PMID- 28656303 OWN - NLM STAT- MEDLINE DCOM- 20180205 LR - 20181202 IS - 1791-3004 (Electronic) IS - 1791-2997 (Linking) VI - 16 IP - 2 DP - 2017 Aug TI - Resveratrol reversed chronic restraint stress-induced impaired cognitive function in rats. PG - 2095-2100 LID - 10.3892/mmr.2017.6851 [doi] AB - Chronic stress occurs in everyday life, and often results in memory impairments and depressive symptoms. Resveratrol is a natural polyphenol that possesses numerous biological properties, including potent antidepressant‑like effects. The present study aimed to examine the effects of resveratrol treatment on chronic restraint stress (CRS)‑induced cognitive impairment and to explore the underlying molecular mechanisms. Male Wistar rats were exposed to CRS for 21 days in order to induce depressive‑like behavior. The results demonstrated that CRS (6 h/day, 21 days) was able to induce cognitive deficits in rats, as evidenced by Morris water maze and novel object recognition tests. In addition, CRS exposure significantly decreased the mRNA and protein expression levels of hippocampal brain‑derived neurotrophic factor (BDNF) in the rats. Conversely, chronic treatment with resveratrol (80 mg/kg, i.p.; 21 days) significantly prevented the behavioral and biochemical alterations induced by CRS. The effects of resveratrol were nearly identical to those observed with fluoxetine treatment. In conclusion, the present study demonstrated that resveratrol may be a potential therapeutic agent for the treatment of chronic stress‑induced cognitive impairments, and its underlying molecular mechanism may be associated with the increased levels of hippocampal BDNF. FAU - Zhang, Qian AU - Zhang Q AD - Department of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China. FAU - Wang, Xueer AU - Wang X AD - Department of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China. FAU - Bai, Xuemei AU - Bai X AD - Department of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China. FAU - Xie, Yunkai AU - Xie Y AD - Department of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China. FAU - Zhang, Tiantian AU - Zhang T AD - Department of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China. FAU - Bo, Shishi AU - Bo S AD - Department of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China. FAU - Chen, Xiaoyang AU - Chen X AD - Humanities Medical Research Center, Shandong University, Jinan, Shandong 250012, P.R. China. LA - eng PT - Journal Article DEP - 20170623 PL - Greece TA - Mol Med Rep JT - Molecular medicine reports JID - 101475259 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Stilbenes) RN - Q369O8926L (Resveratrol) SB - IM MH - Animals MH - Antidepressive Agents/pharmacology/*therapeutic use MH - Behavior, Animal/drug effects MH - Brain-Derived Neurotrophic Factor/analysis/genetics/metabolism MH - Cognition Disorders/*drug therapy/pathology MH - Disease Models, Animal MH - Enzyme-Linked Immunosorbent Assay MH - Hippocampus/metabolism MH - Male MH - Maze Learning/drug effects MH - Rats MH - Rats, Wistar MH - Resveratrol MH - Stilbenes/pharmacology/*therapeutic use MH - *Stress, Physiological EDAT- 2017/06/29 06:00 MHDA- 2018/02/06 06:00 CRDT- 2017/06/29 06:00 PHST- 2016/07/20 00:00 [received] PHST- 2017/05/02 00:00 [accepted] PHST- 2017/06/29 06:00 [pubmed] PHST- 2018/02/06 06:00 [medline] PHST- 2017/06/29 06:00 [entrez] AID - 10.3892/mmr.2017.6851 [doi] PST - ppublish SO - Mol Med Rep. 2017 Aug;16(2):2095-2100. doi: 10.3892/mmr.2017.6851. Epub 2017 Jun 23.