PMID- 2865726
OWN - NLM
STAT- MEDLINE
DCOM- 19851203
LR  - 20160725
IS  - 0375-9660 (Print)
IS  - 0375-9660 (Linking)
VI  - 31
IP  - 3
DP  - 1985 May-Jun
TI  - [Role of histamine as an intermediary in the action of estradiol on the rat 
      uterus: inhibition of the hormonal induction of enzymes using histamine 
      antagonists].
PG  - 73-8
AB  - The administration of methiamide, a blocker of histamine H2-receptors, to rats 
      was shown to prevent the induction of hexokinase (HK) and glucose-6-phosphate 
      dehydrogenase (G-6PD) caused by both histamine and estradiol. An inhibitory 
      effect of methiamide remained stable up to 16 h after histamine and estradiol 
      administration. Diphenhydramine, a blocker of histamine H1-receptors, produces a 
      short-term inhibitory effect on the HK and G-6PD activity stimulated by histamine 
      and estradiol. The short-term nature of the diphenhydramine effect may be 
      attributed to a low affinity to histamine H2-receptors and histamine fast 
      dissociation. It may be concluded that some of the estradiol effects, 
      particularly the HK and G-6PD induction in the uterus are histamine-mediated, 
      apparently by means of H2-receptors. The administration of histamine to rats 
      increases the uterus mass causing its inundation, and H1- and H2-blockers prevent 
      this effect of histamine. However, the above histamine antagonists do not inhibit 
      uterus inundation caused by estradiol. A conclusion is made that estradiol 
      stimulates the uterus inundation not only by means of histamine but also by some 
      other means.
FAU - Pankova, T G
AU  - Pankova TG
FAU - Igonina, T M
AU  - Igonina TM
FAU - Salganik, R I
AU  - Salganik RI
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Rol' gistamina kak posrednika v deistvii estradiola ma matku krys: tormozhenie 
      gormonal'noi induktsii fermentov s pomoshch'iu antagonistov histamina.
PL  - Russia (Federation)
TA  - Probl Endokrinol (Mosk)
JT  - Problemy endokrinologii
JID - 0140673
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Histamine H2 Antagonists)
RN  - 3K7670861M (Metiamide)
RN  - 4TI98Z838E (Estradiol)
RN  - 820484N8I3 (Histamine)
RN  - 8GTS82S83M (Diphenhydramine)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - Diphenhydramine/pharmacology
MH  - Enzyme Induction
MH  - Estradiol/*physiology
MH  - Female
MH  - Glucosephosphate Dehydrogenase/*biosynthesis
MH  - Hexokinase/*biosynthesis
MH  - Histamine/*physiology
MH  - Histamine H1 Antagonists/pharmacology
MH  - Histamine H2 Antagonists/pharmacology
MH  - Metiamide/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Uterus/drug effects/*enzymology
EDAT- 1985/05/01 00:00
MHDA- 1985/05/01 00:01
CRDT- 1985/05/01 00:00
PHST- 1985/05/01 00:00 [pubmed]
PHST- 1985/05/01 00:01 [medline]
PHST- 1985/05/01 00:00 [entrez]
PST - ppublish
SO  - Probl Endokrinol (Mosk). 1985 May-Jun;31(3):73-8.