PMID- 28656803
OWN - NLM
STAT- MEDLINE
DCOM- 20181017
LR  - 20181017
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 19
IP  - 5
DP  - 2018 Aug
TI  - Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in 
      major depression.
PG  - 402-409
LID - 10.1080/15622975.2017.1347713 [doi]
AB  - OBJECTIVES: Current evidence supports participation of neurotrophic and 
      inflammatory factors in the pathogenesis of major depressive disorder (MDD). Some 
      studies reported an association between the Val66Met polymorphism (rs6265) of 
      brain-derived neurotrophic factor (BDNF) gene with MDD and peripheral BDNF 
      levels. However, no previous studies have examined the association of this 
      polymorphism with inflammation. The present study assessed the association of the 
      Val66Met polymorphism with serum levels of BDNF and inflammatory markers among 
      depressed outpatients. METHODS: All participants (n = 73) met DSM-IV criteria for 
      a unipolar depressive episode. The serum levels of BDNF and inflammatory 
      biomarkers (IL-2, IL-4, IL-6, IL-10, TNF-alpha and IFN-gamma) were compared between 
      individuals presenting with at least one Met allele (Met-carriers) and those 
      homozygous for the Val allele. RESULTS: In our sample (84.9% female, mean age 
      52.4 +/- 10.3 years), 24.7% (n = 18) were Met-carriers. After Bonferroni 
      correction, the Met allele was significantly associated with higher BDNF and 
      lower TNF-alpha. These associations persisted after adjusting for potential 
      confounders. CONCLUSIONS: The pattern of low BDNF and high inflammation in MDD 
      may be influenced by the Val66Met polymorphism. The association of a polymorphism 
      in the BDNF gene with inflammatory markers in addition to BDNF levels suggests an 
      interaction between these systems.
FAU - Caldieraro, Marco Antonio
AU  - Caldieraro MA
AD  - a Department of Psychiatry , Massachusetts General Hospital , Boston , MA , USA.
AD  - b Department of Psychiatry , Hospital de Clinicas de Porto Alegre , Porto Alegre 
      , Brasil.
FAU - McKee, Madison
AU  - McKee M
AD  - c Depression Clinical and Research Program , Massachusetts General Hospital , 
      Boston , MA , USA.
FAU - Leistner-Segal, Sandra
AU  - Leistner-Segal S
AD  - d Medical Genetics Service, Molecular Genetics Laboratory , Hospital de Clinicas 
      de Porto Alegre , Porto Alegre , Brasil.
AD  - e Experimental Research Center , B.R.A.I.N. Laboratory, Hospital de Clinicas de 
      Porto Alegre , Porto Alegre , Brasil.
FAU - Vares, Edgar Arrua
AU  - Vares EA
AD  - f Programa de Pos-Graduacao Ciencias Medicas: Psiquiatria, Department of 
      Psychiatry and Forensic Medicine , Universidade Federal do Rio Grande do Sul 
      (UFRGS) , Porto Alegre , Brasil.
FAU - Kubaski, Francyne
AU  - Kubaski F
AD  - g Department of Research , Nemours/Alfred I. duPont Hospital for Children , 
      Wilmington , DE , USA.
AD  - h Department of Biological Sciences , University of Delaware , Newark , DE , USA.
AD  - i Department of Research , Instituto Nacional de Genetica Medica 
      Populacional-INAGEMP , Porto Alegre , Brasil.
FAU - Spanemberg, Lucas
AU  - Spanemberg L
AD  - f Programa de Pos-Graduacao Ciencias Medicas: Psiquiatria, Department of 
      Psychiatry and Forensic Medicine , Universidade Federal do Rio Grande do Sul 
      (UFRGS) , Porto Alegre , Brasil.
AD  - j Department of Psychiatry , Nucleo de Formacao Especifica em Psiquiatria da 
      Escola de Medicina da Pontificia Universidade Catolica do Rio Grande do Sul, 
      Porto Alegre , Brasil.
FAU - Brusius-Facchin, Ana Carolina
AU  - Brusius-Facchin AC
AD  - d Medical Genetics Service, Molecular Genetics Laboratory , Hospital de Clinicas 
      de Porto Alegre , Porto Alegre , Brasil.
FAU - Fleck, Marcelo P
AU  - Fleck MP
AD  - b Department of Psychiatry , Hospital de Clinicas de Porto Alegre , Porto Alegre 
      , Brasil.
AD  - f Programa de Pos-Graduacao Ciencias Medicas: Psiquiatria, Department of 
      Psychiatry and Forensic Medicine , Universidade Federal do Rio Grande do Sul 
      (UFRGS) , Porto Alegre , Brasil.
FAU - Mischoulon, David
AU  - Mischoulon D
AD  - c Depression Clinical and Research Program , Massachusetts General Hospital , 
      Boston , MA , USA.
AD  - k Department of Psychiatry , Harvard Medical School , Boston , MA , USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170712
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - *Depressive Disorder, Major/blood/genetics/immunology
MH  - Female
MH  - Humans
MH  - Inflammation/*blood
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*blood
OTO - NOTNLM
OT  - Depression
OT  - brain-derived neurotrophic factor
OT  - genetics
OT  - inflammation
OT  - tumour necrosis factor-alpha
EDAT- 2017/06/29 06:00
MHDA- 2018/10/18 06:00
CRDT- 2017/06/29 06:00
PHST- 2017/06/29 06:00 [pubmed]
PHST- 2018/10/18 06:00 [medline]
PHST- 2017/06/29 06:00 [entrez]
AID - 10.1080/15622975.2017.1347713 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2018 Aug;19(5):402-409. doi: 
      10.1080/15622975.2017.1347713. Epub 2017 Jul 12.