PMID- 28653491
OWN - NLM
STAT- MEDLINE
DCOM- 20180409
LR  - 20180627
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 78
IP  - 2
DP  - 2017 Aug
TI  - The role of gammadelta-T cells during human pregnancy.
LID - 10.1111/aji.12713 [doi]
AB  - Pregnancy is an evolutionarily important and mysterious process. The placenta, as 
      the nutrient and gas exchange organ, plays an essential role during this process. 
      In addition, the interaction between trophoblast and maternal immune cells at the 
      maternal-fetal interface is also associated with successful pregnancy. Human 
      leukocyte antigen (HLA) molecules on trophoblast cells are involved in protecting 
      the fetus from maternal rejection. Trophoblast cells comprise three 
      subpopulations, including syncytiotrophoblast cells, cytotrophoblast cells, and 
      extravillous trophoblast cells, and these cells express different HLA molecules. 
      Syncytiotrophoblast and extravillous trophoblast cells encounter maternal immune 
      cells from different sources, such as blood or decidua. The increased gammadelta-T cells 
      during human normal pregnancy indicate that these cells may play a role in this 
      process. In peripheral blood, Vgamma9Vdelta2-T cells display cytotoxicity through the 
      recognition of phosphoantigens derived from pathogens. However, HLA-E molecules 
      protect the trophoblast cells from the cytotoxicity of Vgamma9Vdelta2-T cells through 
      binding to the inhibitory receptor, CD94/NKG2A. In decidua, the main Vdelta1-T cells 
      maintain the pregnancy through the secretion of cytokines. In addition, the 
      imbalance between Vgamma9Vdelta2-T and Vdelta1-T cells, and the abnormal expression of the 
      receptors on gammadelta-T cells were observed in adverse pregnancy.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Huang, Chunyu
AU  - Huang C
AD  - Department of Paediatric and Adolescent Medicine, Li Ka Shing Faculty of 
      Medicine, the University of Hong Kong, HongKong, China.
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Urology of Hospital, Shenzhen, Guangdong, China.
FAU - Zeng, Yong
AU  - Zeng Y
AUID- ORCID: 0000-0002-6264-283X
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Urology of Hospital, Shenzhen, Guangdong, China.
FAU - Tu, Wenwei
AU  - Tu W
AD  - Department of Paediatric and Adolescent Medicine, Li Ka Shing Faculty of 
      Medicine, the University of Hong Kong, HongKong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170627
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Female
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Intraepithelial Lymphocytes/*immunology
MH  - Pregnancy/*immunology
MH  - Trophoblasts/immunology
OTO - NOTNLM
OT  - cytokine
OT  - human leukocyte antigen
OT  - killer inhibitory receptor
OT  - trophoblast
OT  - gammadelta-T cells
EDAT- 2017/06/28 06:00
MHDA- 2018/04/10 06:00
CRDT- 2017/06/28 06:00
PHST- 2017/02/24 00:00 [received]
PHST- 2017/05/04 00:00 [accepted]
PHST- 2017/06/28 06:00 [pubmed]
PHST- 2018/04/10 06:00 [medline]
PHST- 2017/06/28 06:00 [entrez]
AID - 10.1111/aji.12713 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2017 Aug;78(2). doi: 10.1111/aji.12713. Epub 2017 Jun 27.