yan, Jin
AU  - Yan J
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, China Agricultural University, Beijing, China.
FAU - Wang, Yao
AU  - Wang Y
AD  - Key Laboratory of Entomology and Pest Control Engineering, College of Plant 
      Protection, Southwest University, Chongqing, 400715, China.
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, China Agricultural University, Beijing, China.
FAU - Zhou, Zhiqiang
AU  - Zhou Z
AD  - Beijing Advanced Innovation Center for Food Nutrition and Human Health, 
      Department of Applied Chemistry, China Agricultural University, Beijing, China.
FAU - He, Lin
AU  - He L
AD  - Key Laboratory of Entomology and Pest Control Engineering, College of Plant 
      Protection, Southwest University, Chongqing, 400715, China. helinok@vip.tom.com.
LA  - eng
GR  - 21207158/National Natural Science Foundation of China/
GR  - 21337005/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20170626
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Insecticides)
RN  - OKA6A6ZD4K (Endosulfan)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Endosulfan/*toxicity
MH  - Gastrointestinal Microbiome
MH  - Insecticides/*toxicity
MH  - Male
MH  - Metabolic Networks and Pathways/drug effects
MH  - Metabolomics/*methods
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Proton Magnetic Resonance Spectroscopy/*methods
MH  - Tandem Mass Spectrometry/*methods
MH  - Toxicity Tests/*methods
OTO - NOTNLM
OT  - 1H-NMR
OT  - Amino acids
OT  - Endosulfan
OT  - HPLC-MS/MS
OT  - Metabolic perturbation
OT  - Metabolomics
EDAT- 2017/06/28 06:00
MHDA- 2018/10/12 06:00
CRDT- 2017/06/28 06:00
PHST- 2016/10/06 00:00 [received]
PHST- 2017/06/13 00:00 [accepted]
PHST- 2017/06/28 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2017/06/28 06:00 [entrez]
AID - 10.1007/s11356-017-9534-z [pii]
AID - 10.1007/s11356-017-9534-z [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2017 Aug;24(23):18870-18880. doi: 
      10.1007/s11356-017-9534-z. Epub 2017 Jun 26.