PMID- 28656967
OWN - NLM
STAT- MEDLINE
DCOM- 20180801
LR  - 20180802
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 71
IP  - 12
DP  - 2017 Dec
TI  - Low appendicular muscle mass is associated with mortality in peritoneal dialysis 
      patients: a single-center cohort study.
PG  - 1405-1410
LID - 10.1038/ejcn.2017.104 [doi]
AB  - BACKGROUND/OBJECTIVES: There are few studies of the association between low 
      appendicular muscle mass (LAM) and clinical outcomes in peritoneal dialysis (PD) 
      patients. We aimed to determine the clinical association between LAM and clinical 
      outcomes in PD patients. SUBJECT/METHODS: We reviewed all PD patients who 
      underwent PD between January 2001 and April 2014. Each patient's appendicular 
      lean mass was estimated using dual-energy X-ray absorptiometry. The appendicular 
      muscle mass index (AMI) was calculated using total appendicular lean mass (kg) 
      over body mass index (kg/m(2)). The cut-off AMI value for LAM was <0.789 for men 
      and <0.512 for women. RESULTS: The number of patients in the Non-LAM and LAM 
      groups was 328 and 303, respectively. The median follow-up durations in the 
      Non-LAM and LAM groups were 47 and 49 months, respectively. The numbers of deaths 
      in the Non-LAM and LAM groups were 96 (29.3%) and 160 (52.8%), respectively. In a 
      comparison with the Non-LAM group, the hazard ratio in the LAM group was 1.74 
      (95% confidence interval (CI), 1.35-2.24) in univariate and 1.71 (95% CI, 
      1.28-2.26) in multivariate Cox regression analysis. In addition, the hazard ratio 
      for a 0.1 increase in baseline AMI was 0.89 (95% CI, 0.84-0.95) in univariate 
      analysis and 0.84 (95% CI, 0.76-0.91) in multivariate analysis. Analyses using 
      the 1-year AMI showed trends similar to those for the initial AMI. CONCLUSIONS: 
      Our study showed the association of LAM with mortality in the incident PD 
      patients.
FAU - Kang, S H
AU  - Kang SH
AD  - Division of Nephrology, Department of Internal Medicine, Yeungnam University 
      Hospital, Daegu, Korea.
FAU - Cho, K H
AU  - Cho KH
AD  - Division of Nephrology, Department of Internal Medicine, Yeungnam University 
      Hospital, Daegu, Korea.
FAU - Park, J W
AU  - Park JW
AD  - Division of Nephrology, Department of Internal Medicine, Yeungnam University 
      Hospital, Daegu, Korea.
FAU - Do, J Y
AU  - Do JY
AD  - Division of Nephrology, Department of Internal Medicine, Yeungnam University 
      Hospital, Daegu, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170628
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Serum Albumin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adult
MH  - Aged
MH  - Body Composition
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*physiopathology
MH  - Peritoneal Dialysis/adverse effects/*mortality
MH  - Prevalence
MH  - Proportional Hazards Models
MH  - Renal Insufficiency, Chronic/*mortality/therapy
MH  - Risk Factors
MH  - Serum Albumin/metabolism
EDAT- 2017/06/29 06:00
MHDA- 2018/08/02 06:00
CRDT- 2017/06/29 06:00
PHST- 2016/07/15 00:00 [received]
PHST- 2017/05/03 00:00 [revised]
PHST- 2017/05/10 00:00 [accepted]
PHST- 2017/06/29 06:00 [pubmed]
PHST- 2018/08/02 06:00 [medline]
PHST- 2017/06/29 06:00 [entrez]
AID - ejcn2017104 [pii]
AID - 10.1038/ejcn.2017.104 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2017 Dec;71(12):1405-1410. doi: 10.1038/ejcn.2017.104. Epub 2017 
      Jun 28.