PMID- 28654893
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20181113
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 29
DP  - 2017 Jul 18
TI  - Aberrant patterns of local and long-range functional connectivity densities in 
      schizophrenia.
PG  - 48196-48203
LID - 10.18632/oncotarget.18441 [doi]
AB  - Schizophrenia is a disorder of brain dysconnectivity, and both the connection 
      strength and connection number are disrupted in patients with schizophrenia. The 
      functional connectivity density (FCD) can reflect alterations in the connection 
      number. Alterations in the global FCD (gFCD) in schizophrenia were previously 
      demonstrated; however, alterations in two other indices of the pathological 
      characteristics of the brain, local FCD (lFCD) and long-range FCD (lrFCD), have 
      not been revealed. To investigate lFCD and lrFCD alterations in patients with 
      schizophrenia, 95 patients and 93 matched healthy controls were examined using 
      structural and resting-state functional magnetic resonance imaging scanning. lFCD 
      and lrFCD were measured using FCD mapping, and differences were identified using 
      a two-sample t-test in a voxel-wise manner, with age and gender considered to 
      increase variability. Multiple comparisons were performed using a false discovery 
      rate method with a corrected threshold of P<0.05. Our analysis showed that lFCD 
      was primarily decreased in the postcentral gyrus, right calcarine sulcus, and 
      inferior occipital gyrus lobule, but increased in the bilateral subcortical 
      regions. The differences in lFCD were more pronounced and complicated than those 
      in lrFCD. In summary, in contrast with previous studies that focused on the 
      connection strength, our findings, from the perspective of connection number, 
      indicate that schizophrenia is a disorder of brain dysconnectivity, particularly 
      affecting the local functional connectivity network, and support the hypothesis 
      that schizophrenia is associated with a widespread cortical functional 
      connectivity/activity deficit, with hyper- and/or hypo-connectivity/activity 
      coexisting in some cortical or subcortical regions.
FAU - Liu, Chuanxin
AU  - Liu C
AD  - Institute of Mental Health, Jining Medical University, Jining 272100, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wen Zhou 325000, 
      China.
FAU - Chen, Guangdong
AU  - Chen G
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wen Zhou 325000, 
      China.
FAU - Tian, Hongjun
AU  - Tian H
AD  - Department of Psychiatry, Tianjin Anding Hospital, Tianjin 300222, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Psychiatry, Tianjin Anding Hospital, Tianjin 300222, China.
FAU - Qu, Hongru
AU  - Qu H
AD  - Department of Psychiatry, Tianjin Anning Hospital, Tianjin 300300, China.
FAU - Cheng, Langlang
AU  - Cheng L
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wen Zhou 325000, 
      China.
FAU - Zhu, Jingjing
AU  - Zhu J
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wen Zhou 325000, 
      China.
FAU - Zhuo, Chuanjun
AU  - Zhuo C
AD  - Institute of Mental Health, Jining Medical University, Jining 272100, China.
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wen Zhou 325000, 
      China.
AD  - Department of Psychiatry, Tianjin Anding Hospital, Tianjin 300222, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
SB  - IM
MH  - Adult
MH  - Brain/physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Schizophrenia/*diagnosis/drug therapy
MH  - *Schizophrenic Psychology
MH  - Young Adult
PMC - PMC5564638
OTO - NOTNLM
OT  - functional connectivity density
OT  - magnetic resonance imaging
OT  - schizophrenia
COIS- CONFLICTS OF INTEREST There are no conflicts of interest.
EDAT- 2017/06/28 06:00
MHDA- 2018/04/24 06:00
PMCR- 2017/07/18
CRDT- 2017/06/28 06:00
PHST- 2017/01/28 00:00 [received]
PHST- 2017/05/06 00:00 [accepted]
PHST- 2017/06/28 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/06/28 06:00 [entrez]
PHST- 2017/07/18 00:00 [pmc-release]
AID - 18441 [pii]
AID - 10.18632/oncotarget.18441 [doi]
PST - ppublish
SO  - Oncotarget. 2017 Jul 18;8(29):48196-48203. doi: 10.18632/oncotarget.18441.