PMID- 28656632 OWN - NLM STAT- MEDLINE DCOM- 20191003 LR - 20191210 IS - 1365-2869 (Electronic) IS - 0962-1105 (Linking) VI - 27 IP - 1 DP - 2018 Feb TI - Serum brain-derived neurotrophic factor (BDNF) in sleep-disordered patients: relation to sleep stage N3 and rapid eye movement (REM) sleep across diagnostic entities. PG - 73-77 LID - 10.1111/jsr.12577 [doi] AB - Experimental and clinical evidence suggests an association between neuroplasticity, brain-derived neurotrophic factor and sleep. We aimed at testing the hypotheses that brain-derived neurotrophic factor is associated with specific aspects of sleep architecture or sleep stages in patients with sleep disorders. We included 35 patients with primary insomnia, 31 patients with restless legs syndrome, 17 patients with idiopathic hypersomnia, 10 patients with narcolepsy and 37 healthy controls. Morning serum brain-derived neurotrophic factor concentrations were measured in patients and controls. In patients, blood sampling was followed by polysomnographic sleep investigation. Low brain-derived neurotrophic factor levels were associated with a low percentage of sleep stage N3 and rapid eye movement sleep across diagnostic entities. However, there was no difference in brain-derived neurotrophic factor levels between diagnostic groups. Our data indicate that serum levels of brain-derived neurotrophic factor, independent of a specific sleep disorder, are related to the proportion of sleep stage N3 and REM sleep. This preliminary observation is in accordance with the assumption that sleep stage N3 is involved in the regulation of neuroplasticity. CI - (c) 2017 European Sleep Research Society. FAU - Deuschle, Michael AU - Deuschle M AUID- ORCID: 0000-0001-5038-1137 AD - Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. FAU - Schredl, Michael AU - Schredl M AD - Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. FAU - Wisch, Christian AU - Wisch C AD - Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. FAU - Schilling, Claudia AU - Schilling C AD - Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. FAU - Gilles, Maria AU - Gilles M AD - Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. FAU - Geisel, Olga AU - Geisel O AD - Department of Psychiatry and Psychotherapy, Charite, Berlin, Germany. FAU - Hellweg, Rainer AU - Hellweg R AD - Department of Psychiatry and Psychotherapy, Charite, Berlin, Germany. LA - eng PT - Clinical Trial PT - Journal Article DEP - 20170628 PL - England TA - J Sleep Res JT - Journal of sleep research JID - 9214441 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Female MH - Humans MH - Idiopathic Hypersomnia/*blood/diagnosis MH - Male MH - Middle Aged MH - Narcolepsy/*blood/diagnosis MH - Polysomnography/methods MH - Restless Legs Syndrome/*blood/diagnosis MH - Sleep Initiation and Maintenance Disorders/*blood/diagnosis MH - Sleep Stages/physiology MH - Sleep, REM/*physiology MH - Sleep, Slow-Wave/*physiology OTO - NOTNLM OT - neuroplasticity OT - neurotrophic factors OT - synaptic homeostasis theory EDAT- 2017/06/29 06:00 MHDA- 2019/10/08 06:00 CRDT- 2017/06/29 06:00 PHST- 2017/05/18 00:00 [accepted] PHST- 2017/02/14 00:00 [received] PHST- 2017/06/29 06:00 [pubmed] PHST- 2019/10/08 06:00 [medline] PHST- 2017/06/29 06:00 [entrez] AID - 10.1111/jsr.12577 [doi] PST - ppublish SO - J Sleep Res. 2018 Feb;27(1):73-77. doi: 10.1111/jsr.12577. Epub 2017 Jun 28.