PMID- 28654895
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20220330
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 29
DP  - 2017 Jul 18
TI  - Preoperative albumin/globulin ratio has predictive value for patients with 
      laryngeal squamous cell carcinoma.
PG  - 48240-48247
LID - 10.18632/oncotarget.18443 [doi]
AB  - This study evaluated the predictive value of the preoperative albumin/globulin 
      ratio (AGR) in laryngeal squamous cell carcinoma (LSCC) retrospectively, which 
      has not been reported before. The current study enrolled 241 newly diagnosed LSCC 
      patients in the Second Affiliated Hospital of Nanchang University between January 
      2005 and December 2010. The optimal AGR cut-off value for overall survival (OS) 
      was determined to be 1.28. Univariate survival analysis identified sex, low AGR, 
      T classification, histological grade and nodal metastasis as factors associated 
      with poor OS. Additionally, a low AGR, T classification, nodal metastasis, and 
      histological grade were associated with poor disease-free survival (DFS) in LSCC 
      patients. In multivariate survival analysis, nodal metastasis and a low AGR 
      remained significant for OS and DFS. Our preliminary study revealed that low 
      preoperative AGR could serve as a valuable and easily-assessed blood-based 
      indicator to predict the prognosis of LSCC patients.
FAU - Chen, Wan-Zhi
AU  - Chen WZ
AD  - Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
FAU - Yu, Shi-Tong
AU  - Yu ST
AD  - Department of Otolaryngology, Head and Neck Surgery, Sun Yat-sen Memorial 
      Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
FAU - Xie, Rong
AU  - Xie R
AD  - Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
FAU - Lv, Yun-Xia
AU  - Lv YX
AD  - Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
FAU - Xu, De-Bin
AU  - Xu DB
AD  - Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
FAU - Yu, Ji-Chun
AU  - Yu JC
AD  - Department of Thyroid and Neck Surgery, The Second Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Serum Albumin)
RN  - 0 (Serum Globulins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor
MH  - Carcinoma, Squamous Cell/*blood/*mortality/pathology/surgery
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*blood/*mortality/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Preoperative Period
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - ROC Curve
MH  - *Serum Albumin
MH  - *Serum Globulins
PMC - PMC5564641
OTO - NOTNLM
OT  - albumin/globulin ratio
OT  - laryngeal squamous cell carcinoma
OT  - prognostic marker
COIS- CONFLICTS OF INTEREST These authors declare that they have no conflicts of 
      interest.
EDAT- 2017/06/28 06:00
MHDA- 2018/04/24 06:00
PMCR- 2017/07/18
CRDT- 2017/06/28 06:00
PHST- 2017/02/20 00:00 [received]
PHST- 2017/04/29 00:00 [accepted]
PHST- 2017/06/28 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/06/28 06:00 [entrez]
PHST- 2017/07/18 00:00 [pmc-release]
AID - 18443 [pii]
AID - 10.18632/oncotarget.18443 [doi]
PST - ppublish
SO  - Oncotarget. 2017 Jul 18;8(29):48240-48247. doi: 10.18632/oncotarget.18443.