PMID- 28656817
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20180827
IS  - 1758-1001 (Electronic)
IS  - 0004-5632 (Linking)
VI  - 55
IP  - 2
DP  - 2018 Mar
TI  - High sensitivity troponin T and I reflect left atrial function being assessed by 
      cardiac magnetic resonance imaging.
PG  - 264-275
LID - 10.1177/0004563217714004 [doi]
AB  - Background Left atrial function (LAF) plays an interactive role between pulmonary 
      and systemic circulation. Cardiac biomarkers, such as amino-terminal pro-brain 
      natriuretic peptide (NT-proBNP) and troponins, might reflect cardiac function. 
      This study aims to evaluate the association between high sensitivity troponins 
      (hsTn) and left atrial function in patients undergoing cardiac magnetic resonance 
      imaging (cMRI). Methods Patients undergoing cardiac magnetic resonance imaging 
      (cMRI) were enrolled prospectively. Patients with right ventricular dysfunction 
      (<50%) were excluded. Blood samples for measurements of hsTn and NT-proBNP were 
      collected at the time of cMRI. Results Eighty-four patients were included. Median 
      LVEF was 59% (IQR 51-64%). HsTn correlated inversely with LAF within 
      multivariable linear regression models (hsTnI: Beta -0.46; T -4.44; P = 0.0001; 
      hsTnT: Beta -0.29; T -3.06; P = 0.003). High sensitivity troponins increased 
      significantly according to decreasing stages of impaired LAF ( P = 0.0001). High 
      sensitivity troponins discriminated patients with impaired LAF < 55% (hsTnT: 
      AUC = 0.80; P = 0.0001; hsTnI: AUC = 0.74; P = 0.0001) and <45% (hsTnT: 
      AUC = 0.75; P = 0.0001; hsTnI: AUC = 0.73; P = 0.001) and were still 
      significantly associated in multivariable logistic regression models (LAF < 55%: 
      hsTnT: OR = 21.78; P = 0.0001; hsTnI: OR = 5.96; P = 0.009; LAF < 45%: hsTnT: 
      OR = 10.27; P = 0.0001; hsTnI: OR = 12.56; P = 0.001). Conclusions This study 
      demonstrates that hsTn are able to reflect LAF being assessed by cardiac magnetic 
      resonance imaging.
FAU - Natale, Michele
AU  - Natale M
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Behnes, Michael
AU  - Behnes M
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Kim, Seung-Hyun
AU  - Kim SH
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Hoffmann, Julia
AU  - Hoffmann J
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Reckord, Nadine
AU  - Reckord N
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Hoffmann, Ursula
AU  - Hoffmann U
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Budjan, Johannes
AU  - Budjan J
AD  - 2 Institute of Clinical Radiology and Nuclear Medicine, University Medical Center 
      Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, 
      Germany.
FAU - Lang, Siegfried
AU  - Lang S
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Borggrefe, Martin
AU  - Borggrefe M
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Papavassiliu, Theano
AU  - Papavassiliu T
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Bertsch, Thomas
AU  - Bertsch T
AD  - 3 Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, 
      General Hospital Nuremberg, Paracelsus Medical University, Nuremberg, Germany.
FAU - Akin, Ibrahim
AU  - Akin I
AD  - 1 First Department of Medicine, University Medical Center Mannheim (UMM), Faculty 
      of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
LA  - eng
PT  - Journal Article
DEP - 20171127
PL  - England
TA  - Ann Clin Biochem
JT  - Annals of clinical biochemistry
JID - 0324055
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Troponin I)
RN  - 0 (Troponin T)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Function, Left
MH  - Biomarkers/blood
MH  - Female
MH  - Heart Atria/*diagnostic imaging/physiopathology
MH  - Heart Diseases/physiopathology
MH  - Humans
MH  - Limit of Detection
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Prospective Studies
MH  - Troponin I/*blood
MH  - Troponin T/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - NT-proBNP
OT  - high sensitivity troponin
OT  - left atrium
OT  - troponin I
OT  - troponin T
EDAT- 2017/06/29 06:00
MHDA- 2018/08/28 06:00
CRDT- 2017/06/29 06:00
PHST- 2017/06/29 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2017/06/29 06:00 [entrez]
AID - 10.1177/0004563217714004 [doi]
PST - ppublish
SO  - Ann Clin Biochem. 2018 Mar;55(2):264-275. doi: 10.1177/0004563217714004. Epub 
      2017 Nov 27.