PMID- 28656685
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20181202
IS  - 1526-9914 (Electronic)
IS  - 1526-9914 (Linking)
VI  - 18
IP  - 5
DP  - 2017 Sep
TI  - Impacts of lung and tumor volumes on lung dosimetry for nonsmall cell lung 
      cancer.
PG  - 22-28
LID - 10.1002/acm2.12104 [doi]
AB  - The purpose of this study was to determine the impacts of lung and tumor volumes 
      on normal lung dosimetry in three-dimensional conformal radiotherapy (3DCRT), 
      step-and-shoot intensity-modulated radiotherapy (ssIMRT), and single full-arc 
      volumetric-modulated arc therapy (VMAT) in treatment of nonsmall cell lung 
      cancers (NSCLC). All plans were designed to deliver a total dose of 66 Gy in 33 
      fractions to PTV for the 32 NSCLC patients with various total (bilateral) lung 
      volumes, planning target volumes (PTVs), and PTV locations. The ratio of the lung 
      volume (total lung volume excluding the PTV volume) to the PTV volume (LTR) was 
      evaluated to represent the impacts in three steps. (a) The least squares method 
      was used to fit mean lung doses (MLDs) to PTVs or LTRs with power-law function in 
      the population cohort (N = 32). (b) The population cohort was divided into three 
      groups by LTRs based on first step and then by PTVs, respectively. The MLDs were 
      compared among the three techniques in each LTR group (LG) and each PTV group 
      (PG). (c) The power-law correlation was tested by using the adaptive radiation 
      therapy (ART) planning data of individual patients in the individual cohort (N = 
      4). Different curves of power-law function with high R(2) values were observed 
      between averaged LTRs and averaged MLDs for 3DCRT, ssIMRT, and VMAT, 
      respectively. In the individual cohort, high R(2) values of fitting curves were 
      also observed in individual patients in ART, although the trend was highly 
      patient-specific. There was a more obvious correlation between LTR and MLD than 
      that between PTV and MLD.
CI  - (c) 2017 The Authors. Journal of Applied Clinical Medical Physics published by 
      Wiley Periodicals, Inc. on behalf of American Association of Physicists in 
      Medicine.
FAU - Lei, Weijie
AU  - Lei W
AD  - University of Science and Technology of China, Hefei, China.
AD  - Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy 
      Safety Technology, Chinese Academy of Sciences, Hefei, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy of Anhui 
      Province, Hefei, China.
AD  - The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
FAU - Jia, Jing
AU  - Jia J
AD  - Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy 
      Safety Technology, Chinese Academy of Sciences, Hefei, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy of Anhui 
      Province, Hefei, China.
FAU - Cao, Ruifen
AU  - Cao R
AD  - Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy 
      Safety Technology, Chinese Academy of Sciences, Hefei, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy of Anhui 
      Province, Hefei, China.
FAU - Song, Jing
AU  - Song J
AD  - Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy 
      Safety Technology, Chinese Academy of Sciences, Hefei, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy of Anhui 
      Province, Hefei, China.
FAU - Hu, Liqin
AU  - Hu L
AD  - University of Science and Technology of China, Hefei, China.
AD  - Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy 
      Safety Technology, Chinese Academy of Sciences, Hefei, China.
AD  - Engineering Technology Research Center of Accurate Radiotherapy of Anhui 
      Province, Hefei, China.
LA  - eng
PT  - Journal Article
DEP - 20170628
PL  - United States
TA  - J Appl Clin Med Phys
JT  - Journal of applied clinical medical physics
JID - 101089176
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*pathology/*radiotherapy
MH  - Humans
MH  - Lung/*pathology
MH  - Lung Neoplasms/*pathology/*radiotherapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Intensity-Modulated
MH  - *Tumor Burden
PMC - PMC5874952
OTO - NOTNLM
OT  - intensity-modulated radiotherapy
OT  - lung cancer
OT  - volumetric-modulated arc therapy
EDAT- 2017/06/29 06:00
MHDA- 2018/04/03 06:00
PMCR- 2017/06/28
CRDT- 2017/06/29 06:00
PHST- 2016/11/23 00:00 [received]
PHST- 2017/03/29 00:00 [revised]
PHST- 2017/04/05 00:00 [accepted]
PHST- 2017/06/29 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
PHST- 2017/06/29 06:00 [entrez]
PHST- 2017/06/28 00:00 [pmc-release]
AID - ACM212104 [pii]
AID - 10.1002/acm2.12104 [doi]
PST - ppublish
SO  - J Appl Clin Med Phys. 2017 Sep;18(5):22-28. doi: 10.1002/acm2.12104. Epub 2017 
      Jun 28.