PMID- 28653799
OWN - NLM
STAT- MEDLINE
DCOM- 20180306
LR  - 20211118
IS  - 1399-5618 (Electronic)
IS  - 1398-5647 (Print)
IS  - 1398-5647 (Linking)
VI  - 19
IP  - 4
DP  - 2017 Jun
TI  - Longitudinal cognitive trajectories and associated clinical variables in youth 
      with bipolar disorder.
PG  - 273-284
LID - 10.1111/bdi.12510 [doi]
AB  - OBJECTIVE: There is substantial interest in delineating the course of cognitive 
      functioning in bipolar (BP) youth. However, there are no longitudinal studies 
      aimed at defining subgroups of BP youth based on their distinctive cognitive 
      trajectories and their associated clinical variables. METHOD: Cognitive 
      functioning was measured in 135 participants from the Course and Outcome of BP 
      Youth (COBY) study using several subtests of the Cambridge Neuropsychological 
      Test Automated Battery (CANTAB). Youth were prospectively evaluated three times 
      on average every 13.75 months over 2.5 years. Clinical and functional outcomes 
      were assessed using the Longitudinal Interval Follow-Up Evaluation (LIFE). 
      RESULTS: Latent class growth analysis identified three longitudinal patterns of 
      cognitive functioning based on a general cognitive index: class 1, "persistently 
      high" (N=21; 15.6%); class 2, "persistently moderate" (N=82; 60.74%); and class 
      3, "persistently low" (N=32; 23.7%). All classes showed normal cognitive 
      functioning when compared with the CANTAB normative data. After adjustment for 
      confounders, youth from class 3 had a significantly greater percentage of time 
      with overall, manic, and depressive syndromal symptoms than youth in the other 
      two classes. Also, after adjustment for confounders, youth from class 3 had 
      significantly poorer global, academic, and social functioning than youth from 
      class 1. CONCLUSIONS: BP youth showed normal overall cognitive functioning that 
      remained stable during the follow-up within each class. However, 24% of BP youth 
      showed poorer cognitive functioning than the other BP youth. This subgroup had 
      poorer mood course and functioning, and may benefit from cognitive remediation 
      and early management with evidence-based pharmacological treatments.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Frias, Alvaro
AU  - Frias A
AUID- ORCID: 0000-0002-7123-3819
AD  - Adult Outpatient Mental Health Center, Consorci Sanitari del Maresme, Mataro, 
      Spain.
AD  - Western Psychiatric Institute and Clinic, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA, USA.
FAU - Dickstein, Daniel P
AU  - Dickstein DP
AD  - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown 
      University, Providence, RI, USA.
FAU - Merranko, John
AU  - Merranko J
AD  - Western Psychiatric Institute and Clinic, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA, USA.
FAU - Gill, Mary Kay
AU  - Gill MK
AD  - Western Psychiatric Institute and Clinic, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA, USA.
FAU - Goldstein, Tina R
AU  - Goldstein TR
AD  - Western Psychiatric Institute and Clinic, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA, USA.
FAU - Goldstein, Benjamin I
AU  - Goldstein BI
AUID- ORCID: 0000-0003-0340-349X
AD  - Department of Psychiatry, Sunnybrook Health Sciences Centre, University of 
      Toronto Faculty of Medicine, Toronto, ON, Canada.
FAU - Hower, Heather
AU  - Hower H
AD  - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown 
      University, Providence, RI, USA.
FAU - Yen, Shirley
AU  - Yen S
AD  - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown 
      University, Providence, RI, USA.
FAU - Hafeman, Danella M
AU  - Hafeman DM
AD  - Western Psychiatric Institute and Clinic, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA, USA.
FAU - Liao, Fangzi
AU  - Liao F
AD  - Western Psychiatric Institute and Clinic, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA, USA.
FAU - Diler, Rasim
AU  - Diler R
AUID- ORCID: 0000-0001-5895-6572
AD  - Western Psychiatric Institute and Clinic, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA, USA.
FAU - Axelson, David
AU  - Axelson D
AD  - Department of Psychiatry, Nationwide Children's Hospital and The Ohio State 
      College of Medicine, Columbus, OH, USA.
FAU - Strober, Michael
AU  - Strober M
AD  - Department of Psychiatry and Biobehavioral Sciences, David Geffen School of 
      Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
FAU - Hunt, Jeffrey I
AU  - Hunt JI
AD  - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown 
      University, Providence, RI, USA.
FAU - Ryan, Neal D
AU  - Ryan ND
AD  - Western Psychiatric Institute and Clinic, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA, USA.
FAU - Keller, Martin B
AU  - Keller MB
AD  - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown 
      University, Providence, RI, USA.
FAU - Birmaher, Boris
AU  - Birmaher B
AD  - Western Psychiatric Institute and Clinic, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA, USA.
LA  - eng
GR  - R01 MH059691/MH/NIMH NIH HHS/United States
GR  - R01 MH059929/MH/NIMH NIH HHS/United States
GR  - R01 MH059977/MH/NIMH NIH HHS/United States
GR  - R01 MH112543/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20170627
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
SB  - IM
MH  - Adolescent
MH  - *Affect
MH  - Behavioral Symptoms/diagnosis/psychology
MH  - *Bipolar Disorder/diagnosis/psychology
MH  - Child
MH  - *Cognition
MH  - Early Medical Intervention
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Needs Assessment
MH  - Neuropsychological Tests
MH  - *Social Adjustment
MH  - United States
PMC - PMC5517342
MID - NIHMS878254
OTO - NOTNLM
OT  - adolescents
OT  - bipolar disorder
OT  - children
OT  - cognitive functioning
OT  - longitudinal studies
COIS- Disclosure of Interests All other authors declare that they have no conflicts of 
      interest.
EDAT- 2017/06/28 06:00
MHDA- 2018/03/07 06:00
PMCR- 2018/06/27
CRDT- 2017/06/28 06:00
PHST- 2016/12/19 00:00 [received]
PHST- 2017/03/31 00:00 [revised]
PHST- 2017/05/09 00:00 [accepted]
PHST- 2017/06/28 06:00 [pubmed]
PHST- 2018/03/07 06:00 [medline]
PHST- 2017/06/28 06:00 [entrez]
PHST- 2018/06/27 00:00 [pmc-release]
AID - 10.1111/bdi.12510 [doi]
PST - ppublish
SO  - Bipolar Disord. 2017 Jun;19(4):273-284. doi: 10.1111/bdi.12510. Epub 2017 Jun 27.